lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2147
Symbol	F2
Synonymous	PT\|RPRGL2\|THPH1
Full name	coagulation factor II (thrombin)
Gene description	prepro-coagulation factor II\|prothrombin\|prothrombin B-chain\|serine protease
Cytoband	11p11
Gene type	protein-coding
Synonymous	MIM:176930; HGNC:HGNC:3535; Ensembl:ENSG00000180210; HPRD:01488; Vega:OTTHUMG00000150344

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.573C>A; p.V191V; 11:46725872-46725872	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.390G>A; p.Q130Q; 11:46723253-46723253	pancreas	carcinoma	Substitution - coding silent
c.1524G>A; p.K508K; 11:46729431-46729431	skin	malignant_melanoma	Substitution - coding silent
c.1524G>A; p.K508K; 11:46729431-46729431	skin	malignant_melanoma	Substitution - coding silent
c.1530G>A; p.T510T; 11:46729437-46729437	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1127C>T; p.P376L; 11:46726834-46726834	skin	malignant_melanoma	Substitution - Missense
c.1479C>T; p.L493L; 11:46729386-46729386	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1495G>A; p.G499R; 11:46729402-46729402	skin	malignant_melanoma	Substitution - Missense
c.1603G>T; p.V535F; 11:46729510-46729510	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1869delG; p.*623fs?; 11:46739408-46739408	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.829G>C; p.A277P; 11:46726128-46726128	central_nervous_system; brain	glioma	Substitution - Missense
c.189G>C; p.E63D; 11:46719811-46719811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.249C>A; p.F83L; 11:46720531-46720531	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.555C>T; p.V185V; 11:46723514-46723514	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.869A>G; p.Y290C; 11:46726168-46726168	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.450C>T; p.A150A; 11:46723409-46723409	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.I372I; 11:46726823-46726823	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.500C>A; p.P167H; 11:46723459-46723459	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1116C>T; p.I372I; 11:46726823-46726823	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.785G>A; p.C262Y; 11:46726084-46726084	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1299-1G>A; p.?; 11:46728663-46728663	skin	malignant_melanoma	Unknown
c.798C>T; p.D266D; 11:46726097-46726097	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.403C>T; p.R135C; 11:46723266-46723266	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.978G>A; p.P326P; 11:46726601-46726601	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.328G>A; p.E110K; 11:46723191-46723191	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.933C>T; p.I311I; 11:46726556-46726556	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.103C>G; p.R35G; 11:46719725-46719725	breast	carcinoma	Substitution - Missense
c.520C>T; p.P174S; 11:46723479-46723479	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1347C>T; p.I449I; 11:46728712-46728712	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.822C>T; p.C274C; 11:46726121-46726121	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.284C>T; p.T95M; 11:46720808-46720808	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1457G>T; p.R486M; 11:46728822-46728822	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.592C>T; p.R198C; 11:46725891-46725891	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.813C>T; p.G271G; 11:46726112-46726112	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1118G>A; p.G373D; 11:46726825-46726825	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.187G>A; p.E63K; 11:46719809-46719809	central_nervous_system; brainstem	glioma; oligoastrocytoma_Grade_III	Substitution - Missense
c.1339A>T; p.I447F; 11:46728704-46728704	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1339A>T; p.I447F; 11:46728704-46728704	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1052C>T; p.T351I; 11:46726759-46726759	skin	malignant_melanoma	Substitution - Missense
c.530G>T; p.R177M; 11:46723489-46723489	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1439C>A; p.P480H; 11:46728804-46728804	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.861C>A; p.D287E; 11:46726160-46726160	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1411C>G; p.P471A; 11:46728776-46728776	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1411C>G; p.P471A; 11:46728776-46728776	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1765T>C; p.S589P; 11:46739304-46739304	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.602G>A; p.G201D; 11:46725901-46725901	skin	malignant_melanoma	Substitution - Missense
c.1640A>G; p.N547S; 11:46729547-46729547	pancreas	carcinoma	Substitution - Missense
c.1015_1025del11; p.P340fs*55; 11:46726722-46726732	breast	carcinoma	Deletion - Frameshift
c.846C>T; p.D282D; 11:46726145-46726145	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.6G>A; p.A2A; 11:46719241-46719241	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.495G>T; p.T165T; 11:46723454-46723454	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1203C>T; p.V401V; 11:46728068-46728068	skin	malignant_melanoma	Substitution - coding silent
c.1525G>A; p.E509K; 11:46729432-46729432	skin; neck	malignant_melanoma	Substitution - Missense
c.799_800GG>AA; p.G267K; 11:46726098-46726099	skin	malignant_melanoma	Substitution - Missense
c.253G>A; p.A85T; 11:46720535-46720535	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1508G>C; p.G503A; 11:46729415-46729415	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.390G>T; p.Q130H; 11:46723253-46723253	liver	carcinoma	Substitution - Missense
c.390G>T; p.Q130H; 11:46723253-46723253	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.154C>T; p.R52C; 11:46719776-46719776	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.154C>T; p.R52C; 11:46719776-46719776	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.491C>T; p.T164I; 11:46723450-46723450	skin	malignant_melanoma	Substitution - Missense
c.582G>A; p.A194A; 11:46725881-46725881	skin	malignant_melanoma	Substitution - coding silent
c.833G>A; p.G278E; 11:46726132-46726132	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1015C>T; p.R339*; 11:46726722-46726722	ovary	other; neoplasm	Substitution - Nonsense
c.651G>A; p.R217R; 11:46725950-46725950	skin	malignant_melanoma	Substitution - coding silent
c.1407G>T; p.K469N; 11:46728772-46728772	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1326C>A; p.S442S; 11:46728691-46728691	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.448G>T; p.A150S; 11:46723407-46723407	breast	carcinoma	Substitution - Missense
c.1628G>T; p.R543L; 11:46729535-46729535	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.755A>G; p.N252S; 11:46726054-46726054	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1529C>T; p.T510M; 11:46729436-46729436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.473G>A; p.R158H; 11:46723432-46723432	pancreas	carcinoma	Substitution - Missense
c.1549A>G; p.K517E; 11:46729456-46729456	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1274G>A; p.R425H; 11:46728139-46728139	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1212C>T; p.A404A; 11:46728077-46728077	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.617_618delTG; p.S207fs*9; 11:46725916-46725917	liver	carcinoma	Deletion - Frameshift
c.491C>G; p.T164S; 11:46723450-46723450	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.41C>G; p.A14G; 11:46719276-46719276	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1051A>C; p.T351P; 11:46726758-46726758	pancreas	carcinoma	Substitution - Missense
c.916G>A; p.D306N; 11:46726539-46726539	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1195C>T; p.R399C; 11:46728060-46728060	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1185C>T; p.L395L; 11:46728050-46728050	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1112A>T; p.E371V; 11:46726819-46726819	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1788G>A; p.R596R; 11:46739327-46739327	skin	malignant_melanoma	Substitution - coding silent
c.289C>A; p.R97R; 11:46720813-46720813	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; essential_thrombocythaemia	Substitution - coding silent
c.459G>A; p.Q153Q; 11:46723418-46723418	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1213G>A; p.A405T; 11:46728078-46728078	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1544T>C; p.V515A; 11:46729451-46729451	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1005C>T; p.D335D; 11:46726712-46726712	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1728C>T; p.S576S; 11:46739267-46739267	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1728C>T; p.S576S; 11:46739267-46739267	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1728C>T; p.S576S; 11:46739267-46739267	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1728C>T; p.S576S; 11:46739267-46739267	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1367G>A; p.R456Q; 11:46728732-46728732	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.526G>A; p.V176M; 11:46723485-46723485	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.526G>A; p.V176M; 11:46723485-46723485	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.526G>A; p.V176M; 11:46723485-46723485	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.533G>A; p.R178K; 11:46723492-46723492	skin	malignant_melanoma	Substitution - Missense
c.1598G>A; p.R533Q; 11:46729505-46729505	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.1762G>A; p.V588I; 11:46739301-46739301	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.718G>T; p.A240S; 11:46726017-46726017	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.240+1G>A; p.?; 11:46719863-46719863	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.934G>A; p.E312K; 11:46726557-46726557	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1233G>A; p.P411P; 11:46728098-46728098	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1841_1843delAGA; p.K615delK; 11:46739380-46739382	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1054G>A; p.E352K; 11:46726761-46726761	prostate	carcinoma	Substitution - Missense
c.1312A>T; p.I438F; 11:46728677-46728677	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1320G>T; p.K440N; 11:46728685-46728685	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1157C>T; p.P386L; 11:46728022-46728022	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.832G>A; p.G278R; 11:46726131-46726131	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1411C>T; p.P471S; 11:46728776-46728776	skin	malignant_melanoma	Substitution - Missense
c.462G>T; p.E154D; 11:46723421-46723421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1411C>T; p.P471S; 11:46728776-46728776	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1393C>A; p.L465M; 11:46728758-46728758	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1474T>G; p.L492V; 11:46729381-46729381	large_intestine; colon	NS	Substitution - Missense
c.1749T>G; p.Y583*; 11:46739288-46739288	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1810A>G; p.T604A; 11:46739349-46739349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.692G>A; p.G231E; 11:46725991-46725991	skin	malignant_melanoma	Substitution - Missense
c.1729C>T; p.P577S; 11:46739268-46739268	central_nervous_system; brain	glioma	Substitution - Missense
c.404G>A; p.R135H; 11:46723267-46723267	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.494C>T; p.T165M; 11:46723453-46723453	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.404G>A; p.R135H; 11:46723267-46723267	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.494C>T; p.T165M; 11:46723453-46723453	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.601G>T; p.G201C; 11:46725900-46725900	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.494C>T; p.T165M; 11:46723453-46723453	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.388C>A; p.Q130K; 11:46723251-46723251	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.593G>A; p.R198H; 11:46725892-46725892	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1291C>T; p.R431C; 11:46728156-46728156	stomach	adenocarcinoma	Substitution - Missense
c.1573G>A; p.V525M; 11:46729480-46729480	pancreas	carcinoma	Substitution - Missense
c.10G>A; p.V4I; 11:46719245-46719245	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.590C>T; p.P197L; 11:46725889-46725889	skin; acral	malignant_melanoma	Substitution - Missense
c.590C>T; p.P197L; 11:46725889-46725889	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.398G>T; p.R133M; 11:46723261-46723261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.423-7G>C; p.?; 11:46723375-46723375	stomach	carcinoma; adenocarcinoma	Unknown
c.423-7G>C; p.?; 11:46723375-46723375	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.778A>T; p.N260Y; 11:46726077-46726077	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1790A>G; p.D597G; 11:46739329-46739329	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.200A>T; p.Y67F; 11:46719822-46719822	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.22C>A; p.Q8K; 11:46719257-46719257	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1459G>A; p.E487K; 11:46728824-46728824	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.894G>C; p.E298D; 11:46726517-46726517	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.593G>T; p.R198L; 11:46725892-46725892	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1376T>A; p.L459Q; 11:46728741-46728741	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.472C>T; p.R158C; 11:46723431-46723431	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1390G>T; p.A464S; 11:46728755-46728755	breast	carcinoma	Substitution - Missense
c.4G>A; p.A2T; 11:46719239-46719239	skin	malignant_melanoma	Substitution - Missense
c.1671A>G; p.E557E; 11:46739064-46739064	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.330G>T; p.E110D; 11:46723193-46723193	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.650G>A; p.R217Q; 11:46725949-46725949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.257A>T; p.K86M; 11:46720539-46720539	thyroid	other; neoplasm	Substitution - Missense
c.1021C>T; p.L341L; 11:46726728-46726728	skin	malignant_melanoma	Substitution - coding silent
c.265G>A; p.A89T; 11:46720547-46720547	central_nervous_system; brain	glioma	Substitution - Missense
c.1536A>T; p.T512T; 11:46729443-46729443	breast	carcinoma	Substitution - coding silent
c.1477C>T; p.L493F; 11:46729384-46729384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.381T>C; p.I127I; 11:46723244-46723244	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.831C>T; p.A277A; 11:46726130-46726130	breast	carcinoma	Substitution - coding silent
c.831C>T; p.A277A; 11:46726130-46726130	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1307G>A; p.R436Q; 11:46728672-46728672	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>T; p.G267W; 11:46726098-46726098	prostate	carcinoma	Substitution - Missense
c.734delT; p.L245fs*135; 11:46726033-46726033	prostate	adenoma	Deletion - Frameshift
c.1682G>A; p.G561E; 11:46739075-46739075	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.941G>A; p.R314H; 11:46726564-46726564	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1443G>T; p.V481V; 11:46728808-46728808	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.808G>A; p.E270K; 11:46726107-46726107	skin	malignant_melanoma	Substitution - Missense
c.1080C>T; p.I360I; 11:46726787-46726787	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation