lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2150
Symbol	F2RL1
Synonymous	GPR11\|PAR2
Full name	coagulation factor II (thrombin) receptor-like 1
Gene description	G-protein coupled receptor 11\|coagulation factor II receptor-like 1\|protease-activated receptor 2\|proteinase-activated receptor 2\|thrombin receptor-like 1
Cytoband	5q13
Gene type	protein-coding
Synonymous	MIM:600933; HGNC:HGNC:3538; Ensembl:ENSG00000164251; HPRD:02960; Vega:OTTHUMG00000102118

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.992G>A; p.C331Y; 5:76833599-76833599	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.992G>A; p.C331Y; 5:76833599-76833599	large_intestine; colon	carcinoma	Substitution - Missense
c.992G>A; p.C331Y; 5:76833599-76833599	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.549C>T; p.H183H; 5:76833156-76833156	thyroid	carcinoma	Substitution - coding silent
c.491T>A; p.L164H; 5:76833098-76833098	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.290T>A; p.L97Q; 5:76832897-76832897	skin	malignant_melanoma	Substitution - Missense
c.966C>A; p.V322V; 5:76833573-76833573	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1151G>T; p.S384I; 5:76833758-76833758	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.83G>T; p.G28V; 5:76832690-76832690	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.472A>T; p.N158Y; 5:76833079-76833079	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.194C>T; p.S65F; 5:76832801-76832801	skin	malignant_melanoma	Substitution - Missense
c.568A>G; p.I190V; 5:76833175-76833175	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1048G>C; p.D350H; 5:76833655-76833655	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1071C>T; p.N357N; 5:76833678-76833678	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.174C>A; p.V58V; 5:76832781-76832781	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1029C>T; p.V343V; 5:76833636-76833636	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.826G>A; p.E276K; 5:76833433-76833433	skin	malignant_melanoma	Substitution - Missense
c.397G>A; p.A133T; 5:76833004-76833004	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.818C>T; p.A273V; 5:76833425-76833425	central_nervous_system; brain	glioma	Substitution - Missense
c.937C>T; p.L313L; 5:76833544-76833544	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.840G>T; p.K280N; 5:76833447-76833447	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.531C>T; p.I177I; 5:76833138-76833138	skin	malignant_melanoma	Substitution - coding silent
c.345C>T; p.A115A; 5:76832952-76832952	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.750C>A; p.V250V; 5:76833357-76833357	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1083C>T; p.C361C; 5:76833690-76833690	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.519G>A; p.R173R; 5:76833126-76833126	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.678T>C; p.C226C; 5:76833285-76833285	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.677G>T; p.C226F; 5:76833284-76833284	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.676T>C; p.C226R; 5:76833283-76833283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.676T>C; p.C226R; 5:76833283-76833283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.676T>C; p.C226R; 5:76833283-76833283	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.676T>C; p.C226R; 5:76833283-76833283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.676T>C; p.C226R; 5:76833283-76833283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.676T>C; p.C226R; 5:76833283-76833283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.676T>C; p.C226R; 5:76833283-76833283	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.367C>T; p.L123F; 5:76832974-76832974	skin	malignant_melanoma	Substitution - Missense
c.308G>A; p.R103Q; 5:76832915-76832915	skin	malignant_melanoma	Substitution - Missense
c.308G>A; p.R103Q; 5:76832915-76832915	breast	carcinoma	Substitution - Missense
c.308G>A; p.R103Q; 5:76832915-76832915	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.633C>G; p.V211V; 5:76833240-76833240	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1081T>A; p.C361S; 5:76833688-76833688	skin	malignant_melanoma	Substitution - Missense
c.603G>T; p.L201L; 5:76833210-76833210	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.427T>A; p.Y143N; 5:76833034-76833034	skin	malignant_melanoma	Substitution - Missense
c.545G>A; p.G182E; 5:76833152-76833152	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1056G>A; p.R352R; 5:76833663-76833663	skin	malignant_melanoma	Substitution - coding silent
c.344C>T; p.A115V; 5:76832951-76832951	skin	malignant_melanoma	Substitution - Missense
c.1143G>A; p.R381R; 5:76833750-76833750	skin	malignant_melanoma	Substitution - coding silent
c.1143G>A; p.R381R; 5:76833750-76833750	skin	malignant_melanoma	Substitution - coding silent
c.301C>A; p.L101I; 5:76832908-76832908	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.677G>C; p.C226S; 5:76833284-76833284	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.426T>A; p.I142I; 5:76833033-76833033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.231C>T; p.F77F; 5:76832838-76832838	skin	malignant_melanoma	Substitution - coding silent
c.231C>T; p.F77F; 5:76832838-76832838	skin	malignant_melanoma	Substitution - coding silent
c.231C>T; p.F77F; 5:76832838-76832838	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.465C>G; p.F155L; 5:76833072-76833072	urinary_tract; bladder	carcinoma	Substitution - Missense
c.405C>T; p.H135H; 5:76833012-76833012	bone; pelvis	chondrosarcoma	Substitution - coding silent
c.798C>T; p.I266I; 5:76833405-76833405	skin	malignant_melanoma	Substitution - coding silent
c.835G>C; p.E279Q; 5:76833442-76833442	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.269T>C; p.L90S; 5:76832876-76832876	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.769C>A; p.L257I; 5:76833376-76833376	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.280G>T; p.G94C; 5:76832887-76832887	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1018G>A; p.D340N; 5:76833625-76833625	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.930T>C; p.H310H; 5:76833537-76833537	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.279C>T; p.N93N; 5:76832886-76832886	breast	carcinoma	Substitution - coding silent
c.279C>T; p.N93N; 5:76832886-76832886	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.78C>A; p.I26I; 5:76819260-76819260	thyroid	other; neoplasm	Substitution - coding silent
c.463T>A; p.F155I; 5:76833070-76833070	skin	malignant_melanoma	Substitution - Missense
c.675C>A; p.T225T; 5:76833282-76833282	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.634G>T; p.V212L; 5:76833241-76833241	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.808C>T; p.R270*; 5:76833415-76833415	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.808C>T; p.R270*; 5:76833415-76833415	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.808C>T; p.R270*; 5:76833415-76833415	skin	malignant_melanoma	Substitution - Nonsense
c.164T>C; p.V55A; 5:76832771-76832771	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.890T>C; p.L297P; 5:76833497-76833497	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.890T>C; p.L297P; 5:76833497-76833497	large_intestine; colon	carcinoma	Substitution - Missense
c.890T>C; p.L297P; 5:76833497-76833497	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1085G>A; p.R362Q; 5:76833692-76833692	skin; trunk	malignant_melanoma	Substitution - Missense
c.299T>G; p.F100C; 5:76832906-76832906	pancreas	carcinoma	Substitution - Missense
c.546G>A; p.G182G; 5:76833153-76833153	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.754C>T; p.L252L; 5:76833361-76833361	skin	malignant_melanoma	Substitution - coding silent
c.74C>T; p.T25I; 5:76819256-76819256	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.672G>A; p.T224T; 5:76833279-76833279	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.660C>A; p.A220A; 5:76833267-76833267	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.179C>G; p.S60C; 5:76832786-76832786	urinary_tract; bladder	carcinoma	Substitution - Missense
c.376A>G; p.I126V; 5:76832983-76832983	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.747G>A; p.G249G; 5:76833354-76833354	breast	carcinoma	Substitution - coding silent
c.1093C>T; p.R365C; 5:76833700-76833700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.89G>A; p.S30N; 5:76832696-76832696	thyroid	other; neoplasm	Substitution - Missense
c.1111C>T; p.Q371*; 5:76833718-76833718	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1094G>A; p.R365H; 5:76833701-76833701	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1094G>A; p.R365H; 5:76833701-76833701	central_nervous_system; brain	glioma	Substitution - Missense
c.82+5G>A; p.?; 5:76819269-76819269	liver	carcinoma	Unknown
c.809G>A; p.R270Q; 5:76833416-76833416	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation