lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1452
Symbol	CSNK1A1
Synonymous	CK1\|CK1a\|CKIa\|HEL-S-77p\|HLCDGP1\|PRO2975
Full name	casein kinase 1, alpha 1
Gene description	CKI-alpha\|casein kinase I isoform alpha\|clock regulator kinase\|down-regulated in lung cancer\|epididymis secretory sperm binding protein Li 77p
Cytoband	5q32
Gene type	protein-coding
Synonymous	MIM:600505; HGNC:HGNC:2451; Ensembl:ENSG00000113712; HPRD:02739; Vega:OTTHUMG00000163463

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.183C>A; p.S61R; 5:149550122-149550122	urinary_tract; bladder	carcinoma	Substitution - Missense
c.292G>A; p.E98K; 5:149525110-149525110	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.844C>T; p.R282C; 5:149507040-149507040	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.72G>C; p.G24G; 5:149550893-149550893	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.618A>G; p.S206S; 5:149511851-149511851	skin	malignant_melanoma	Substitution - coding silent
c.968C>A; p.T323K; 5:149505485-149505485	meninges	meningioma; secretory	Substitution - Missense
c.418G>C; p.D140H; 5:149520328-149520328	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.845G>A; p.R282H; 5:149507039-149507039	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.121G>T; p.E41*; 5:149550844-149550844	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.293A>G; p.E98G; 5:149525109-149525109	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.820T>C; p.Y274H; 5:149507064-149507064	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.406G>T; p.D136Y; 5:149520340-149520340	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.287G>T; p.S96I; 5:149525115-149525115	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.419A>C; p.D140A; 5:149520327-149520327	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	Substitution - Missense
c.419A>C; p.D140A; 5:149520327-149520327	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; mast_cell_neoplasm	Substitution - Missense
c.419A>C; p.D140A; 5:149520327-149520327	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.419A>C; p.D140A; 5:149520327-149520327	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.633G>A; p.L211L; 5:149511836-149511836	liver	carcinoma	Substitution - coding silent
c.250G>A; p.D84N; 5:149525152-149525152	urinary_tract; bladder	carcinoma	Substitution - Missense
c.456+2T>C; p.?; 5:149520288-149520288	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.28G>T; p.E10*; 5:149550937-149550937	breast	carcinoma	Substitution - Nonsense
c.28G>T; p.E10*; 5:149550937-149550937	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.810A>C; p.E270D; 5:149507074-149507074	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.407A>G; p.D136G; 5:149520339-149520339	liver	carcinoma	Substitution - Missense
c.140T>C; p.L47P; 5:149550165-149550165	skin	malignant_melanoma	Substitution - Missense
c.260T>C; p.V87A; 5:149525142-149525142	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.231-2A>T; p.?; 5:149525173-149525173	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.601C>T; p.R201*; 5:149511868-149511868	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.601C>T; p.R201*; 5:149511868-149511868	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.62G>T; p.R21L; 5:149550903-149550903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.947delG; p.G316fs*19; 5:149505506-149505506	bone; humerus	chondrosarcoma	Deletion - Frameshift
c.846C>T; p.R282R; 5:149507038-149507038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.216C>T; p.G72G; 5:149550089-149550089	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.780_781insTTA; p.L260_N261insL; 5:149507103-149507104	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Insertion - In frame
c.554C>T; p.A185V; 5:149513112-149513112	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.554C>T; p.A185V; 5:149513112-149513112	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.554C>T; p.A185V; 5:149513112-149513112	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.554C>T; p.A185V; 5:149513112-149513112	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.436A>G; p.I146V; 5:149520310-149520310	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.436A>G; p.I146V; 5:149520310-149520310	liver	carcinoma	Substitution - Missense
c.121G>A; p.E41K; 5:149550844-149550844	urinary_tract; bladder	carcinoma	Substitution - Missense
c.725C>G; p.S242C; 5:149509904-149509904	breast	carcinoma	Substitution - Missense
c.958C>G; p.Q320E; 5:149505495-149505495	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.930C>G; p.A310A; 5:149505523-149505523	breast	carcinoma	Substitution - coding silent
c.623G>A; p.G208E; 5:149511846-149511846	skin	malignant_melanoma	Substitution - Missense
c.739G>T; p.V247F; 5:149509890-149509890	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.222C>A; p.P74P; 5:149550083-149550083	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.178G>A; p.E60K; 5:149550127-149550127	breast	carcinoma	Substitution - Missense
c.138G>A; p.K46K; 5:149550167-149550167	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.875A>G; p.Y292C; 5:149505578-149505578	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.157A>T; p.R53W; 5:149550148-149550148	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.236A>G; p.Y79C; 5:149525166-149525166	liver	carcinoma	Substitution - Missense
c.236A>G; p.Y79C; 5:149525166-149525166	liver	carcinoma	Substitution - Missense
c.88G>T; p.D30Y; 5:149550877-149550877	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.88G>T; p.D30Y; 5:149550877-149550877	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.561T>A; p.Y187*; 5:149513105-149513105	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Nonsense
c.770C>T; p.A257V; 5:149507114-149507114	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.770C>T; p.A257V; 5:149507114-149507114	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.670C>T; p.L224L; 5:149511799-149511799	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation