lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10401
Symbol	PIAS3
Synonymous	ZMIZ5
Full name	protein inhibitor of activated STAT, 3
Gene description	E3 SUMO-protein ligase PIAS3\|protein inhibitor of activated STAT protein 3\|zinc finger, MIZ-type containing 5
Cytoband	1q21
Gene type	protein-coding
Synonymous	MIM:605987; HGNC:HGNC:16861; Ensembl:ENSG00000131788; HPRD:09068; Vega:OTTHUMG00000013750

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.663C>T; p.P221P; 1:145855742-145855742	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.820G>A; p.V274M; 1:145854548-145854548	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1533C>T; p.L511L; 1:145850502-145850502	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.949G>A; p.A317T; 1:145853848-145853848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.44G>A; p.R15Q; 1:145856987-145856987	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1702C>G; p.H568D; 1:145849631-145849631	central_nervous_system; brain	glioma	Substitution - Missense
c.631C>T; p.L211F; 1:145855774-145855774	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.285C>A; p.P95P; 1:145856746-145856746	skin	malignant_melanoma	Substitution - coding silent
c.442+1G>A; p.?; 1:145856588-145856588	prostate	carcinoma	Unknown
c.726C>T; p.I242I; 1:145854824-145854824	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1716A>G; p.P572P; 1:145849617-145849617	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1759G>A; p.A587T; 1:145849574-145849574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1292G>T; p.S431I; 1:145850927-145850927	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1259C>T; p.P420L; 1:145851040-145851040	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1494T>A; p.P498P; 1:145850541-145850541	thyroid	carcinoma	Substitution - coding silent
c.1071G>A; p.M357I; 1:145853578-145853578	skin	malignant_melanoma	Substitution - Missense
c.588C>G; p.L196L; 1:145855817-145855817	oesophagus	carcinoma	Substitution - coding silent
c.1598C>T; p.S533L; 1:145850254-145850254	skin	malignant_melanoma	Substitution - Missense
c.281C>T; p.A94V; 1:145856750-145856750	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1693A>T; p.T565S; 1:145849640-145849640	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.813C>T; p.S271S; 1:145854555-145854555	skin	malignant_melanoma	Substitution - coding silent
c.649G>T; p.G217W; 1:145855756-145855756	skin	malignant_melanoma	Substitution - Missense
c.864A>G; p.K288K; 1:145854504-145854504	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1657C>A; p.Q553K; 1:145849676-145849676	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1657C>A; p.Q553K; 1:145849676-145849676	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1387C>T; p.P463S; 1:145850832-145850832	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.436A>C; p.T146P; 1:145856595-145856595	breast	carcinoma	Substitution - Missense
c.1703A>C; p.H568P; 1:145849630-145849630	breast	carcinoma	Substitution - Missense
c.305C>T; p.A102V; 1:145856726-145856726	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.522A>G; p.T174T; 1:145856352-145856352	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.191G>A; p.R64H; 1:145856840-145856840	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1622A>T; p.H541L; 1:145849711-145849711	liver	carcinoma	Substitution - Missense
c.1658A>C; p.Q553P; 1:145849675-145849675	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.496C>T; p.P166S; 1:145856378-145856378	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.818C>G; p.S273C; 1:145854550-145854550	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.545C>T; p.A182V; 1:145856101-145856101	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.435C>T; p.T145T; 1:145856596-145856596	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.270T>A; p.P90P; 1:145856761-145856761	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.438C>T; p.T146T; 1:145856593-145856593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1710G>C; p.L570L; 1:145849623-145849623	ovary	other; neoplasm	Substitution - coding silent
c.849A>G; p.G283G; 1:145854519-145854519	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1506G>A; p.T502T; 1:145850529-145850529	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.391C>T; p.P131S; 1:145856640-145856640	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.257C>T; p.P86L; 1:145856774-145856774	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1775G>A; p.R592H; 1:145849558-145849558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1471C>T; p.P491S; 1:145850564-145850564	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1047C>T; p.F349F; 1:145853602-145853602	pancreas	carcinoma	Substitution - coding silent
c.289C>T; p.P97S; 1:145856742-145856742	oesophagus	carcinoma	Substitution - Missense
c.642G>A; p.K214K; 1:145855763-145855763	prostate	adenoma	Substitution - coding silent
c.1253_1254insC; p.P421fs*22; 1:145851045-145851046	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1378G>A; p.D460N; 1:145850841-145850841	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.883C>T; p.R295W; 1:145854485-145854485	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.918G>T; p.E306D; 1:145853879-145853879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.404A>G; p.Y135C; 1:145856627-145856627	thyroid	carcinoma	Substitution - Missense
c.918G>T; p.E306D; 1:145853879-145853879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.44G>T; p.R15L; 1:145856987-145856987	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.499C>T; p.Q167*; 1:145856375-145856375	skin	malignant_melanoma	Substitution - Nonsense
c.1872C>T; p.I624I; 1:145849461-145849461	skin	malignant_melanoma	Substitution - coding silent
c.1032C>A; p.A344A; 1:145853617-145853617	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1649T>G; p.L550R; 1:145849684-145849684	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.697G>A; p.A233T; 1:145854853-145854853	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1692G>A; p.G564G; 1:145849641-145849641	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1546T>A; p.Y516N; 1:145850489-145850489	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1529G>A; p.S510N; 1:145850506-145850506	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1136T>C; p.I379T; 1:145853513-145853513	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1843C>T; p.P615S; 1:145849490-145849490	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.426C>G; p.I142M; 1:145856605-145856605	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.524C>G; p.S175C; 1:145856350-145856350	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.524C>G; p.S175C; 1:145856350-145856350	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.524C>G; p.S175C; 1:145856350-145856350	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.524C>G; p.S175C; 1:145856350-145856350	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1728G>A; p.T576T; 1:145849605-145849605	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.606C>A; p.P202P; 1:145855799-145855799	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1466A>T; p.H489L; 1:145850569-145850569	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1862G>A; p.R621Q; 1:145849471-145849471	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1844C>T; p.P615L; 1:145849489-145849489	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1302delG; p.G436fs*15; 1:145850917-145850917	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.458A>C; p.Q153P; 1:145856416-145856416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.187C>T; p.R63*; 1:145856844-145856844	large_intestine; caecum	adenoma	Substitution - Nonsense
c.668C>T; p.P223L; 1:145855737-145855737	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.964C>T; p.R322W; 1:145853833-145853833	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.375T>C; p.P125P; 1:145856656-145856656	pancreas	carcinoma	Substitution - coding silent
c.375T>C; p.P125P; 1:145856656-145856656	pancreas	carcinoma	Substitution - coding silent
c.318G>T; p.L106L; 1:145856713-145856713	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.566A>T; p.Q189L; 1:145856080-145856080	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1606C>A; p.Q536K; 1:145850246-145850246	urinary_tract; bladder	carcinoma	Substitution - Missense
c.213G>A; p.G71G; 1:145856818-145856818	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.946_947GT>AC; p.V316T; 1:145853850-145853851	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1054G>A; p.A352T; 1:145853595-145853595	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1260G>A; p.P420P; 1:145851039-145851039	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.310G>T; p.G104C; 1:145856721-145856721	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1381C>G; p.L461V; 1:145850838-145850838	liver	carcinoma	Substitution - Missense
c.1381C>G; p.L461V; 1:145850838-145850838	liver	carcinoma	Substitution - Missense
c.427C>T; p.R143W; 1:145856604-145856604	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.783T>C; p.N261N; 1:145854767-145854767	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.660delC; p.L222fs*56; 1:145855745-145855745	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1774C>A; p.R592S; 1:145849559-145849559	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1145+7C>T; p.?; 1:145853497-145853497	liver	carcinoma	Unknown
c.82C>T; p.R28W; 1:145856949-145856949	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1483C>T; p.L495L; 1:145850552-145850552	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1798delG; p.A602fs*2; 1:145849535-145849535	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.428G>A; p.R143Q; 1:145856603-145856603	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.165G>A; p.M55I; 1:145856866-145856866	skin	malignant_melanoma	Substitution - Missense
c.936T>C; p.P312P; 1:145853861-145853861	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.798C>T; p.F266F; 1:145854752-145854752	skin	malignant_melanoma	Substitution - coding silent
c.798C>T; p.F266F; 1:145854752-145854752	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.724A>G; p.I242V; 1:145854826-145854826	prostate	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation