lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	26524
Symbol	LATS2
Synonymous	KPM
Full name	large tumor suppressor kinase 2
Gene description	LATS (large tumor suppressor, Drosophila) homolog 2\|LATS, large tumor suppressor, homolog 2\|kinase phosphorylated during mitosis protein\|large tumor suppressor homolog 2\|serine/threonine kinase KPM\|serine/threonine-protein kinase LATS2\|serine/threonine-pr
Cytoband	13q12.11
Gene type	protein-coding
Synonymous	MIM:604861; HGNC:HGNC:6515; Ensembl:ENSG00000150457; HPRD:07277; Vega:OTTHUMG00000016531

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.166G>T; p.D56Y; 13:21045861-21045861	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.949C>T; p.H317Y; 13:20988831-20988831	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3160C>T; p.R1054*; 13:20974977-20974977	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1437G>C; p.P479P; 13:20988343-20988343	thyroid	other; neoplasm	Substitution - coding silent
c.2642C>T; p.A881V; 13:20981489-20981489	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2993A>G; p.D998G; 13:20975144-20975144	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1800C>T; p.Y600Y; 13:20987980-20987980	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.486C>T; p.L162L; 13:20989294-20989294	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.341A>G; p.Q114R; 13:21045686-21045686	liver	carcinoma	Substitution - Missense
c.341A>G; p.Q114R; 13:21045686-21045686	liver	carcinoma	Substitution - Missense
c.2521C>T; p.L841F; 13:20981610-20981610	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1436_1437insGGGGCG; p.P479_A480insGR; 13:20988343-20988344	pancreas	carcinoid-endocrine_tumour; islet_cell	Insertion - In frame
c.1637C>T; p.A546V; 13:20988143-20988143	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2028C>T; p.I676I; 13:20983678-20983678	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.821C>T; p.S274F; 13:20988959-20988959	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.573C>T; p.Y191Y; 13:20989207-20989207	central_nervous_system; brain	glioma	Substitution - coding silent
c.2707C>A; p.L903I; 13:20979756-20979756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1241C>T; p.P414L; 13:20988539-20988539	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.978C>T; p.H326H; 13:20988802-20988802	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1098C>T; p.S366S; 13:20988682-20988682	skin	malignant_melanoma	Substitution - coding silent
c.623C>T; p.P208L; 13:20989157-20989157	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.272C>T; p.S91L; 13:21045755-21045755	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.741G>T; p.P247P; 13:20989039-20989039	pancreas	carcinoma	Substitution - coding silent
c.272C>T; p.S91L; 13:21045755-21045755	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2882G>A; p.R961Q; 13:20975255-20975255	liver	carcinoma	Substitution - Missense
c.1548G>A; p.P516P; 13:20988232-20988232	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.98C>T; p.S33L; 13:21045929-21045929	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2308T>C; p.F770L; 13:20983398-20983398	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1361C>T; p.P454L; 13:20988419-20988419	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2407G>T; p.G803C; 13:20983299-20983299	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2562G>A; p.L854L; 13:20981569-20981569	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3045C>T; p.S1015S; 13:20975092-20975092	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3045C>T; p.S1015S; 13:20975092-20975092	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3045C>T; p.S1015S; 13:20975092-20975092	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3045C>T; p.S1015S; 13:20975092-20975092	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.228C>T; p.A76A; 13:21045799-21045799	liver	carcinoma	Substitution - coding silent
c.228C>T; p.A76A; 13:21045799-21045799	liver	carcinoma	Substitution - coding silent
c.3261C>T; p.Y1087Y; 13:20974876-20974876	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2792C>T; p.T931M; 13:20975345-20975345	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1673G>A; p.R558H; 13:20988107-20988107	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2164G>T; p.E722*; 13:20983542-20983542	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1615G>C; p.G539R; 13:20988165-20988165	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2741delT; p.L914fs*10; 13:20979722-20979722	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1954G>T; p.E652*; 13:20983752-20983752	breast	carcinoma	Substitution - Nonsense
c.648C>T; p.F216F; 13:20989132-20989132	skin	malignant_melanoma	Substitution - coding silent
c.2449A>G; p.R817G; 13:20983257-20983257	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1164G>A; p.A388A; 13:20988616-20988616	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.648C>T; p.F216F; 13:20989132-20989132	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.431C>T; p.P144L; 13:20991316-20991316	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2466C>T; p.S822S; 13:20983240-20983240	skin	malignant_melanoma	Substitution - coding silent
c.2705T>A; p.I902N; 13:20979758-20979758	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3257T>C; p.V1086A; 13:20974880-20974880	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2705T>A; p.I902N; 13:20979758-20979758	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3257T>C; p.V1086A; 13:20974880-20974880	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2206C>T; p.Q736*; 13:20983500-20983500	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2583G>A; p.A861A; 13:20981548-20981548	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3115G>A; p.E1039K; 13:20975022-20975022	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3144C>T; p.D1048D; 13:20974993-20974993	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.3232G>T; p.D1078Y; 13:20974905-20974905	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2475C>T; p.Y825Y; 13:20983231-20983231	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.536C>T; p.S179L; 13:20989244-20989244	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.536C>T; p.S179L; 13:20989244-20989244	breast	carcinoma	Substitution - Missense
c.653G>T; p.G218V; 13:20989127-20989127	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1179C>T; p.H393H; 13:20988601-20988601	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1179C>T; p.H393H; 13:20988601-20988601	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.589G>A; p.G197S; 13:20989191-20989191	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.64A>G; p.I22V; 13:21045963-21045963	liver	carcinoma	Substitution - Missense
c.2316C>G; p.I772M; 13:20983390-20983390	ovary	other; neoplasm	Substitution - Missense
c.64A>G; p.I22V; 13:21045963-21045963	liver	carcinoma	Substitution - Missense
c.3084C>A; p.P1028P; 13:20975053-20975053	skin	malignant_melanoma	Substitution - coding silent
c.1706A>G; p.D569G; 13:20988074-20988074	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2145C>T; p.A715A; 13:20983561-20983561	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2688G>A; p.W896*; 13:20979775-20979775	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.1638_1639GG>AA; p.G547S; 13:20988141-20988142	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.991C>A; p.L331M; 13:20988789-20988789	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1846A>G; p.T616A; 13:20987934-20987934	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2712C>T; p.F904F; 13:20979751-20979751	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1920G>T; p.E640D; 13:20983786-20983786	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3121A>C; p.T1041P; 13:20975016-20975016	breast	carcinoma	Substitution - Missense
c.2512C>T; p.P838S; 13:20981619-20981619	skin	malignant_melanoma	Substitution - Missense
c.496C>T; p.P166S; 13:20989284-20989284	skin	malignant_melanoma	Substitution - Missense
c.2512C>T; p.P838S; 13:20981619-20981619	skin	malignant_melanoma	Substitution - Missense
c.1174G>A; p.A392T; 13:20988606-20988606	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2964delC; p.Y989fs*17; 13:20975173-20975173	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.238delA; p.I80fs*20; 13:21045789-21045789	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1994A>G; p.K665R; 13:20983712-20983712	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.67C>T; p.R23C; 13:21045960-21045960	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2441C>G; p.T814S; 13:20983265-20983265	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2077C>A; p.L693M; 13:20983629-20983629	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3155_3156CC>TT; p.P1052L; 13:20974981-20974982	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3048A>G; p.E1016E; 13:20975089-20975089	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3048A>G; p.E1016E; 13:20975089-20975089	large_intestine; rectum	NS	Substitution - coding silent
c.328G>A; p.A110T; 13:21045699-21045699	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3200A>C; p.E1067A; 13:20974937-20974937	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1176_1177delGC; p.H393fs*6; 13:20988603-20988604	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1872G>A; p.R624R; 13:20987908-20987908	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2659C>T; p.R887C; 13:20981472-20981472	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2044G>T; p.V682L; 13:20983662-20983662	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2317G>A; p.A773T; 13:20983389-20983389	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2023G>T; p.G675W; 13:20983683-20983683	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1681G>A; p.A561T; 13:20988099-20988099	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1673G>T; p.R558L; 13:20988107-20988107	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1681G>A; p.A561T; 13:20988099-20988099	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2934C>A; p.F978L; 13:20975203-20975203	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.52C>T; p.R18*; 13:21045975-21045975	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1340T>A; p.V447E; 13:20988440-20988440	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2478G>C; p.Q826H; 13:20983228-20983228	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2552G>A; p.G851E; 13:20981579-20981579	skin	malignant_melanoma	Substitution - Missense
c.1674C>T; p.R558R; 13:20988106-20988106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2429T>C; p.F810S; 13:20983277-20983277	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2295G>T; p.E765D; 13:20983411-20983411	large_intestine; colon	carcinoma	Substitution - Missense
c.1493G>T; p.G498V; 13:20988287-20988287	central_nervous_system; brain	glioma	Substitution - Missense
c.2324T>C; p.L775P; 13:20983382-20983382	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1172G>A; p.R391H; 13:20988608-20988608	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.327C>T; p.N109N; 13:21045700-21045700	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.503C>T; p.T168M; 13:20989277-20989277	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.503C>T; p.T168M; 13:20989277-20989277	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3122C>T; p.T1041I; 13:20975015-20975015	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.432G>A; p.P144P; 13:20991315-20991315	pancreas	carcinoma	Substitution - coding silent
c.3122C>T; p.T1041I; 13:20975015-20975015	large_intestine; colon	carcinoma	Substitution - Missense
c.503C>T; p.T168M; 13:20989277-20989277	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2640C>T; p.I880I; 13:20981491-20981491	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3122C>T; p.T1041I; 13:20975015-20975015	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.119G>A; p.G40E; 13:21045908-21045908	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.119G>A; p.G40E; 13:21045908-21045908	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2554G>A; p.D852N; 13:20981577-20981577	breast	carcinoma	Substitution - Missense
c.2003_2006delTTGT; p.F668fs*28; 13:20983700-20983703	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.548A>G; p.Y183C; 13:20989232-20989232	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1489G>A; p.A497T; 13:20988291-20988291	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2073C>T; p.H691H; 13:20983633-20983633	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1927C>G; p.Q643E; 13:20983779-20983779	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1997C>T; p.S666F; 13:20983709-20983709	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1730C>T; p.P577L; 13:20988050-20988050	skin	malignant_melanoma	Substitution - Missense
c.1557G>A; p.P519P; 13:20988223-20988223	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.574G>A; p.E192K; 13:20989206-20989206	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3036C>T; p.N1012N; 13:20975101-20975101	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3036C>T; p.N1012N; 13:20975101-20975101	central_nervous_system; brain	glioma	Substitution - coding silent
c.1143G>T; p.L381L; 13:20988637-20988637	thyroid	carcinoma	Substitution - coding silent
c.2113C>T; p.L705L; 13:20983593-20983593	skin	malignant_melanoma	Substitution - coding silent
c.47G>T; p.R16L; 13:21045980-21045980	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1424C>T; p.P475L; 13:20988356-20988356	skin	malignant_melanoma	Substitution - Missense
c.1777C>T; p.R593C; 13:20988003-20988003	central_nervous_system; brain	glioma	Substitution - Missense
c.532G>A; p.D178N; 13:20989248-20989248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.751G>A; p.A251T; 13:20989029-20989029	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2908C>A; p.H970N; 13:20975229-20975229	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1479G>A; p.A493A; 13:20988301-20988301	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1741C>T; p.R581C; 13:20988039-20988039	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.569C>G; p.P190R; 13:20989211-20989211	breast	carcinoma	Substitution - Missense
c.2888G>A; p.G963E; 13:20975249-20975249	liver	carcinoma	Substitution - Missense
c.2888G>A; p.G963E; 13:20975249-20975249	liver	carcinoma	Substitution - Missense
c.1659C>T; p.G553G; 13:20988121-20988121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1659C>T; p.G553G; 13:20988121-20988121	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1659C>T; p.G553G; 13:20988121-20988121	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.597C>T; p.D199D; 13:20989183-20989183	oesophagus	carcinoma	Substitution - coding silent
c.2899C>A; p.L967M; 13:20975238-20975238	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3046G>A; p.E1016K; 13:20975091-20975091	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1283C>T; p.A428V; 13:20988497-20988497	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3046G>A; p.E1016K; 13:20975091-20975091	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.3248G>A; p.C1083Y; 13:20974889-20974889	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>A; p.G177G; 13:20989249-20989249	breast	carcinoma	Substitution - coding silent
c.2725G>A; p.G909R; 13:20979738-20979738	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2398G>T; p.D800Y; 13:20983308-20983308	breast	carcinoma	Substitution - Missense
c.359C>G; p.A120G; 13:20991388-20991388	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2987C>T; p.P996L; 13:20975150-20975150	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1759G>A; p.E587K; 13:20988021-20988021	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2679C>A; p.L893L; 13:20979784-20979784	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.314A>C; p.Q105P; 13:21045713-21045713	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3161G>A; p.R1054Q; 13:20974976-20974976	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2964C>A; p.P988P; 13:20975173-20975173	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.628C>T; p.P210S; 13:20989152-20989152	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2775G>A; p.V925V; 13:20975362-20975362	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.2775G>A; p.V925V; 13:20975362-20975362	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1583C>T; p.S528L; 13:20988197-20988197	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2114T>C; p.L705P; 13:20983592-20983592	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3128G>T; p.R1043L; 13:20975009-20975009	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	breast	carcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	thyroid	other; neoplasm	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 13:20988809-20988809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2030G>T; p.G677V; 13:20983676-20983676	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2858G>T; p.C953F; 13:20975279-20975279	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2018C>T; p.T673I; 13:20983688-20983688	skin	malignant_melanoma	Substitution - Missense
c.2176G>A; p.E726K; 13:20983530-20983530	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2922C>T; p.S974S; 13:20975215-20975215	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.215C>T; p.P72L; 13:21045812-21045812	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1033C>T; p.Q345*; 13:20988747-20988747	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1788C>G; p.S596R; 13:20987992-20987992	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2305C>T; p.R769W; 13:20983401-20983401	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2305C>T; p.R769W; 13:20983401-20983401	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2305C>T; p.R769W; 13:20983401-20983401	large_intestine; colon	carcinoma	Substitution - Missense
c.2305C>T; p.R769W; 13:20983401-20983401	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2645C>T; p.P882L; 13:20981486-20981486	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1771G>T; p.E591*; 13:20988009-20988009	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1771G>T; p.E591*; 13:20988009-20988009	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1771G>T; p.E591*; 13:20988009-20988009	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1771G>T; p.E591*; 13:20988009-20988009	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1771G>T; p.E591*; 13:20988009-20988009	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1243C>T; p.R415W; 13:20988537-20988537	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2582C>T; p.A861V; 13:20981549-20981549	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1861G>C; p.V621L; 13:20987919-20987919	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.387C>T; p.I129I; 13:20991360-20991360	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2568C>T; p.T856T; 13:20981563-20981563	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1696G>T; p.G566C; 13:20988084-20988084	prostate	carcinoma	Substitution - Missense
c.3127C>T; p.R1043*; 13:20975010-20975010	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2967C>T; p.Y989Y; 13:20975170-20975170	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.602_603CC>TT; p.P201L; 13:20989177-20989178	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.81A>G; p.K27K; 13:21045946-21045946	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2063T>G; p.V688G; 13:20983643-20983643	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2186T>A; p.V729D; 13:20983520-20983520	central_nervous_system; brain	glioma	Substitution - Missense
c.2174A>G; p.N725S; 13:20983532-20983532	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3011C>T; p.P1004L; 13:20975126-20975126	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2587A>G; p.K863E; 13:20981544-20981544	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2857T>G; p.C953G; 13:20975280-20975280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.120A>G; p.G40G; 13:21045907-21045907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.120A>G; p.G40G; 13:21045907-21045907	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.926C>T; p.A309V; 13:20988854-20988854	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2713G>A; p.E905K; 13:20979750-20979750	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1611C>T; p.C537C; 13:20988169-20988169	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2859C>A; p.C953*; 13:20975278-20975278	ovary	carcinoma; mucinous_carcinoma	Substitution - Nonsense
c.2859C>A; p.C953*; 13:20975278-20975278	ovary	carcinoma; mucinous_carcinoma	Substitution - Nonsense
c.284C>T; p.A95V; 13:21045743-21045743	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1547C>T; p.P516L; 13:20988233-20988233	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1547C>T; p.P516L; 13:20988233-20988233	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424C>A; p.L142M; 13:20991323-20991323	haematopoietic_and_lymphoid_tissue; small_intestine	lymphoid_neoplasm; enteropathy_type_T_cell_lymphoma	Substitution - Missense
c.2126A>G; p.Q709R; 13:20983580-20983580	kidney	other; neoplasm	Substitution - Missense
c.1650G>T; p.E550D; 13:20988130-20988130	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.47G>A; p.R16Q; 13:21045980-21045980	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2494A>G; p.R832G; 13:20981637-20981637	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation