lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	23239
Symbol	PHLPP1
Synonymous	PHLPP\|PLEKHE1\|SCOP
Full name	PH domain and leucine rich repeat protein phosphatase 1
Gene description	PH domain leucine-rich repeat-containing protein phosphatase 1\|PH domain-containing family E member 1\|SCN circadian oscillatory protein\|pleckstrin homology domain containing, family E (with leucine rich repeats) member 1\|suprachiasmatic nucleus circadian
Cytoband	18q21.33
Gene type	protein-coding
Synonymous	MIM:609396; HGNC:HGNC:20610; Ensembl:ENSG00000081913; HPRD:15145; Vega:OTTHUMG00000150629

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.4714A>C; p.S1572R; 18:62978991-62978991	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4183G>T; p.A1395S; 18:62978460-62978460	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.2236G>T; p.G746*; 18:62895803-62895803	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.4016C>T; p.T1339M; 18:62978293-62978293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749A>T; p.Q250L; 18:62716432-62716432	liver	carcinoma	Substitution - Missense
c.749A>T; p.Q250L; 18:62716432-62716432	liver	carcinoma	Substitution - Missense
c.2452G>A; p.V818I; 18:62902971-62902971	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4922C>T; p.T1641I; 18:62979199-62979199	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1864A>T; p.T622S; 18:62838874-62838874	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2179C>T; p.R727*; 18:62895123-62895123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2179C>T; p.R727*; 18:62895123-62895123	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.4994T>C; p.I1665T; 18:62979271-62979271	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4719G>T; p.R1573R; 18:62978996-62978996	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.4721C>T; p.A1574V; 18:62978998-62978998	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.4499C>T; p.P1500L; 18:62978776-62978776	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2245C>A; p.L749I; 18:62895812-62895812	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4856G>T; p.G1619V; 18:62979133-62979133	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4927G>A; p.A1643T; 18:62979204-62979204	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.4927G>A; p.A1643T; 18:62979204-62979204	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1544C>G; p.S515W; 18:62717227-62717227	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4908G>A; p.V1636V; 18:62979185-62979185	breast	carcinoma	Substitution - coding silent
c.4936C>T; p.R1646*; 18:62979213-62979213	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.4936C>T; p.R1646*; 18:62979213-62979213	skin	malignant_melanoma	Substitution - Nonsense
c.3500C>T; p.A1167V; 18:62963412-62963412	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.621C>T; p.F207F; 18:62716304-62716304	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3817G>A; p.D1273N; 18:62975458-62975458	breast	carcinoma	Substitution - Missense
c.3645G>A; p.V1215V; 18:62972598-62972598	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.4425C>T; p.S1475S; 18:62978702-62978702	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1971C>A; p.F657L; 18:62860506-62860506	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2197G>A; p.V733I; 18:62895141-62895141	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2197G>A; p.V733I; 18:62895141-62895141	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.3749T>C; p.M1250T; 18:62972702-62972702	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2397G>C; p.R799S; 18:62895964-62895964	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1678C>T; p.R560C; 18:62830136-62830136	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1678C>T; p.R560C; 18:62830136-62830136	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1949A>T; p.E650V; 18:62860484-62860484	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1678C>T; p.R560C; 18:62830136-62830136	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4620C>G; p.F1540L; 18:62978897-62978897	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1937G>C; p.C646S; 18:62860472-62860472	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.4512C>T; p.S1504S; 18:62978789-62978789	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.4512C>T; p.S1504S; 18:62978789-62978789	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3087G>A; p.V1029V; 18:62941844-62941844	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.3174A>C; p.K1058N; 18:62945121-62945121	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2596A>G; p.T866A; 18:62903115-62903115	liver	carcinoma	Substitution - Missense
c.3618T>C; p.Y1206Y; 18:62972571-62972571	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3529G>T; p.G1177C; 18:62963441-62963441	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3256C>T; p.H1086Y; 18:62945203-62945203	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.5053_5055delCAG; p.Q1689delQ; 18:62979330-62979332	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - In frame
c.5053_5055delCAG; p.Q1689delQ; 18:62979330-62979332	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.2960+4A>C; p.?; 18:62920118-62920118	liver	carcinoma	Unknown
c.2960+4A>C; p.?; 18:62920118-62920118	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1569C>G; p.F523L; 18:62717252-62717252	breast	carcinoma	Substitution - Missense
c.4413C>T; p.S1471S; 18:62978690-62978690	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1776_1778delAGA; p.E594delE; 18:62838786-62838788	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.4726G>A; p.E1576K; 18:62979003-62979003	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2437G>T; p.D813Y; 18:62896004-62896004	bone; femur	chondrosarcoma	Substitution - Missense
c.4061G>A; p.R1354H; 18:62978338-62978338	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.3007C>T; p.P1003S; 18:62941764-62941764	skin	malignant_melanoma	Substitution - Missense
c.3059C>G; p.T1020R; 18:62941816-62941816	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1910A>T; p.Q637L; 18:62860445-62860445	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.3376delC; p.L1126fs*8; 18:62958680-62958680	soft_tissue; striated_muscle	rhabdomyosarcoma; alveolar	Deletion - Frameshift
c.3316G>C; p.E1106Q; 18:62945263-62945263	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2829G>A; p.R943R; 18:62919983-62919983	breast	carcinoma	Substitution - coding silent
c.2242T>G; p.F748V; 18:62895809-62895809	breast	carcinoma	Substitution - Missense
c.4416C>T; p.G1472G; 18:62978693-62978693	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.4826A>C; p.K1609T; 18:62979103-62979103	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.3027G>C; p.E1009D; 18:62941784-62941784	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3541G>A; p.A1181T; 18:62963453-62963453	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3541G>A; p.A1181T; 18:62963453-62963453	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3541G>A; p.A1181T; 18:62963453-62963453	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4725G>A; p.K1575K; 18:62979002-62979002	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3499G>A; p.A1167T; 18:62963411-62963411	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.4782C>T; p.G1594G; 18:62979059-62979059	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.4496C>T; p.P1499L; 18:62978773-62978773	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1517G>A; p.W506*; 18:62717200-62717200	thyroid	other; neoplasm	Substitution - Nonsense
c.4276G>A; p.E1426K; 18:62978553-62978553	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1066G>A; p.A356T; 18:62716749-62716749	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3849G>C; p.L1283F; 18:62975490-62975490	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1692A>G; p.L564L; 18:62830150-62830150	liver	carcinoma	Substitution - coding silent
c.3253A>C; p.M1085L; 18:62945200-62945200	ovary	other; neoplasm	Substitution - Missense
c.2143A>G; p.T715A; 18:62895087-62895087	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.5004G>A; p.P1668P; 18:62979281-62979281	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.4813G>A; p.G1605S; 18:62979090-62979090	liver	carcinoma	Substitution - Missense
c.4813G>A; p.G1605S; 18:62979090-62979090	liver	carcinoma	Substitution - Missense
c.4484C>T; p.S1495F; 18:62978761-62978761	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3889C>T; p.R1297*; 18:62975530-62975530	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3889C>T; p.R1297*; 18:62975530-62975530	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3889C>T; p.R1297*; 18:62975530-62975530	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.4048A>T; p.S1350C; 18:62978325-62978325	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.3949A>G; p.K1317E; 18:62975590-62975590	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2445-1G>A; p.?; 18:62902963-62902963	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.3400G>C; p.D1134H; 18:62958704-62958704	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1012C>A; p.R338S; 18:62716695-62716695	kidney	other; neoplasm	Substitution - Missense
c.2184A>G; p.S728S; 18:62895128-62895128	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.4665C>T; p.G1555G; 18:62978942-62978942	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.4931C>T; p.P1644L; 18:62979208-62979208	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4348C>T; p.P1450S; 18:62978625-62978625	skin	malignant_melanoma	Substitution - Missense
c.1515G>C; p.L505L; 18:62717198-62717198	thyroid	other; neoplasm	Substitution - coding silent
c.3298G>A; p.E1100K; 18:62945245-62945245	breast	carcinoma	Substitution - Missense
c.2384T>C; p.V795A; 18:62895951-62895951	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3560+2T>C; p.?; 18:62963474-62963474	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.3766A>G; p.T1256A; 18:62975407-62975407	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.4069G>T; p.V1357L; 18:62978346-62978346	liver	carcinoma	Substitution - Missense
c.4069G>T; p.V1357L; 18:62978346-62978346	liver	carcinoma	Substitution - Missense
c.4258G>A; p.V1420M; 18:62978535-62978535	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4952A>G; p.Y1651C; 18:62979229-62979229	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4180G>A; p.D1394N; 18:62978457-62978457	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2648A>T; p.E883V; 18:62905224-62905224	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3817_3818insA; p.D1273fs*15; 18:62975458-62975459	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.4765G>A; p.E1589K; 18:62979042-62979042	breast	carcinoma	Substitution - Missense
c.4297G>A; p.E1433K; 18:62978574-62978574	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2601A>G; p.L867L; 18:62903120-62903120	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3700_3701insA; p.T1236fs*38; 18:62972653-62972654	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.3700_3701insA; p.T1236fs*38; 18:62972653-62972654	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.4464C>T; p.S1488S; 18:62978741-62978741	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2102A>G; p.N701S; 18:62895046-62895046	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1559T>A; p.L520H; 18:62717242-62717242	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.4464C>T; p.S1488S; 18:62978741-62978741	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011C>T; p.P337P; 18:62716694-62716694	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011C>T; p.P337P; 18:62716694-62716694	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2121A>T; p.P707P; 18:62895065-62895065	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.871T>G; p.F291V; 18:62716554-62716554	thyroid	other; neoplasm	Substitution - Missense
c.3917G>T; p.R1306I; 18:62975558-62975558	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3337A>G; p.S1113G; 18:62958641-62958641	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1607G>A; p.R536Q; 18:62830065-62830065	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1546G>T; p.E516*; 18:62717229-62717229	breast	carcinoma	Substitution - Nonsense
c.2956G>A; p.D986N; 18:62920110-62920110	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1753C>A; p.L585M; 18:62830211-62830211	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2682T>A; p.N894K; 18:62905258-62905258	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3809T>A; p.I1270N; 18:62975450-62975450	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1885C>T; p.R629*; 18:62838895-62838895	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3186T>C; p.L1062L; 18:62945133-62945133	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.3799_3804delCTTTGT; p.L1267_C1268delLC; 18:62975440-62975445	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - In frame
c.3750G>T; p.M1250I; 18:62972703-62972703	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.3750G>T; p.M1250I; 18:62972703-62972703	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4104C>A; p.F1368L; 18:62978381-62978381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4163C>T; p.A1388V; 18:62978440-62978440	skin	malignant_melanoma	Substitution - Missense
c.3792C>T; p.A1264A; 18:62975433-62975433	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3239T>G; p.M1080R; 18:62945186-62945186	skin	malignant_melanoma	Substitution - Missense
c.1738G>C; p.G580R; 18:62830196-62830196	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.4620C>T; p.F1540F; 18:62978897-62978897	skin	malignant_melanoma	Substitution - coding silent
c.4325C>A; p.P1442Q; 18:62978602-62978602	thyroid	other; neoplasm	Substitution - Missense
c.1832G>A; p.S611N; 18:62838842-62838842	skin	malignant_melanoma	Substitution - Missense
c.4804G>A; p.D1602N; 18:62979081-62979081	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3604C>T; p.R1202C; 18:62972557-62972557	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.4099G>A; p.E1367K; 18:62978376-62978376	pancreas	carcinoma	Substitution - Missense
c.3976A>G; p.I1326V; 18:62975617-62975617	breast	carcinoma	Substitution - Missense
c.4795G>A; p.A1599T; 18:62979072-62979072	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.4513G>A; p.E1505K; 18:62978790-62978790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3462C>T; p.I1154I; 18:62963374-62963374	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.4305C>T; p.S1435S; 18:62978582-62978582	pancreas	carcinoma	Substitution - coding silent
c.531G>T; p.L177L; 18:62716214-62716214	liver	carcinoma	Substitution - coding silent
c.2336T>G; p.L779W; 18:62895903-62895903	skin	malignant_melanoma	Substitution - Missense
c.1523T>G; p.V508G; 18:62717206-62717206	skin	malignant_melanoma	Substitution - Missense
c.3652C>T; p.P1218S; 18:62972605-62972605	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4246A>G; p.S1416G; 18:62978523-62978523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2977G>A; p.A993T; 18:62941734-62941734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4268G>T; p.S1423I; 18:62978545-62978545	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1937G>A; p.C646Y; 18:62860472-62860472	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2862G>T; p.R954S; 18:62920016-62920016	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1821T>C; p.S607S; 18:62838831-62838831	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1923A>C; p.S641S; 18:62860458-62860458	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2862G>T; p.R954S; 18:62920016-62920016	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2716T>A; p.L906I; 18:62914920-62914920	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2862G>T; p.R954S; 18:62920016-62920016	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.4858C>T; p.R1620C; 18:62979135-62979135	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4629C>T; p.N1543N; 18:62978906-62978906	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3929T>C; p.M1310T; 18:62975570-62975570	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1822G>T; p.G608*; 18:62838832-62838832	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1635C>T; p.V545V; 18:62830093-62830093	skin	malignant_melanoma	Substitution - coding silent
c.2706A>G; p.S902S; 18:62905282-62905282	breast	carcinoma	Substitution - coding silent
c.4196C>T; p.A1399V; 18:62978473-62978473	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4018C>T; p.R1340C; 18:62978295-62978295	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.4308C>T; p.A1436A; 18:62978585-62978585	breast	carcinoma	Substitution - coding silent
c.491C>T; p.S164L; 18:62716174-62716174	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3245G>A; p.C1082Y; 18:62945192-62945192	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3492A>G; p.T1164T; 18:62963404-62963404	liver	carcinoma	Substitution - coding silent
c.3833G>A; p.G1278E; 18:62975474-62975474	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4543C>T; p.R1515C; 18:62978820-62978820	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation