lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1728
Symbol	NQO1
Synonymous	DHQU\|DIA4\|DTD\|NMOR1\|NMORI\|QR1
Full name	NAD(P)H dehydrogenase, quinone 1
Gene description	DT-diaphorase\|NAD(P)H dehydrogenase [quinone] 1\|NAD(P)H:Quinone acceptor oxidoreductase type 1\|NAD(P)H:menadione oxidoreductase 1\|NAD(P)H:quinone oxidoreductase 1\|NAD(P)H:quinone oxireductase\|azoreductase\|diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
Cytoband	16q22.1
Gene type	protein-coding
Synonymous	MIM:125860; HGNC:HGNC:2874; Ensembl:ENSG00000181019; HPRD:00518; Vega:OTTHUMG00000137575

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.822A>G; p.K274K; 16:69710979-69710979	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.365T>A; p.I122K; 16:69715016-69715016	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.497A>C; p.N166T; 16:69713050-69713050	breast	carcinoma	Substitution - Missense
c.792C>G; p.I264M; 16:69711009-69711009	breast	carcinoma	Substitution - Missense
c.108_122del15; p.E36_S40delEVVES; 16:69718420-69718434	ovary	carcinoma; serous_carcinoma	Deletion - In frame
c.759C>T; p.G253G; 16:69711042-69711042	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.472C>A; p.L158M; 16:69713075-69713075	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.677G>A; p.S226N; 16:69711124-69711124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.245G>T; p.S82I; 16:69718181-69718181	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.38C>G; p.S13*; 16:69718504-69718504	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Nonsense
c.72G>A; p.E24E; 16:69718470-69718470	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.135G>A; p.M45I; 16:69718407-69718407	skin	malignant_melanoma	Substitution - Missense
c.69G>T; p.K23N; 16:69718473-69718473	skin	malignant_melanoma	Substitution - Missense
c.465G>A; p.M155I; 16:69713082-69713082	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.615G>A; p.L205L; 16:69711186-69711186	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.126C>A; p.L42L; 16:69718416-69718416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.283G>A; p.A95T; 16:69718143-69718143	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.817A>G; p.R273G; 16:69710984-69710984	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.205_206CC>TT; p.P69F; 16:69718220-69718221	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.718A>C; p.K240Q; 16:69711083-69711083	kidney	other; neoplasm	Substitution - Missense
c.484C>A; p.H162N; 16:69713063-69713063	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.177A>G; p.K59K; 16:69718249-69718249	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.133A>T; p.M45L; 16:69718409-69718409	liver	carcinoma	Substitution - Missense
c.133A>T; p.M45L; 16:69718409-69718409	liver	carcinoma	Substitution - Missense
c.200A>C; p.Q67P; 16:69718226-69718226	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.529C>G; p.L177V; 16:69711272-69711272	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.254T>C; p.I85T; 16:69718172-69718172	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.392C>T; p.A131V; 16:69714989-69714989	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.559C>T; p.P187S; 16:69711242-69711242	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.559C>T; p.P187S; 16:69711242-69711242	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.559C>T; p.P187S; 16:69711242-69711242	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.717G>A; p.M239I; 16:69711084-69711084	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.414C>T; p.F138F; 16:69714967-69714967	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.602G>A; p.R201Q; 16:69711199-69711199	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.602G>A; p.R201Q; 16:69711199-69711199	prostate	carcinoma	Substitution - Missense
c.519+10T>G; p.?; 16:69713018-69713018	kidney	other; neoplasm	Unknown
c.48G>A; p.T16T; 16:69718494-69718494	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.648G>A; p.W216*; 16:69711153-69711153	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.192G>A; p.A64A; 16:69718234-69718234	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.85G>A; p.A29T; 16:69718457-69718457	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.631C>T; p.R211C; 16:69711170-69711170	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.631C>T; p.R211C; 16:69711170-69711170	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.7+7_7+10delGCTG; p.?; 16:69726423-69726426	lung	carcinoma; adenocarcinoma	Unknown
c.690C>T; p.D230D; 16:69711111-69711111	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation