lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1524
Symbol	CX3CR1
Synonymous	CCRL1\|CMKBRL1\|CMKDR1\|GPR13\|GPRV28\|V28
Full name	chemokine (C-X3-C motif) receptor 1
Gene description	C-X3-C CKR-1\|CMK-BRL-1\|CMK-BRL1\|CX3C chemokine receptor 1\|G protein-coupled receptor 13\|G-protein coupled receptor 13\|beta chemokine receptor-like 1\|chemokine (C-C) receptor-like 1\|chemokine (C-X3-C) receptor 1\|fractalkine receptor
Cytoband	3p21.3
Gene type	protein-coding
Synonymous	MIM:601470; HGNC:HGNC:2558; Ensembl:ENSG00000168329; HPRD:03277; Vega:OTTHUMG00000156249

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.927G>A; p.G309G; 3:39265583-39265583	skin	malignant_melanoma	Substitution - coding silent
c.675G>T; p.K225N; 3:39265835-39265835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.639A>C; p.R213S; 3:39265871-39265871	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.199G>A; p.D67N; 3:39266311-39266311	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.840G>T; p.T280T; 3:39265670-39265670	stomach	adenocarcinoma	Substitution - coding silent
c.1038G>C; p.T346T; 3:39265472-39265472	liver	carcinoma	Substitution - coding silent
c.1038G>C; p.T346T; 3:39265472-39265472	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.28G>T; p.E10*; 3:39266482-39266482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.450C>T; p.S150S; 3:39266060-39266060	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.42C>G; p.Y14*; 3:39266468-39266468	liver	carcinoma	Substitution - Nonsense
c.42C>G; p.Y14*; 3:39266468-39266468	liver	carcinoma	Substitution - Nonsense
c.1052C>T; p.A351V; 3:39265458-39265458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.161T>C; p.F54S; 3:39266349-39266349	pancreas	carcinoma	Substitution - Missense
c.1052C>T; p.A351V; 3:39265458-39265458	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.553G>T; p.E185*; 3:39265957-39265957	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.73G>A; p.D25N; 3:39266437-39266437	skin	malignant_melanoma	Substitution - Missense
c.143G>A; p.G48E; 3:39266367-39266367	skin	malignant_melanoma	Substitution - Missense
c.248C>T; p.T83I; 3:39266262-39266262	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1034A>G; p.H345R; 3:39265476-39265476	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.212T>C; p.L71P; 3:39266298-39266298	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.651G>A; p.T217T; 3:39265859-39265859	liver	carcinoma	Substitution - coding silent
c.659C>T; p.S220F; 3:39265851-39265851	skin	malignant_melanoma	Substitution - Missense
c.651G>A; p.T217T; 3:39265859-39265859	liver	carcinoma	Substitution - coding silent
c.787C>T; p.P263S; 3:39265723-39265723	skin	malignant_melanoma	Substitution - Missense
c.37G>A; p.E13K; 3:39266473-39266473	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.180G>A; p.K60K; 3:39266330-39266330	skin	malignant_melanoma	Substitution - coding silent
c.497T>C; p.M166T; 3:39266013-39266013	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.510G>C; p.Q170H; 3:39266000-39266000	urinary_tract; bladder	carcinoma	Substitution - Missense
c.210C>T; p.L70L; 3:39266300-39266300	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.839C>T; p.T280M; 3:39265671-39265671	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.376G>T; p.D126Y; 3:39266134-39266134	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.54T>C; p.A18A; 3:39266456-39266456	prostate	carcinoma	Substitution - coding silent
c.929A>T; p.K310I; 3:39265581-39265581	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.99C>T; p.F33F; 3:39266411-39266411	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.312C>A; p.F104L; 3:39266198-39266198	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.334G>A; p.G112S; 3:39266176-39266176	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1034A>T; p.H345L; 3:39265476-39265476	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.835G>A; p.E279K; 3:39265675-39265675	urinary_tract; bladder	carcinoma	Substitution - Missense
c.457G>A; p.V153I; 3:39266053-39266053	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.650C>T; p.T217M; 3:39265860-39265860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.650C>T; p.T217M; 3:39265860-39265860	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.764C>T; p.T255M; 3:39265746-39265746	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.650C>T; p.T217M; 3:39265860-39265860	pancreas	carcinoma	Substitution - Missense
c.650C>T; p.T217M; 3:39265860-39265860	pancreas	carcinoma	Substitution - Missense
c.600C>T; p.F200F; 3:39265910-39265910	skin	malignant_melanoma	Substitution - coding silent
c.750G>A; p.M250I; 3:39265760-39265760	skin	malignant_melanoma	Substitution - Missense
c.689T>A; p.I230N; 3:39265821-39265821	skin	malignant_melanoma	Substitution - Missense
c.393C>T; p.I131I; 3:39266117-39266117	skin	malignant_melanoma	Substitution - coding silent
c.393C>T; p.I131I; 3:39266117-39266117	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.472_473delAT; p.I158fs*16; 3:39266037-39266038	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.570C>T; p.L190L; 3:39265940-39265940	skin	malignant_melanoma	Substitution - coding silent
c.840G>A; p.T280T; 3:39265670-39265670	skin	malignant_melanoma	Substitution - coding silent
c.835G>C; p.E279Q; 3:39265675-39265675	urinary_tract; bladder	carcinoma	Substitution - Missense
c.758T>A; p.L253Q; 3:39265752-39265752	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.835G>C; p.E279Q; 3:39265675-39265675	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.253C>T; p.P85S; 3:39266257-39266257	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.723C>T; p.F241F; 3:39265787-39265787	skin	malignant_melanoma	Substitution - coding silent
c.43G>A; p.D15N; 3:39266467-39266467	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.43G>A; p.D15N; 3:39266467-39266467	skin	malignant_melanoma	Substitution - Missense
c.43G>A; p.D15N; 3:39266467-39266467	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.43G>A; p.D15N; 3:39266467-39266467	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.43G>A; p.D15N; 3:39266467-39266467	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.927G>C; p.G309G; 3:39265583-39265583	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.403G>A; p.A135T; 3:39266107-39266107	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.136C>A; p.L46M; 3:39266374-39266374	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.344G>A; p.G115E; 3:39266166-39266166	skin	malignant_melanoma	Substitution - Missense
c.876C>G; p.I292M; 3:39265634-39265634	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.651G>T; p.T217T; 3:39265859-39265859	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.176G>A; p.S59N; 3:39266334-39266334	skin	malignant_melanoma	Substitution - Missense
c.714C>T; p.I238I; 3:39265796-39265796	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.714C>T; p.I238I; 3:39265796-39265796	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.714C>T; p.I238I; 3:39265796-39265796	skin	malignant_melanoma	Substitution - coding silent
c.714C>T; p.I238I; 3:39265796-39265796	skin	malignant_melanoma	Substitution - coding silent
c.714C>T; p.I238I; 3:39265796-39265796	skin	malignant_melanoma	Substitution - coding silent
c.714C>T; p.I238I; 3:39265796-39265796	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.596G>C; p.G199A; 3:39265914-39265914	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.183G>A; p.K61K; 3:39266327-39266327	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.756C>T; p.F252F; 3:39265754-39265754	skin	malignant_melanoma	Substitution - coding silent
c.486A>T; p.A162A; 3:39266024-39266024	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.10T>G; p.F4V; 3:39266500-39266500	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.78C>A; p.I26I; 3:39266432-39266432	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.330C>T; p.F110F; 3:39266180-39266180	skin	malignant_melanoma	Substitution - coding silent
c.171C>T; p.T57T; 3:39266339-39266339	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.601C>T; p.L201L; 3:39265909-39265909	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1A>G; p.M1V; 3:39266509-39266509	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.42C>T; p.Y14Y; 3:39266468-39266468	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.42C>T; p.Y14Y; 3:39266468-39266468	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.390C>A; p.A130A; 3:39266120-39266120	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.295A>T; p.N99Y; 3:39266215-39266215	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1004_1005delGA; p.G335fs*13; 3:39265505-39265506	breast	carcinoma	Deletion - Frameshift
c.554A>C; p.E185A; 3:39265956-39265956	skin	malignant_melanoma	Substitution - Missense
c.925G>T; p.G309W; 3:39265585-39265585	skin	malignant_melanoma	Substitution - Missense
c.258C>T; p.F86F; 3:39266252-39266252	skin	malignant_melanoma	Substitution - coding silent
c.452T>C; p.L151P; 3:39266058-39266058	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.327C>T; p.F109F; 3:39266183-39266183	skin	malignant_melanoma	Substitution - coding silent
c.481G>A; p.A161T; 3:39266029-39266029	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.199G>C; p.D67H; 3:39266311-39266311	breast	carcinoma	Substitution - Missense
c.999G>A; p.R333R; 3:39265511-39265511	skin	malignant_melanoma	Substitution - coding silent
c.736C>T; p.P246S; 3:39265774-39265774	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.831G>A; p.V277V; 3:39265679-39265679	skin	malignant_melanoma	Substitution - coding silent
c.553G>A; p.E185K; 3:39265957-39265957	skin	malignant_melanoma	Substitution - Missense
c.455G>T; p.G152V; 3:39266055-39266055	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.273G>A; p.L91L; 3:39266237-39266237	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.869C>T; p.P290L; 3:39265641-39265641	skin	malignant_melanoma	Substitution - Missense
c.451C>G; p.L151V; 3:39266059-39266059	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.869C>T; p.P290L; 3:39265641-39265641	skin	malignant_melanoma	Substitution - Missense
c.953G>A; p.R318H; 3:39265557-39265557	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.244G>A; p.A82T; 3:39266266-39266266	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.517A>G; p.N173D; 3:39265993-39265993	skin	malignant_melanoma	Substitution - Missense
c.78C>T; p.I26I; 3:39266432-39266432	skin	malignant_melanoma	Substitution - coding silent
c.414G>A; p.M138I; 3:39266096-39266096	skin	malignant_melanoma	Substitution - Missense
c.354C>T; p.F118F; 3:39266156-39266156	skin	malignant_melanoma	Substitution - coding silent
c.696G>A; p.L232L; 3:39265814-39265814	skin	malignant_melanoma	Substitution - coding silent
c.813G>A; p.L271L; 3:39265697-39265697	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.608C>T; p.P203L; 3:39265902-39265902	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.813G>A; p.L271L; 3:39265697-39265697	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.137T>C; p.L46P; 3:39266373-39266373	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.974C>T; p.S325F; 3:39265536-39265536	skin	malignant_melanoma	Substitution - Missense
c.565G>A; p.V189M; 3:39265945-39265945	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.565G>A; p.V189M; 3:39265945-39265945	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.419A>G; p.N140S; 3:39266091-39266091	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.841G>T; p.V281F; 3:39265669-39265669	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.565G>A; p.V189M; 3:39265945-39265945	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation