Cancer metastasis database

Annotation category 5

Gene information

Gene ID 1843
Symbol

DUSP1

Synonymous

CL100|HVH1|MKP-1|MKP1|PTPN10

Full name

dual specificity phosphatase 1

Gene description

MAP kinase phosphatase 1|dual specificity protein phosphatase 1|dual specificity protein phosphatase hVH1|mitogen-activated protein kinase phosphatase 1|protein-tyrosine phosphatase CL100|serine/threonine specific protein phosphatase

Cytoband

5q34

Gene type

protein-coding

Synonymous

MIM:600714; HGNC:HGNC:3064; Ensembl:ENSG00000120129; HPRD:02835; Vega:OTTHUMG00000130523

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.471G>A; p.A157A; 5:172770203-172770203

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.977T>C; p.M326T; 5:172768889-172768889

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.584T>C; p.L195P; 5:172769724-172769724

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.497C>A; p.T166N; 5:172770177-172770177

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.55delG; p.E19fs*131; 5:172770898-172770898

 oesophaguscarcinoma; adenocarcinomaDeletion - Frameshift

c.1036C>T; p.P346S; 5:172768830-172768830

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.971C>T; p.P324L; 5:172768895-172768895

 skinmalignant_melanomaSubstitution - Missense

c.973G>A; p.A325T; 5:172768893-172768893

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1059G>A; p.A353A; 5:172768807-172768807

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.856G>C; p.E286Q; 5:172769010-172769010

 breastcarcinoma; ER-PR-positive_carcinomaSubstitution - Missense

c.595G>A; p.G199S; 5:172769713-172769713

 breastcarcinomaSubstitution - Missense

c.1052A>G; p.N351S; 5:172768814-172768814

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.945G>A; p.P315P; 5:172768921-172768921

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.941C>G; p.A314G; 5:172768925-172768925

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.488C>T; p.S163F; 5:172770186-172770186

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.488C>T; p.S163F; 5:172770186-172770186

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.157C>G; p.R53G; 5:172770796-172770796

 pancreascarcinomaSubstitution - Missense

c.513+2T>C; p.?; 5:172770159-172770159

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.1074G>A; p.Q358Q; 5:172768792-172768792

 skinmalignant_melanomaSubstitution - coding silent

c.616G>A; p.V206I; 5:172769692-172769692

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1011C>T; p.T337T; 5:172768855-172768855

 breastcarcinomaSubstitution - coding silent

c.1023C>A; p.F341L; 5:172768843-172768843

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.547C>T; p.L183L; 5:172769761-172769761

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1065C>A; p.S355R; 5:172768801-172768801

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.419C>T; p.S140L; 5:172770255-172770255

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1056T>A; p.S352R; 5:172768810-172768810

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.904A>G; p.M302V; 5:172768962-172768962

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.166G>A; p.A56T; 5:172770787-172770787

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.116A>T; p.H39L; 5:172770837-172770837

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1027G>A; p.V343I; 5:172768839-172768839

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.984G>T; p.V328V; 5:172768882-172768882

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.494G>T; p.S165I; 5:172770180-172770180

 pancreascarcinomaSubstitution - Missense

c.854T>A; p.F285Y; 5:172769012-172769012

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.426C>T; p.P142P; 5:172770248-172770248

 skinmalignant_melanomaSubstitution - coding silent

c.991C>T; p.R331*; 5:172768875-172768875

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1061T>C; p.L354P; 5:172768805-172768805

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1050G>A; p.T350T; 5:172768816-172768816

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.979G>A; p.A327T; 5:172768887-172768887

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense