| Gene ID | 4214 |
| Symbol | MAP3K1 |
| Synonymous | MAPKKK1|MEKK|MEKK 1|MEKK1|SRXY6 |
| Full name | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
| Gene description | MAP/ERK kinase kinase 1|MAPK/ERK kinase kinase 1|MEK kinase 1|mitogen-activated protein kinase kinase kinase 1 |
| Cytoband | 5q11.2 |
| Gene type | protein-coding |
| Synonymous | MIM:600982; HGNC:HGNC:6848; Ensembl:ENSG00000095015; Vega:OTTHUMG00000059486 |
Pathways and Diseases | Detail |
|---|---|
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | rac1 cell motility signaling pathway;PID BioCarta;100056 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | human cytomegalovirus and map kinase pathways;PID BioCarta;100149 |
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Pathway | tnfr2 signaling pathway;PID BioCarta;100014 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | nf-kb signaling pathway;PID BioCarta;100097 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | map kinase inactivation of smrt corepressor;PID BioCarta;100032 |
Pathway | signal transduction through il1r;PID BioCarta;100132 |
Pathway | fas signaling pathway (cd95);PID BioCarta;100167 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | p38 mapk signaling pathway;PID BioCarta;100085 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | cd40l signaling pathway;PID BioCarta;100213 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | MyD88 cascade;PID Reactome;500445 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | role of mal in rho-mediated activation of srf;PID BioCarta;100114 |
Pathway | p38 MAPK signaling pathway;PID Curated;200014 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | tnf/stress related signaling;PID BioCarta;100026 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | ceramide signaling pathway;PID BioCarta;100206 |
Pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling;PID Curated;200152 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Disease | Breast cancer;NHGRI |
Disease | breast cancer;GAD |
Disease | CANCER;GAD |
Disease | Cancer;FunDO |
Disease | Diabetes mellitus;FunDO |
Sequence Information | |
|---|---|
Nucleotide Sequence | >4214 : length: 7522 CACCAGAAACCCAAGTTGGAACTAATTCTTTCTTTCGGAAGGTGCAACTCCCCTCCCGCGAGCTCCGCGGTGCCGGGCCGAGATTGCCGAGAGGAAGCGGCGCAGCGCTGCCGCCAAGGC TCCTCCTGTCGCCGGTGCGGCCGGGACTACCTGGCGGCGCGGCGCGTGCAGCGCGCAGAGTCCCGGGAGCCCACGCCTCCGCCTCCGCCCCCGCCCCCTCCGCCTCCCAGTCCACCTCGC CCGCCCGCCCTCTCGCCCGGCGGAGAGCACAGCCCACTCCCTCCCACCTGCGGCCGCCGGGCCGCCCTCCACCCACACCTCTGCCGCAGGCCGGACCCAGTGCGCCCGCCCGTCGGTCAG TCCAGGCCAGGCGCCCGGCGGGCCGCGCTCACGCAGTTGGCGCAGGAGGCCTTACGCTGGCGGCGCAGTGCCCGCCCCCTGCGCTCTCCCCGCCCCCTCCCTCCCTCGCAGGGGCCGAGC GAATGTAGCCCGCGAGAGAAAATGGCGGCGGCGGCGGGGAATCGCGCCTCGTCGTCGGGATTCCCGGGCGCCAGGGCTACGAGCCCTGAGGCAGGCGGCGGCGGAGGAGCCCTCAAGGCG AGCAGCGCGCCCGCGGCTGCCGCGGGACTGCTGCGGGAGGCGGGCAGCGGGGGCCGCGAGCGGGCGGACTGGCGGCGGCGGCAGCTGCGCAAAGTGCGGAGTGTGGAGCTGGACCAGCTG CCTGAGCAGCCGCTCTTCCTTGCCGCCTCACCGCCGGCCTCCTCGACTTCCCCGTCGCCGGAGCCCGCGGACGCAGCGGGGAGTGGGACCGGCTTCCAGCCTGTGGCGGTGCCGCCGCCC CACGGAGCCGCGAGCCGCGGCGGCGCCCACCTTACCGAGTCGGTGGCGGCGCCGGACAGCGGCGCCTCGAGTCCCGCAGCGGCCGAGCCCGGGGAGAAGCGGGCGCCCGCCGCCGAGCCG TCTCCTGCAGCGGCCCCCGCCGGTCGTGAGATGGAGAATAAAGAAACTCTCAAAGGGTTGCACAAGATGGATGATCGTCCAGAGGAACGAATGATCAGGGAGAAACTGAAGGCAACCTGT ATGCCAGCCTGGAAGCACGAATGGTTGGAAAGGAGAAATAGGCGAGGGCCTGTGGTGGTAAAACCAATCCCAGTTAAAGGAGATGGATCTGAAATGAATCACTTAGCAGCTGAGTCTCCA GGAGAGGTCCAGGCAAGTGCGGCTTCACCAGCTTCCAAAGGCCGACGCAGTCCTTCTCCTGGCAACTCCCCATCAGGTCGCACAGTGAAATCAGAATCTCCAGGAGTAAGGAGAAAAAGA GTTTCCCCAGTGCCTTTTCAGAGTGGCAGAATCACACCACCCCGAAGAGCCCCTTCACCAGATGGCTTCTCACCATATAGCCCTGAGGAAACAAACCGCCGTGTTAACAAAGTGATGCGG GCCAGACTGTACTTACTGCAGCAGATAGGGCCTAACTCTTTCCTGATTGGAGGAGACAGCCCAGACAATAAATACCGGGTGTTTATTGGGCCTCAGAACTGCAGCTGTGCACGTGGAACA TTCTGTATTCATCTGCTATTTGTGATGCTCCGGGTGTTTCAACTAGAACCTTCAGACCCAATGTTATGGAGAAAAACTTTAAAGAATTTTGAGGTTGAGAGTTTGTTCCAGAAATATCAC AGTAGGCGTAGCTCAAGGATCAAAGCTCCATCTCGTAACACCATCCAGAAGTTTGTTTCACGCATGTCAAATTCTCATACATTGTCATCATCTAGTACTTCTACGTCTAGTTCAGAAAAC AGCATAAAGGATGAAGAGGAACAGATGTGTCCTATTTGCTTGTTGGGCATGCTTGATGAAGAAAGTCTTACAGTGTGTGAAGACGGCTGCAGGAACAAGCTGCACCACCACTGCATGTCA ATTTGGGCAGAAGAGTGTAGAAGAAATAGAGAACCTTTAATATGTCCCCTTTGTAGATCTAAGTGGAGATCTCATGATTTCTACAGCCACGAGTTGTCAAGTCCTGTGGATTCCCCTTCT TCCCTCAGAGCTGCACAGCAGCAAACCGTACAGCAGCAGCCTTTGGCTGGATCACGAAGGAATCAAGAGAGCAATTTTAACCTTACTCATTATGGAACTCAGCAAATCCCTCCTGCTTAC AAAGATTTAGCTGAGCCATGGATTCAGGTGTTTGGAATGGAACTCGTTGGCTGCTTATTTTCTAGAAACTGGAATGTGAGAGAGATGGCCCTCAGGCGTCTTTCCCATGATGTCAGTGGG GCCCTGCTGTTGGCAAATGGGGAGAGCACTGGAAATTCTGGGGGCAGCAGTGGAAGCAGCCCGAGTGGGGGAGCCACCAGTGGGTCTTCCCAGACCAGTATCTCAGGAGATGTGGTGGAG GCATGCTGCAGCGTTCTGTCAATGGTCTGTGCTGACCCTGTCTACAAAGTGTACGTTGCTGCTTTAAAAACATTGAGAGCCATGCTGGTATATACTCCTTGCCACAGTTTAGCGGAAAGA ATCAAACTTCAGAGACTTCTCCAGCCAGTTGTAGACACCATCCTAGTCAAATGTGCAGATGCCAATAGCCGCACAAGTCAGCTGTCCATATCAACACTGTTGGAACTGTGCAAAGGCCAA GCAGGAGAGTTGGCAGTTGGCAGAGAAATACTAAAAGCTGGATCCATTGGTATTGGTGGTGTTGATTATGTCTTAAATTGTATTCTTGGAAACCAAACTGAATCAAACAATTGGCAAGAA CTTCTTGGCCGCCTTTGTCTTATAGATAGACTGTTGTTGGAATTTCCTGCTGAATTTTATCCTCATATTGTCAGTACTGATGTTTCACAAGCTGAGCCTGTTGAAATCAGGTATAAGAAG CTGCTGTCCCTCTTAACCTTTGCTTTGCAGTCCATTGATAATTCCCACTCAATGGTTGGCAAACTTTCCAGAAGGATCTACTTGAGTTCTGCAAGAATGGTTACTACAGTACCCCATGTG TTTTCAAAACTGTTAGAAATGCTGAGTGTTTCCAGTTCCACTCACTTCACCAGGATGCGTCGCCGTTTGATGGCTATTGCAGATGAGGTGGAAATTGCCGAAGCCATCCAGTTGGGCGTA GAAGACACTTTGGATGGTCAACAGGACAGCTTCTTGCAGGCATCTGTTCCCAACAACTATCTGGAAACCACAGAGAACAGTTCCCCTGAGTGCACAGTCCATTTAGAGAAAACTGGAAAA GGATTATGTGCTACAAAATTGAGTGCCAGTTCAGAGGACATTTCTGAGAGACTGGCCAGCATTTCAGTAGGACCTTCTAGTTCAACAACAACAACAACAACAACAACAGAGCAACCAAAG CCAATGGTTCAAACAAAAGGCAGACCCCACAGTCAGTGTTTGAACTCCTCTCCTTTATCTCATCATTCCCAATTAATGTTTCCAGCCTTGTCAACCCCTTCTTCTTCTACCCCATCTGTA CCAGCTGGCACTGCAACAGATGTCTCTAAGCATAGACTTCAGGGATTCATTCCCTGCAGAATACCTTCTGCATCTCCTCAAACACAGCGCAAGTTTTCTCTACAATTCCACAGAAACTGT CCTGAAAACAAAGACTCAGATAAACTTTCCCCAGTCTTTACTCAGTCAAGACCCTTGCCCTCCAGTAACATACACAGGCCAAAGCCATCTAGACCTACCCCAGGTAATACAAGTAAACAG GGAGATCCCTCAAAAAATAGCATGACACTTGATCTGAACAGTAGTTCCAAATGTGATGACAGCTTTGGCTGTAGCAGCAATAGTAGTAATGCTGTTATACCCAGTGACGAGACAGTGTTC ACCCCAGTAGAGGAGAAATGCAGATTAGATGTCAATACAGAGCTCAACTCCAGTATTGAGGACCTTCTTGAAGCATCTATGCCTTCAAGTGATACAACAGTAACTTTTAAGTCAGAAGTT GCTGTCCTGTCTCCTGAAAAGGCTGAAAATGATGATACCTACAAAGATGATGTGAATCATAATCAAAAGTGCAAAGAGAAGATGGAAGCTGAAGAAGAAGAAGCTTTAGCAATTGCCATG GCAATGTCAGCGTCTCAGGATGCCCTCCCCATAGTTCCTCAGCTGCAGGTTGAAAATGGAGAAGATATCATCATTATTCAACAGGATACACCAGAGACTCTACCAGGACATACCAAAGCA AAACAACCGTATAGAGAAGACACTGAATGGCTGAAAGGTCAACAGATAGGCCTTGGAGCATTTTCTTCTTGTTATCAGGCTCAAGATGTGGGAACTGGAACTTTAATGGCTGTTAAACAG GTGACTTATGTCAGAAACACATCTTCTGAGCAAGAAGAAGTAGTAGAAGCACTAAGAGAAGAGATAAGAATGATGAGCCATCTGAATCATCCAAACATCATTAGGATGTTGGGAGCCACG TGTGAGAAGAGCAATTACAATCTCTTCATTGAATGGATGGCAGGGGGATCGGTGGCTCATTTGCTGAGTAAATATGGAGCCTTCAAAGAATCAGTAGTTATTAACTACACTGAACAGTTA CTCCGTGGCCTTTCGTATCTCCATGAAAACCAAATCATTCACAGAGATGTCAAAGGTGCCAATTTGCTAATTGACAGCACTGGTCAGAGACTAAGAATTGCAGATTTTGGAGCTGCAGCC AGGTTGGCATCAAAAGGAACTGGTGCAGGAGAGTTTCAGGGACAATTACTGGGGACAATTGCATTTATGGCACCTGAGGTACTAAGAGGTCAACAGTATGGAAGGAGCTGTGATGTATGG AGTGTTGGCTGTGCTATTATAGAAATGGCTTGTGCAAAACCACCATGGAATGCAGAAAAACACTCCAATCATCTTGCTTTGATATTTAAGATTGCTAGTGCAACTACTGCTCCATCGATC CCTTCACATTTGTCTCCTGGTTTACGAGATGTGGCTCTTCGTTGTTTAGAACTTCAACCTCAGGACAGACCTCCATCAAGAGAGCTACTGAAGCATCCAGTCTTTCGTACTACATGGTAG CCAATTATGCAGATCAACTACAGTAGAAACAGGATGCTCAACAAGAGAAAAAAAACTTGTGGGGAACCACATTGATATTCTACTGGCCATGATGCCACTGAACAGCTATGAACGAGGCCA GTGGGGAACCCTTACCTAAGTATGTGATTGACAAATCATGATCTGTACCTAAGCTCAGTATGCAAAAGCCCAAACTAGTGCAGAAACTGTAAACTGTGCCTTTCAAAGAACTGGCCCTAG GTGAACAGGAAAACAATGAAGTTTGCATGACTAAATTGCAGAAGCATAATTTTATTTTTTTGGAGCACTTTTTCAGCAATATTAGCGGCTGAGGGGCTCAGGATCTATTTTAATATTTCA ATTATTCTTCCATTTCATATAGTGATCACAAGCAGGGGGTTCTGCAATTCCGTTCAAATTTTTTGTCACTGGCTATAAAATCAGTATCTGCCTCTTTTAGGTCAGAGTATGCTATGAGTA GCAATACATACATATATTTTTAAAAGTTGATACTTCTTTATGACCCACAGTTGACCTTTATTTTCTTAAATACCAGGGCAGTTGTGGCTCATTGTGCATTTTACTGTTGGCCCATTCATT TCGTTTTTGGAAATTATGGTTTTGTATTTTCATGTTTATTTACATTCATTTTTGTTTATTCAGGGAAAGCTGATCTTTTTTTCAAACCAGAAAAAAAAAATGAACTAGATATGAAGTAGA GTTCATTAAATATCTTGCTATTGTCAGAGTTTTTAAAATATAGACTTAATTTTGTTTTTTTAAATTGGAATACAATAAAGTACTACCTACATTTGAGTCAGTCACCACTCTTATTGTGCA GGTTAAGTACAAGTTAACTAAAAATAAACTGTCCTCTCTGGTGCAACTCACAACCAAGATCAAGATTACCTTAAAATTTATTTGAATTTTTTAGATGTTTTGGTTGTCAAACTGTAGGAA ACTTCACAACATTTAAGTCTTACTCTGTATGTAACAATCCATCATTCACCTTCACTACTGGTAGTAACATAGAGCTGCCATTTTCCTTTTACCATGCATCATCTCTTTACAGTAGGCCTG GCAGATCATTTTTTAAAAAGATTATTCAACTACCAATCAGTAATGTTTTTAAACAGTACATTTGCTTTGAACTTGGAAAATGTGTTCAGAAAGAAAAATGGAATTGAATTTCATTTATAC ACTAATTCCTTGGATTTTGCACAGTTACCTAACGGTTTTAGTCTGGAGTTAAATTCAGATGCATGGAATCCTGAAGGAAAATGGTAGCTTTTTAATCTTTTTGTGTGTGTGTGAGTCTTT TAAATCAAGTACTGATTAACTATTAAGTACAACTTTGAGATTTTAGTTTTAACTCTTCAGAAGCCAGTGTGAAATAGAATTGGTTATTCTCAAAGACTCAGGATAAACTAAATAAGCTAT ATATAGAGTACATTTAAAATGTACAACACAAATTGGAAATAAAATAAGTTACAAGATAAGTTTACAGGGATATATTGCTTACAATTTTTAAAAGGCAGTTTGTTTTTTATGTGAATATGT TTCTTAGTGAAATTTTACATTCCTTTGTTTTGGAAGATTGGCGATATTTGAAGAGTTAAAAATAGTACAGAAATGTGAAGTTTGGTATCTCTAAATGTGTTGTACTTGACTTTCTTTTTT ATTTTGTTTTTTTTTTTTTTTGACTACTTAGAATTTTCACAATTCTAATAAGATTGTTTCCAAGTCTCTCATGTGCAAGCTTTAAAGGATGCACTCTTGCCATTTTATGTACTGGAAGAT CATTGGTCAGATGAATACTGTGTCTGACAAAAATGTAAACTGTATAAACTGAGGAACCTCAGCTAATCAGTATTACTTTGTAGATCACCATGCCCACCACATTTCAAACTCAAACTATCT GTAGATTTCAAAATCCATTGTGTTTGAGTTTGTTTGCAGTTCCCTCAGCTTGCTGGTAATTGTGGTGTTTTGTTTTTTGTTTTGTTTTCAATGCAAATGTGATGTAATATTCTTATTTTC TTTGGATCAAAGCTGGACTGGAAATTGTATCGTGTAATTATTTTTGTGTTCTTAATGTTATTTGGTACTCAAGTTGTAAATAACGTCTACTACTGTTTATTCCAGTTTCTACTACCTCAG GTGTCCTATAGATTTTTCTTCTACCAAAGTTCACTTTCACAATGAAATTATATTTGCTGTGTGACTATGATTCCTAAGATTTCCAGGGCTTAAGGGCTAACTTCTATTAGCACCTTACTG TGTAAGCAAATGTTACAAAAAAAAAAAAAAAAAATCTCTGGGTTAAGAAAATTTGGCTTAAATGTATCCTTTGTTATTTTAAATATATTGAGATATTTTAATTAAAATTTTTACCCCATT GAACCGATTTTATAGTATTTGTACCTATTTTGGTGTTTTTGTCTTTATAGTAAATAAAAGTTTTTGAACAAAAAAAAAAAAA |
Protein Sequence | >4214 : length: 1512 MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRRQLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW |