lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	154
Symbol	ADRB2
Synonymous	ADRB2R\|ADRBR\|B2AR\|BAR\|BETA2AR
Full name	adrenoceptor beta 2, surface
Gene description	adrenergic, beta-2-, receptor, surface\|adrenoceptor beta 2 surface\|beta-2 adrenergic receptor\|beta-2 adrenoceptor\|beta-2 adrenoreceptor\|catecholamine receptor
Cytoband	5q31-q32
Gene type	protein-coding
Synonymous	MIM:109690; HGNC:HGNC:286; HPRD:00187

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.197C>T; p.T66M; 5:148827028-148827028	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.353C>T; p.T118M; 5:148827184-148827184	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.354G>A; p.T118T; 5:148827185-148827185	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.254C>A; p.A85E; 5:148827085-148827085	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.105C>T; p.G35G; 5:148826936-148826936	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.785C>T; p.S262F; 5:148827616-148827616	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1188C>A; p.S396R; 5:148828019-148828019	urinary_tract; bladder	carcinoma	Substitution - Missense
c.864C>T; p.P288P; 5:148827695-148827695	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.88G>T; p.E30*; 5:148826919-148826919	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.615C>T; p.I205I; 5:148827446-148827446	skin	malignant_melanoma	Substitution - coding silent
c.1143C>T; p.L381L; 5:148827974-148827974	skin	malignant_melanoma	Substitution - coding silent
c.276C>A; p.A92A; 5:148827107-148827107	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.88G>A; p.E30K; 5:148826919-148826919	breast	carcinoma	Substitution - Missense
c.1183C>G; p.P395A; 5:148828014-148828014	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1016T>G; p.L339R; 5:148827847-148827847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.319G>A; p.E107K; 5:148827150-148827150	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.528C>T; p.A176A; 5:148827359-148827359	central_nervous_system; brain	glioma	Substitution - coding silent
c.471G>C; p.V157V; 5:148827302-148827302	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.471G>C; p.V157V; 5:148827302-148827302	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.471G>C; p.V157V; 5:148827302-148827302	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.905T>C; p.L302P; 5:148827736-148827736	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.471G>C; p.V157V; 5:148827302-148827302	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.381C>T; p.I127I; 5:148827212-148827212	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1102G>T; p.V368L; 5:148827933-148827933	skin	malignant_melanoma	Substitution - Missense
c.245T>C; p.M82T; 5:148827076-148827076	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.245T>C; p.M82T; 5:148827076-148827076	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.996C>T; p.F332F; 5:148827827-148827827	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.909C>T; p.I303I; 5:148827740-148827740	skin	malignant_melanoma	Substitution - coding silent
c.502C>T; p.P168S; 5:148827333-148827333	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1113G>A; p.E371E; 5:148827944-148827944	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.712G>A; p.G238S; 5:148827543-148827543	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.802G>T; p.E268*; 5:148827633-148827633	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.889G>A; p.V297M; 5:148827720-148827720	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.12C>T; p.P4P; 5:148826843-148826843	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1186A>G; p.S396G; 5:148828017-148828017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1145C>T; p.P382L; 5:148827976-148827976	pancreas	carcinoma	Substitution - Missense
c.46G>A; p.G16R; 5:148826877-148826877	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.89A>C; p.E30A; 5:148826920-148826920	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.46G>A; p.G16R; 5:148826877-148826877	thyroid	other; neoplasm	Substitution - Missense
c.46G>A; p.G16R; 5:148826877-148826877	thyroid	other; neoplasm	Substitution - Missense
c.1053G>C; p.G351G; 5:148827884-148827884	prostate	carcinoma	Substitution - coding silent
c.1053G>C; p.G351G; 5:148827884-148827884	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1123A>G; p.K375E; 5:148827954-148827954	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.508C>A; p.Q170K; 5:148827339-148827339	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.522C>T; p.Y174Y; 5:148827353-148827353	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.971T>C; p.L324P; 5:148827802-148827802	liver	carcinoma	Substitution - Missense
c.252G>A; p.L84L; 5:148827083-148827083	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.932T>G; p.L311R; 5:148827763-148827763	skin	malignant_melanoma	Substitution - Missense
c.116T>C; p.V39A; 5:148826947-148826947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.826G>C; p.G276R; 5:148827657-148827657	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.324T>G; p.F108L; 5:148827155-148827155	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.377_378ins10; p.Y132fs*21; 5:148827208-148827209	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.6G>A; p.G2G; 5:148826837-148826837	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.957T>G; p.S319S; 5:148827788-148827788	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.332C>T; p.S111F; 5:148827163-148827163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.520T>A; p.Y174N; 5:148827351-148827351	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1027C>T; p.R343C; 5:148827858-148827858	central_nervous_system; brain	glioma	Substitution - Missense
c.1027C>T; p.R343C; 5:148827858-148827858	pancreas	carcinoma	Substitution - Missense
c.1027C>T; p.R343C; 5:148827858-148827858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1027C>T; p.R343C; 5:148827858-148827858	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.627C>T; p.Y209Y; 5:148827458-148827458	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.549C>T; p.N183N; 5:148827380-148827380	prostate	carcinoma	Substitution - coding silent
c.1071C>T; p.N357N; 5:148827902-148827902	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.945C>T; p.G315G; 5:148827776-148827776	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1193A>G; p.N398S; 5:148828024-148828024	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.570C>A; p.C190*; 5:148827401-148827401	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.896A>C; p.Q299P; 5:148827727-148827727	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.866T>C; p.F289S; 5:148827697-148827697	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.188G>A; p.R63H; 5:148827019-148827019	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.188G>A; p.R63H; 5:148827019-148827019	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.783T>C; p.S261S; 5:148827614-148827614	skin	malignant_melanoma	Substitution - coding silent
c.298A>G; p.T100A; 5:148827129-148827129	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.298A>G; p.T100A; 5:148827129-148827129	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.349G>A; p.V117I; 5:148827180-148827180	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.745G>A; p.E249K; 5:148827576-148827576	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.709G>C; p.E237Q; 5:148827540-148827540	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1051delG; p.N352fs>62; 5:148827882-148827882	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.19G>A; p.G7S; 5:148826850-148826850	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.523C>A; p.R175R; 5:148827354-148827354	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.523C>A; p.R175R; 5:148827354-148827354	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.523C>A; p.R175R; 5:148827354-148827354	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.726C>T; p.V242V; 5:148827557-148827557	skin	malignant_melanoma	Substitution - coding silent
c.368C>T; p.T123I; 5:148827199-148827199	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.459C>T; p.I153I; 5:148827290-148827290	skin	malignant_melanoma	Substitution - coding silent
c.534C>A; p.H178Q; 5:148827365-148827365	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1028G>A; p.R343H; 5:148827859-148827859	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.887A>G; p.H296R; 5:148827718-148827718	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.887A>G; p.H296R; 5:148827718-148827718	liver	carcinoma	Substitution - Missense
c.965A>G; p.N322S; 5:148827796-148827796	liver	carcinoma	Substitution - Missense
c.965A>G; p.N322S; 5:148827796-148827796	liver	carcinoma	Substitution - Missense
c.874G>A; p.V292I; 5:148827705-148827705	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.894C>T; p.I298I; 5:148827725-148827725	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.79G>C; p.E27Q; 5:148826910-148826910	thyroid	other; neoplasm	Substitution - Missense
c.114C>T; p.I38I; 5:148826945-148826945	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.707C>A; p.S236Y; 5:148827538-148827538	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.183C>T; p.F61F; 5:148827014-148827014	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.315G>A; p.W105*; 5:148827146-148827146	breast	carcinoma	Substitution - Nonsense
c.794G>C; p.C265S; 5:148827625-148827625	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation