| Gene ID | 2147 |
| Symbol | F2 |
| Synonymous | PT|RPRGL2|THPH1 |
| Full name | coagulation factor II (thrombin) |
| Gene description | prepro-coagulation factor II|prothrombin|prothrombin B-chain|serine protease |
| Cytoband | 11p11 |
| Gene type | protein-coding |
| Synonymous | MIM:176930; HGNC:HGNC:3535; Ensembl:ENSG00000180210; HPRD:01488; Vega:OTTHUMG00000150344 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Formation of Fibrin Clot (Clotting Cascade);PID Reactome;500300 |
Pathway | Syndecan-4-mediated signaling events;PID Curated;200115 |
Pathway | thrombin signaling and protease-activated receptors;PID BioCarta;100082 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Common Pathway;PID Reactome;500303 |
Pathway | Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs);PID Reactome;500133 |
Pathway | Neuroactive ligand-receptor interaction;KEGG PATHWAY;hsa04080 |
Pathway | intrinsic prothrombin activation pathway;PID BioCarta;100122 |
Pathway | Intrinsic Pathway;PID Reactome;500302 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Thrombin signalling through proteinase activated receptors (PARs);PID Reactome;500961 |
Pathway | aspirin blocks signaling pathway involved in platelet activation;PID BioCarta;100030 |
Pathway | platelet amyloid precursor protein pathway;PID BioCarta;100072 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins;PID Reactome;500540 |
Pathway | Peptide ligand-binding receptors;PID Reactome;500405 |
Pathway | extrinsic prothrombin activation pathway;PID BioCarta;100168 |
Pathway | Complement and coagulation cascades;KEGG PATHWAY;hsa04610 |
Pathway | Blood coagulation;PANTHER;P00011 |
Pathway | Metabolism of proteins;Reactome;REACT:17015 |
Pathway | Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;PID Reactome;500542 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Gamma-carboxylation of protein precursors;PID Reactome;500541 |
Pathway | Removal of aminoterminal propeptides from gamma-carboxylated proteins;PID Reactome;500543 |
Pathway | fibrinolysis pathway;PID BioCarta;100164 |
Pathway | FOXA2 and FOXA3 transcription factor networks;PID Curated;200073 |
Pathway | transcriptional activation of dbpb from mrna;PID BioCarta;100190 |
Disease | Lupus erythematosus;FunDO |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | pregnancy loss, recurrent;GAD |
Disease | inflammatory bowel disease;GAD |
Disease | HEMATOLOGICAL;GAD |
Disease | Systemic scleroderma;FunDO |
Disease | Hyperprothrombinemia;OMIM |
Disease | fetal loss;GAD |
Disease | massive thrombosis;GAD |
Disease | Liver cancer;FunDO |
Disease | vascular disease;GAD |
Disease | Malignant glioma;FunDO |
Disease | thrombosis, arterial;GAD |
Disease | Neoplasm metastasis;FunDO |
Disease | antiphospholipid syndrome;GAD |
Disease | elevated plasma prothrombin levels and an increase;GAD |
Disease | Embryoma;FunDO |
Disease | stroke, ischemic;GAD |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | Thrombosis;GAD |
Disease | atherosclerosis, coronary;GAD |
Disease | IMMUNE;GAD |
Disease | Aseptic necrosis of bone;FunDO |
Disease | Pulmonary fibrosis;FunDO |
Disease | Hypoprothrombinemia;OMIM |
Disease | Liver disease;FunDO |
Disease | Systemic infection;FunDO |
Disease | Dental plaque;FunDO |
Disease | Cardiovascular disease;FunDO |
Disease | Early occlusion of coronary by-pass;GAD |
Disease | thromboembolism, venous;GAD |
Disease | Branch retinal vein occlusion;GAD |
Disease | Inherited thrombophilia;KEGG DISEASE;H00223 |
Disease | METABOLIC;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | Venous Thrombosis;GAD |
Disease | REPRODUCTION;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Stroke;GAD |
Disease | Spinal cord infarction and recurrent venous thrombosis;GAD |
Disease | cerebrovascular disease;GAD |
Disease | Hemorrhagic disorder;FunDO |
Disease | Endometriosis;FunDO |
Disease | Dysprothrombinemia;OMIM |
Disease | bleeding complications;GAD |
Disease | Behcet's Disease;GAD |
Disease | Hyperhomocysteinemia;FunDO |
Disease | Behcet syndrome;FunDO |
Disease | bilateral iliac vein thrombosis;GAD |
Disease | Enteritis;FunDO |
Disease | factor V Leiden;GAD |
Disease | hearing loss/deafness;GAD |
Disease | Nevus;FunDO |
Disease | polycystic ovary syndrome;GAD |
Disease | Venous Thromboembolism;GAD |
Disease | myocardial infarct;GAD |
Disease | Abortion;FunDO |
Disease | Thrombophilia;FunDO |
Sequence Information | |
|---|---|
Nucleotide Sequence | >2147 : length: 2018 GTCAGGACAGACAATTCCTCAGTGACCCAGGAGCTGACACACTATGGCGCACGTCCGAGGCTTGCAGCTGCCTGGCTGCCTGGCCCTGGCTGCCCTGTGTAGCCTTGTGCACAGCCAGCA TGTGTTCCTGGCTCCTCAGCAAGCACGGTCGCTGCTCCAGCGGGTCCGGCGAGCCAACACCTTCTTGGAGGAGGTGCGCAAGGGCAACCTGGAGCGAGAGTGCGTGGAGGAGACGTGCAG CTACGAGGAGGCCTTCGAGGCTCTGGAGTCCTCCACGGCTACGGATGTGTTCTGGGCCAAGTACACAGCTTGTGAGACAGCGAGGACGCCTCGAGATAAGCTTGCTGCATGTCTGGAAGG TAACTGTGCTGAGGGTCTGGGTACGAACTACCGAGGGCATGTGAACATCACCCGGTCAGGCATTGAGTGCCAGCTATGGAGGAGTCGCTACCCACATAAGCCTGAAATCAACTCCACTAC CCATCCTGGGGCCGACCTACAGGAGAATTTCTGCCGCAACCCCGACAGCAGCACCACGGGACCCTGGTGCTACACTACAGACCCCACCGTGAGGAGGCAGGAATGCAGCATCCCTGTCTG TGGCCAGGATCAAGTCACTGTAGCGATGACTCCACGCTCCGAAGGCTCCAGTGTGAATCTGTCACCTCCATTGGAGCAGTGTGTCCCTGATCGGGGGCAGCAGTACCAGGGGCGCCTGGC GGTGACCACACATGGGCTCCCCTGCCTGGCCTGGGCCAGCGCACAGGCCAAGGCCCTGAGCAAGCACCAGGACTTCAACTCAGCTGTGCAGCTGGTGGAGAACTTCTGCCGCAACCCAGA CGGGGATGAGGAGGGCGTGTGGTGCTATGTGGCCGGGAAGCCTGGCGACTTTGGGTACTGCGACCTCAACTATTGTGAGGAGGCCGTGGAGGAGGAGACAGGAGATGGGCTGGATGAGGA CTCAGACAGGGCCATCGAAGGGCGTACCGCCACCAGTGAGTACCAGACTTTCTTCAATCCGAGGACCTTTGGCTCGGGAGAGGCAGACTGTGGGCTGCGACCTCTGTTCGAGAAGAAGTC GCTGGAGGACAAAACCGAAAGAGAGCTCCTGGAATCCTACATCGACGGGCGCATTGTGGAGGGCTCGGATGCAGAGATCGGCATGTCACCTTGGCAGGTGATGCTTTTCCGGAAGAGTCC CCAGGAGCTGCTGTGTGGGGCCAGCCTCATCAGTGACCGCTGGGTCCTCACCGCCGCCCACTGCCTCCTGTACCCGCCCTGGGACAAGAACTTCACCGAGAATGACCTTCTGGTGCGCAT TGGCAAGCACTCCCGCACCAGGTACGAGCGAAACATTGAAAAGATATCCATGTTGGAAAAGATCTACATCCACCCCAGGTACAACTGGCGGGAGAACCTGGACCGGGACATTGCCCTGAT GAAGCTGAAGAAGCCTGTTGCCTTCAGTGACTACATTCACCCTGTGTGTCTGCCCGACAGGGAGACGGCAGCCAGCTTGCTCCAGGCTGGATACAAGGGGCGGGTGACAGGCTGGGGCAA CCTGAAGGAGACGTGGACAGCCAACGTTGGTAAGGGGCAGCCCAGTGTCCTGCAGGTGGTGAACCTGCCCATTGTGGAGCGGCCGGTCTGCAAGGACTCCACCCGGATCCGCATCACTGA CAACATGTTCTGTGCTGGTTACAAGCCTGATGAAGGGAAACGAGGGGATGCCTGTGAAGGTGACAGTGGGGGACCCTTTGTCATGAAGAGCCCCTTTAACAACCGCTGGTATCAAATGGG CATCGTCTCATGGGGTGAAGGCTGTGACCGGGATGGGAAATATGGCTTCTACACACATGTGTTCCGCCTGAAGAAGTGGATACAGAAGGTCATTGATCAGTTTGGAGAGTAGGGGGCCAC TCATATTCTGGGCTCCTGGAACCAATCCCGTGAAAGAATTATTTTTGTGTTTCTAAAACTATGGTTCCCAATAAAAGTGACTCTCAGCGAAAAAAAAA |
Protein Sequence | >2147 : length: 622 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWIQKVIDQFGE |