lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1655
Symbol	DDX5
Synonymous	G17P1\|HLR1\|HUMP68\|p68
Full name	DEAD (Asp-Glu-Ala-Asp) box helicase 5
Gene description	ATP-dependent RNA helicase DDX5\|DEAD (Asp-Glu-Ala-Asp) box polypeptide 5\|DEAD box protein 5\|DEAD box-5\|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)\|RNA helicase p68\|probable ATP-dependent RNA helicase DDX5
Cytoband	17q21
Gene type	protein-coding
Synonymous	MIM:180630; HGNC:HGNC:2746; Ensembl:ENSG00000108654; HPRD:01615; Vega:OTTHUMG00000178936

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1340C>T; p.P447L; 17:64500650-64500650	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.597_606del10; p.C200fs*26; 17:64503473-64503482	breast	carcinoma	Deletion - Frameshift
c.372A>G; p.G124G; 17:64504052-64504052	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.648A>C; p.R216S; 17:64503431-64503431	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.775G>A; p.E259K; 17:64503223-64503223	urinary_tract; bladder	carcinoma	Substitution - Missense
c.346G>A; p.E116K; 17:64504078-64504078	large_intestine; colon	adenoma	Substitution - Missense
c.1105A>G; p.M369V; 17:64502213-64502213	liver	carcinoma	Substitution - Missense
c.23G>A; p.R8Q; 17:64506097-64506097	urinary_tract; bladder	carcinoma	Substitution - Missense
c.32G>T; p.G11V; 17:64506088-64506088	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.291T>G; p.Y97*; 17:64504238-64504238	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1622C>G; p.T541S; 17:64500146-64500146	liver	carcinoma	Substitution - Missense
c.1622C>G; p.T541S; 17:64500146-64500146	liver	carcinoma	Substitution - Missense
c.1444C>T; p.R482C; 17:64500324-64500324	skin	malignant_melanoma	Substitution - Missense
c.243A>C; p.E81D; 17:64504286-64504286	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1444C>T; p.R482C; 17:64500324-64500324	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1364A>G; p.D455G; 17:64500626-64500626	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1267G>A; p.E423K; 17:64500723-64500723	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.586T>G; p.L196V; 17:64503493-64503493	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1035T>C; p.I345I; 17:64502498-64502498	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1035T>C; p.I345I; 17:64502498-64502498	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.721A>G; p.R241G; 17:64503277-64503277	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.548T>G; p.V183G; 17:64503531-64503531	breast	carcinoma	Substitution - Missense
c.1218T>C; p.D406D; 17:64500772-64500772	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1604A>G; p.Y535C; 17:64500164-64500164	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1604A>G; p.Y535C; 17:64500164-64500164	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1603T>C; p.Y535H; 17:64500165-64500165	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1603T>C; p.Y535H; 17:64500165-64500165	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1618T>C; p.Y540H; 17:64500150-64500150	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1381C>T; p.R461C; 17:64500609-64500609	skin	malignant_melanoma	Substitution - Missense
c.1358T>C; p.V453A; 17:64500632-64500632	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1363G>A; p.D455N; 17:64500627-64500627	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1668C>T; p.T556T; 17:64500100-64500100	thyroid	carcinoma	Substitution - coding silent
c.727A>G; p.T243A; 17:64503271-64503271	skin	malignant_melanoma	Substitution - Missense
c.727A>G; p.T243A; 17:64503271-64503271	skin	malignant_melanoma	Substitution - Missense
c.1480C>T; p.R494W; 17:64500288-64500288	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.1425C>T; p.V475V; 17:64500565-64500565	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1588delA; p.T530fs*59; 17:64500180-64500180	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1681G>T; p.G561C; 17:64500087-64500087	skin	malignant_melanoma	Substitution - Missense
c.898A>G; p.I300V; 17:64503011-64503011	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.713A>G; p.N238S; 17:64503285-64503285	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1737T>G; p.S579R; 17:64500031-64500031	skin	malignant_melanoma	Substitution - Missense
c.1490A>G; p.Y497C; 17:64500278-64500278	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1134A>C; p.Q378H; 17:64502184-64502184	central_nervous_system; brain	glioma	Substitution - Missense
c.917A>T; p.E306V; 17:64502992-64502992	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1810A>T; p.I604F; 17:64499958-64499958	stomach	adenocarcinoma	Substitution - Missense
c.1843T>C; p.*615Q; 17:64499925-64499925	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Nonstop extension
c.1620delC; p.Y540fs*1; 17:64500148-64500148	breast	carcinoma	Deletion - Frameshift
c.149A>T; p.E50V; 17:64504738-64504738	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1379T>G; p.L460R; 17:64500611-64500611	breast	carcinoma	Substitution - Missense
c.495C>T; p.G165G; 17:64503815-64503815	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.495C>T; p.G165G; 17:64503815-64503815	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.475C>T; p.Q159*; 17:64503835-64503835	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1809G>A; p.M603I; 17:64499959-64499959	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1244A>G; p.N415S; 17:64500746-64500746	lung	carcinoid-endocrine_tumour	Substitution - Missense
c.293A>G; p.E98G; 17:64504236-64504236	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.808A>C; p.R270R; 17:64503190-64503190	breast	carcinoma	Substitution - coding silent
c.1598G>C; p.G533A; 17:64500170-64500170	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1577T>G; p.F526C; 17:64500191-64500191	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.302T>C; p.F101S; 17:64504227-64504227	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1015G>T; p.E339*; 17:64502518-64502518	breast	carcinoma	Substitution - Nonsense
c.1716T>G; p.D572E; 17:64500052-64500052	kidney	other; neoplasm	Substitution - Missense
c.440_441+2delCTGT; p.?; 17:64503981-64503984	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Unknown
c.1787C>T; p.P596L; 17:64499981-64499981	skin	malignant_melanoma	Substitution - Missense
c.881T>G; p.L294R; 17:64503028-64503028	skin	malignant_melanoma	Substitution - Missense
c.244A>G; p.I82V; 17:64504285-64504285	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1477C>A; p.R493S; 17:64500291-64500291	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.288T>G; p.F96L; 17:64504241-64504241	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1597G>T; p.G533C; 17:64500171-64500171	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1593G>C; p.Q531H; 17:64500175-64500175	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1597G>T; p.G533C; 17:64500171-64500171	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.658A>G; p.I220V; 17:64503340-64503340	liver	carcinoma	Substitution - Missense
c.831G>A; p.M277I; 17:64503078-64503078	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1732G>A; p.G578R; 17:64500036-64500036	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1366_1381del16; p.L456fs*29; 17:64500609-64500624	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1099C>T; p.P367S; 17:64502219-64502219	central_nervous_system; brain	glioma	Substitution - Missense
c.422G>C; p.G141A; 17:64504002-64504002	breast	carcinoma	Substitution - Missense
c.1650G>A; p.V550V; 17:64500118-64500118	pancreas	carcinoma	Substitution - coding silent
c.440C>G; p.S147C; 17:64503984-64503984	liver	carcinoma	Substitution - Missense
c.430A>G; p.K144E; 17:64503994-64503994	skin	malignant_melanoma	Substitution - Missense
c.805A>G; p.I269V; 17:64503193-64503193	liver	carcinoma	Substitution - Missense
c.1643A>G; p.N548S; 17:64500125-64500125	oesophagus	carcinoma	Substitution - Missense
c.1643A>G; p.N548S; 17:64500125-64500125	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1256C>G; p.P419R; 17:64500734-64500734	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.793A>G; p.I265V; 17:64503205-64503205	stomach	adenocarcinoma	Substitution - Missense
c.1659T>C; p.G553G; 17:64500109-64500109	pancreas	carcinoma	Substitution - coding silent
c.1398A>G; p.A466A; 17:64500592-64500592	liver	carcinoma	Substitution - coding silent
c.1631G>A; p.S544N; 17:64500137-64500137	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1652C>G; p.S551C; 17:64500116-64500116	liver	carcinoma	Substitution - Missense
c.1242C>T; p.I414I; 17:64500748-64500748	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.860G>C; p.R287T; 17:64503049-64503049	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.87A>G; p.L29L; 17:64504800-64504800	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1563G>A; p.L521L; 17:64500205-64500205	pancreas	carcinoma	Substitution - coding silent
c.571T>G; p.C191G; 17:64503508-64503508	urinary_tract; bladder	carcinoma	Substitution - Missense
c.913C>T; p.L305F; 17:64502996-64502996	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1531A>G; p.R511G; 17:64500237-64500237	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1591C>G; p.Q531E; 17:64500177-64500177	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.211-1G>A; p.?; 17:64504319-64504319	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.190G>A; p.D64N; 17:64504697-64504697	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1028A>C; p.K343T; 17:64502505-64502505	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1597G>A; p.G533S; 17:64500171-64500171	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1723C>T; p.Q575*; 17:64500045-64500045	urinary_tract; bladder	carcinoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation