Cancer metastasis database

Annotation category 5

Gene information

Gene ID 10140
Symbol

TOB1

Synonymous

APRO6|PIG49|TOB|TROB|TROB1

Full name

transducer of ERBB2, 1

Gene description

proliferation-inducing gene 49|protein Tob1|transducer of erbB-2 1

Cytoband

17q21

Gene type

protein-coding

Synonymous

MIM:605523; HGNC:HGNC:11979; Ensembl:ENSG00000141232; HPRD:09273; Vega:OTTHUMG00000162277

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.561C>G; p.F187L; 17:50863457-50863457

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.313G>A; p.E105K; 17:50863705-50863705

livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.313G>A; p.E105K; 17:50863705-50863705

livercarcinomaSubstitution - Missense

c.208C>T; p.Q70*; 17:50863810-50863810

lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.793T>A; p.S265T; 17:50863225-50863225

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.614C>T; p.S205F; 17:50863404-50863404

urinary_tract; bladdercarcinomaSubstitution - Missense

c.317A>G; p.K106R; 17:50863701-50863701

kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.829C>T; p.P277S; 17:50863189-50863189

skinmalignant_melanomaSubstitution - Missense

c.406G>A; p.A136T; 17:50863612-50863612

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.535_536delAC; p.T179fs*16; 17:50863482-50863483

lungcarcinoma; adenocarcinomaDeletion - Frameshift

c.769_770insCACCAC; p.P256_Q257insPP; 17:50863248-50863249

bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourInsertion - In frame

c.67A>T; p.R23*; 17:50863951-50863951

thyroidcarcinoma; medullary_carcinomaSubstitution - Nonsense

c.411G>T; p.Q137H; 17:50863607-50863607

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.95T>A; p.L32H; 17:50863923-50863923

livercarcinomaSubstitution - Missense

c.95T>A; p.L32H; 17:50863923-50863923

livercarcinomaSubstitution - Missense

c.904C>T; p.Q302*; 17:50863114-50863114

skinmalignant_melanomaSubstitution - Nonsense

c.645C>G; p.D215E; 17:50863373-50863373

kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.423C>T; p.P141P; 17:50863595-50863595

lung; middle_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.91G>T; p.E31*; 17:50863927-50863927

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.93A>G; p.E31E; 17:50863925-50863925

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.743_744insA; p.P249fs*22; 17:50863274-50863275

large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.743_744insA; p.P249fs*22; 17:50863274-50863275

large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.756A>G; p.P252P; 17:50863262-50863262

urinary_tract; bladdercarcinomaSubstitution - coding silent

c.63_124del62; p.R22fs*5; 17:50863894-50863955

livercarcinoma; hepatocellular_carcinomaDeletion - Frameshift

c.72T>C; p.R24R; 17:50863946-50863946

large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.72T>C; p.R24R; 17:50863946-50863946

large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.287C>G; p.P96R; 17:50863731-50863731

livercarcinomaSubstitution - Missense

c.287C>G; p.P96R; 17:50863731-50863731

livercarcinomaSubstitution - Missense

c.143A>G; p.K48R; 17:50863875-50863875

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.143A>G; p.K48R; 17:50863875-50863875

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.144G>T; p.K48N; 17:50863874-50863874

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.144G>T; p.K48N; 17:50863874-50863874

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.645C>T; p.D215D; 17:50863373-50863373

breastcarcinomaSubstitution - coding silent

c.329_330insT; p.K110fs*7; 17:50863688-50863689

ovarycarcinoma; serous_carcinomaInsertion - Frameshift

c.247C>T; p.R83C; 17:50863771-50863771

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.32T>G; p.F11C; 17:50863986-50863986

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.32T>G; p.F11C; 17:50863986-50863986

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.901C>T; p.L301F; 17:50863117-50863117

urinary_tract; bladdercarcinomaSubstitution - Missense

c.612T>A; p.T204T; 17:50863406-50863406

oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.752C>T; p.P251L; 17:50863266-50863266

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.307A>T; p.I103F; 17:50863711-50863711

kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.349A>G; p.N117D; 17:50863669-50863669

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.349A>G; p.N117D; 17:50863669-50863669

pancreascarcinomaSubstitution - Missense

c.142A>G; p.K48E; 17:50863876-50863876

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.142A>G; p.K48E; 17:50863876-50863876

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.276_277insAGTGTT; p.V92_W93insSV; 17:50863741-50863742

breastcarcinomaInsertion - In frame

c.425T>C; p.I142T; 17:50863593-50863593

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.568A>G; p.T190A; 17:50863450-50863450

skin; extremitymalignant_melanomaSubstitution - Missense

c.789A>C; p.K263N; 17:50863229-50863229

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.136C>G; p.P46A; 17:50863882-50863882

breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.136C>T; p.P46S; 17:50863882-50863882

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.340G>A; p.V114M; 17:50863678-50863678

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.823_826delATTT; p.I275fs*47; 17:50863192-50863195

endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.299C>A; p.S100Y; 17:50863719-50863719

breastcarcinomaSubstitution - Missense

c.1000T>C; p.Y334H; 17:50863018-50863018

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.887_888insCC; p.N297fs*27; 17:50863130-50863131

salivary_glandcarcinoma; adenoid_cystic_carcinomaInsertion - Frameshift

c.283G>A; p.D95N; 17:50863735-50863735

urinary_tract; bladdercarcinomaSubstitution - Missense

c.440C>T; p.S147L; 17:50863578-50863578

breastcarcinomaSubstitution - Missense

c.256C>T; p.L86L; 17:50863762-50863762

urinary_tract; bladdercarcinomaSubstitution - coding silent

c.508C>T; p.R170W; 17:50863510-50863510

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense