Cancer metastasis database

Annotation category 5

Gene information

Gene ID 2237
Symbol

FEN1

Synonymous

FEN-1|MF1|RAD2

Full name

flap structure-specific endonuclease 1

Gene description

DNase IV|FEN-1|flap endonuclease 1|maturation factor 1|maturation factor-1

Cytoband

11q12

Gene type

protein-coding

Synonymous

MIM:600393; HGNC:HGNC:3650; Ensembl:ENSG00000168496; HPRD:02670; Vega:OTTHUMG00000168162

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.105C>A; p.A35A; 11:61795466-61795466

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.658C>A; p.Q220K; 11:61796019-61796019

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.217C>T; p.R73C; 11:61795578-61795578

 breastcarcinomaSubstitution - Missense

c.994C>A; p.R332S; 11:61796355-61796355

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1064G>A; p.R355H; 11:61796425-61796425

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.107C>T; p.S36F; 11:61795468-61795468

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.959G>A; p.R320Q; 11:61796320-61796320

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.285C>T; p.G95G; 11:61795646-61795646

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.733C>T; p.R245W; 11:61796094-61796094

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.134C>T; p.A45V; 11:61795495-61795495

 breastcarcinomaSubstitution - Missense

c.82G>T; p.G28C; 11:61795443-61795443

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.607C>T; p.P203S; 11:61795968-61795968

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.641A>C; p.Q214P; 11:61796002-61796002

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.953A>T; p.E318V; 11:61796314-61796314

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.788T>A; p.L263H; 11:61796149-61796149

 breastcarcinomaSubstitution - Missense

c.958C>T; p.R320*; 11:61796319-61796319

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.197G>A; p.G66D; 11:61795558-61795558

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.243C>A; p.P81P; 11:61795604-61795604

 livercarcinomaSubstitution - coding silent

c.165T>C; p.N55N; 11:61795526-61795526

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.392T>G; p.V131G; 11:61795753-61795753

 soft_tissue; striated_musclerhabdomyosarcoma; alveolarSubstitution - Missense

c.1079C>T; p.P360L; 11:61796440-61796440

 skinmalignant_melanomaSubstitution - Missense

c.993C>T; p.S331S; 11:61796354-61796354

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.986G>A; p.S329N; 11:61796347-61796347

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.733C>G; p.R245G; 11:61796094-61796094

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.825C>T; p.L275L; 11:61796186-61796186

 skinmalignant_melanomaSubstitution - coding silent

c.999A>T; p.Q333H; 11:61796360-61796360

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.684C>T; p.I228I; 11:61796045-61796045

 skinmalignant_melanomaSubstitution - coding silent

c.1040C>T; p.T347I; 11:61796401-61796401

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1016G>A; p.R339H; 11:61796377-61796377

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.60G>T; p.E20D; 11:61795421-61795421

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.806C>T; p.P269L; 11:61796167-61796167

 skinmalignant_melanomaSubstitution - Missense

c.626T>C; p.L209P; 11:61795987-61795987

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.356C>T; p.A119V; 11:61795717-61795717

 skinmalignant_melanomaSubstitution - Missense