lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	23705
Symbol	CADM1
Synonymous	BL2\|IGSF4\|IGSF4A\|NECL2\|Necl-2\|RA175\|ST17\|SYNCAM\|TSLC1\|sTSLC-1\|sgIGSF\|synCAM1
Full name	cell adhesion molecule 1
Gene description	TSLC-1\|TSLC1/Nectin-like 2/IGSF4\|immunoglobulin superfamily member 4\|immunoglobulin superfamily, member 4\|immunoglobulin superfamily, member 4D variant 1\|immunoglobulin superfamily, member 4D variant 2\|nectin-like 2\|nectin-like protein 2\|spermatogenic imm
Cytoband	11q23.2
Gene type	protein-coding
Synonymous	MIM:605686; HGNC:HGNC:5951; Ensembl:ENSG00000182985; HPRD:05746; Vega:OTTHUMG00000168202

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.427C>A; p.P143T; 11:115231488-115231488	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.614T>C; p.L205P; 11:115229220-115229220	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.135G>T; p.Q45H; 11:115240410-115240410	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.998C>A; p.P333H; 11:115209654-115209654	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>A; p.V52M; 11:115240391-115240391	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1087G>T; p.A363S; 11:115178767-115178767	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.477T>C; p.G159G; 11:115231438-115231438	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.531C>T; p.I177I; 11:115231384-115231384	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.874G>A; p.V292I; 11:115214728-115214728	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1255G>C; p.D419H; 11:115176548-115176548	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1029C>A; p.T343T; 11:115209623-115209623	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	central_nervous_system; brain	glioma	Substitution - coding silent
c.1029C>A; p.T343T; 11:115209623-115209623	central_nervous_system; brain	glioma	Substitution - coding silent
c.1146G>A; p.A382A; 11:115178708-115178708	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.712G>T; p.E238*; 11:115229122-115229122	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.301A>C; p.N101H; 11:115238623-115238623	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.337A>G; p.N113D; 11:115238587-115238587	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.619C>T; p.L207L; 11:115229215-115229215	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.107C>T; p.A36V; 11:115504288-115504288	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1329G>T; p.*443Y; 11:115176474-115176474	prostate	carcinoma; adenocarcinoma	Nonstop extension
c.454C>T; p.Q152*; 11:115231461-115231461	skin	malignant_melanoma	Substitution - Nonsense
c.352G>C; p.D118H; 11:115238572-115238572	breast	carcinoma	Substitution - Missense
c.850G>A; p.D284N; 11:115214752-115214752	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.302A>G; p.N101S; 11:115238622-115238622	central_nervous_system; brain	glioma	Substitution - Missense
c.1058_1060delCCA; p.T353delT; 11:115209592-115209594	breast	carcinoma	Deletion - In frame
c.1058_1060delCCA; p.T353delT; 11:115209592-115209594	breast	carcinoma	Deletion - In frame
c.1058_1060delCCA; p.T353delT; 11:115209592-115209594	NS	malignant_melanoma	Deletion - In frame
c.1058_1060delCCA; p.T353delT; 11:115209592-115209594	NS	malignant_melanoma	Deletion - In frame
c.908T>A; p.L303Q; 11:115214694-115214694	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.908T>A; p.L303Q; 11:115214694-115214694	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.218T>C; p.V73A; 11:115240327-115240327	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.467C>T; p.A156V; 11:115231448-115231448	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.467C>T; p.A156V; 11:115231448-115231448	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.489A>C; p.E163D; 11:115231426-115231426	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.481G>A; p.E161K; 11:115231434-115231434	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.672C>T; p.H224H; 11:115229162-115229162	skin	malignant_melanoma	Substitution - coding silent
c.495C>A; p.N165K; 11:115231420-115231420	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.740T>A; p.I247N; 11:115217973-115217973	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1248C>T; p.D416D; 11:115176555-115176555	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1248C>T; p.D416D; 11:115176555-115176555	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1034C>A; p.T345N; 11:115209618-115209618	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1158C>T; p.F386F; 11:115178696-115178696	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1035C>T; p.T345T; 11:115209617-115209617	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.935G>A; p.R312H; 11:115214667-115214667	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.303_304insC; p.F102fs*3; 11:115238620-115238621	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.935G>A; p.R312H; 11:115214667-115214667	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.433C>T; p.R145C; 11:115231482-115231482	pancreas	carcinoma	Substitution - Missense
c.703C>T; p.R235W; 11:115229131-115229131	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1060_1061insCCA; p.T353_I354insT; 11:115209591-115209592	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Insertion - In frame
c.1060_1061insCCA; p.T353_I354insT; 11:115209591-115209592	liver	carcinoma; hepatocellular_carcinoma	Insertion - In frame
c.1085G>A; p.R362Q; 11:115178769-115178769	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.520G>A; p.A174T; 11:115231395-115231395	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.189T>G; p.S63R; 11:115240356-115240356	oesophagus	carcinoma	Substitution - Missense
c.921T>C; p.D307D; 11:115214681-115214681	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.639C>T; p.D213D; 11:115229195-115229195	liver	carcinoma	Substitution - coding silent
c.1283_1285delAAG; p.E428delE; 11:115176518-115176520	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Deletion - In frame
c.598A>T; p.T200S; 11:115229236-115229236	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1258G>A; p.A420T; 11:115176545-115176545	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1258G>A; p.A420T; 11:115176545-115176545	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.687A>G; p.G229G; 11:115229147-115229147	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.78_83delCCGGCT; p.R27_L28delRL; 11:115504312-115504317	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - In frame
c.78_83delCCGGCT; p.R27_L28delRL; 11:115504312-115504317	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - In frame
c.78_83delCCGGCT; p.R27_L28delRL; 11:115504312-115504317	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.781G>A; p.D261N; 11:115217932-115217932	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.890A>G; p.N297S; 11:115214712-115214712	skin	malignant_melanoma	Substitution - Missense
c.78_83delCCGGCT; p.R27_L28delRL; 11:115504312-115504317	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - In frame
c.78_83delCCGGCT; p.R27_L28delRL; 11:115504312-115504317	skin	malignant_melanoma	Deletion - In frame
c.78_83delCCGGCT; p.R27_L28delRL; 11:115504312-115504317	breast	carcinoma	Deletion - In frame
c.78_83delCCGGCT; p.R27_L28delRL; 11:115504312-115504317	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.531C>G; p.I177M; 11:115231384-115231384	thyroid	carcinoma	Substitution - Missense
c.1189C>T; p.R397C; 11:115178665-115178665	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.179C>T; p.A60V; 11:115240366-115240366	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.884G>A; p.G295E; 11:115214718-115214718	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.579A>T; p.E193D; 11:115229255-115229255	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1238G>A; p.G413E; 11:115176565-115176565	skin	malignant_melanoma	Substitution - Missense
c.271C>T; p.P91S; 11:115240274-115240274	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.248C>G; p.T83S; 11:115240297-115240297	oesophagus	carcinoma	Substitution - Missense
c.13G>C; p.V5L; 11:115504382-115504382	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1007C>A; p.T336N; 11:115209645-115209645	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.13G>C; p.V5L; 11:115504382-115504382	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.649C>A; p.P217T; 11:115229185-115229185	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.810C>T; p.I270I; 11:115217903-115217903	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.439C>A; p.L147M; 11:115231476-115231476	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1178T>C; p.I393T; 11:115178676-115178676	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.749C>T; p.T250I; 11:115217964-115217964	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.439C>A; p.L147M; 11:115231476-115231476	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>T; p.V239L; 11:115229119-115229119	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.176T>C; p.V59A; 11:115240369-115240369	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.685G>A; p.G229R; 11:115229149-115229149	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.434G>A; p.R145H; 11:115231481-115231481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.64C>T; p.P22S; 11:115504331-115504331	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.490G>A; p.V164I; 11:115231425-115231425	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.490G>A; p.V164I; 11:115231425-115231425	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.865C>G; p.Q289E; 11:115214737-115214737	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1133G>T; p.G378V; 11:115178721-115178721	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1236A>G; p.K412K; 11:115176567-115176567	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.502G>A; p.A168T; 11:115231413-115231413	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.124G>A; p.G42S; 11:115504271-115504271	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.785C>T; p.A262V; 11:115217928-115217928	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1224T>C; p.T408T; 11:115176579-115176579	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.213C>A; p.D71E; 11:115240332-115240332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.784G>A; p.A262T; 11:115217929-115217929	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.652G>T; p.V218L; 11:115229182-115229182	liver	carcinoma	Substitution - Missense
c.769A>C; p.T257P; 11:115217944-115217944	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.678G>A; p.A226A; 11:115229156-115229156	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1147G>T; p.V383L; 11:115178707-115178707	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.739A>G; p.I247V; 11:115217974-115217974	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.472G>C; p.E158Q; 11:115231443-115231443	breast	carcinoma	Substitution - Missense
c.1174C>T; p.L392F; 11:115178680-115178680	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1140C>T; p.V380V; 11:115178714-115178714	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.156G>T; p.V52V; 11:115240389-115240389	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.156G>T; p.V52V; 11:115240389-115240389	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.385G>A; p.D129N; 11:115238539-115238539	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.448G>A; p.D150N; 11:115231467-115231467	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1323C>A; p.F441L; 11:115176480-115176480	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.463A>G; p.T155A; 11:115231452-115231452	liver	carcinoma	Substitution - Missense
c.1286G>A; p.G429E; 11:115176517-115176517	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.569C>T; p.S190L; 11:115229265-115229265	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.569C>T; p.S190L; 11:115229265-115229265	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.569C>T; p.S190L; 11:115229265-115229265	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.569C>T; p.S190L; 11:115229265-115229265	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.186C>T; p.I62I; 11:115240359-115240359	breast	carcinoma	Substitution - coding silent
c.187A>C; p.S63R; 11:115240358-115240358	large_intestine; colon	NS	Substitution - Missense
c.704G>A; p.R235Q; 11:115229130-115229130	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.704G>A; p.R235Q; 11:115229130-115229130	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.165C>T; p.I55I; 11:115240380-115240380	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.795A>G; p.L265L; 11:115217918-115217918	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - coding silent
c.814A>G; p.K272E; 11:115217899-115217899	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation