| Gene ID | 3551 |
| Symbol | IKBKB |
| Synonymous | IKK-beta|IKK2|IKKB|IMD15|NFKBIKB |
| Full name | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| Gene description | I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta |
| Cytoband | 8p11.2 |
| Gene type | protein-coding |
| Synonymous | MIM:603258; HGNC:HGNC:5960; Ensembl:ENSG00000104365; HPRD:04462; Vega:OTTHUMG00000164092 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Atypical NF-kappaB pathway;PID Curated;200017 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | p75(NTR)-mediated signaling;PID Curated;200103 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Endogenous TLR signaling;PID Curated;200177 |
Pathway | Viral dsRNA:TLR3:TRIF Complex Activates RIP1;PID Reactome;500448 |
Pathway | p75NTR recruits signalling complexes;PID Reactome;500614 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | IL1-mediated signaling events;PID Curated;200075 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | human TAK1 activates NFkB by phosphorylation and activation of IKKs complex;PID Reactome;500450 |
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | NOD-like receptor signaling pathway;KEGG PATHWAY;hsa04621 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | mTOR signaling pathway;PID Curated;200080 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Interleukin-1 signaling;PID Reactome;500490 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | Cytosolic DNA-sensing pathway;KEGG PATHWAY;hsa04623 |
Pathway | nf-kb signaling pathway;PID BioCarta;100097 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | signal transduction through il1r;PID BioCarta;100132 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Downstream TCR signaling;PID Reactome;500482 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Canonical NF-kappaB pathway;PID Curated;200026 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | tnf/stress related signaling;PID BioCarta;100026 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Type II diabetes mellitus;KEGG PATHWAY;hsa04930 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Prostate cancer;FunDO |
Disease | Infectious lung disease;FunDO |
Disease | Leukemia;FunDO |
Disease | Tuberous sclerosis;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Yersinia infection;FunDO |
Disease | Breast cancer;FunDO |
Disease | Liver cancer;FunDO |
Sequence Information | |
|---|---|
Nucleotide Sequence | >3551 : length: 4187 GTGACGTCAGAGCAGGAAGTGTTTGAGGAAGTCGCGCCGCGCTGCCCGCGTTAAGATTCCCGCATTTTAATGTTTTCAGGGGGGTGTCATAGCCCCGGGTTTGGCCGCCCCAGCCCCGCC TTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCCTGCCGACAGAGTTAGCACGACATCAGTATGAGCTGGTCACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAA GAGCGCCTTGGGACAGGGGGATTTGGAAATGTCATCCGATGGCACAATCAGGAAACAGGTGAGCAGATTGCCATCAAGCAGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGG TGCCTGGAGATCCAGATCATGAGAAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGACCTGCCCCTGCTGGCCATGGAGTAC TGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGTGCCATCCTCACCTTGCTGAGTGACATTGGTAAATCCCAGTCCCGGAATTCAGGC CGTGTCCTTCAGGGAGAGTGTGGTGCCCCTCCTCTGCGCTTAGATACCTTCATGAAAACAGAATCATCCATCGGGATCTAAAGCCAGAAAACATCGTCCTGCAGCAAGGAGAACAGAGGT TAATACACAAAATTATTGACCTAGGATATGCCAAGGAGCTGGATCAGGGCAGTCTTTGCACATCATTCGTGGGGACCCTGCAGTACCTGGCCCCAGAGCTACTGGAGCAGCAGAAGTACA CAGTGACCGTCGACTACTGGAGCTTCGGCACCCTGGCCTTTGAGTGCATCACGGGCTTCCGGCCCTTCCTCCCCAACTGGCAGCCCGTGCAGTGGCATTCAAAAGTGCGGCAGAAGAGTG AGGTGGACATTGTTGTTAGCGAAGACTTGAATGGAACGGTGAAGTTTTCAAGCTCTTTACCCTACCCCAATAATCTTAACAGTGTCCTGGCTGAGCGACTGGAGAAGTGGCTGCAACTGA TGCTGATGTGGCACCCCCGACAGAGGGGCACGGATCCCACGTATGGGCCCAATGGCTGCTTCAAGGCCCTGGATGACATCTTAAACTTAAAGCTGGTTCATATCTTGAACATGGTCACGG GCACCATCCACACCTACCCTGTGACAGAGGATGAGAGTCTGCAGAGCTTGAAGGCCAGAATCCAACAGGACACGGGCATCCCAGAGGAGGACCAGGAGCTGCTGCAGGAAGCGGGCCTGG CGTTGATCCCCGATAAGCCTGCCACTCAGTGTATTTCAGACGGCAAGTTAAATGAGGGCCACACATTGGACATGGATCTTGTTTTTCTCTTTGACAACAGTAAAATCACCTATGAGACTC AGATCTCCCCACGGCCCCAACCTGAAAGTGTCAGCTGTATCCTTCAAGAGCCCAAGAGGAATCTCGCCTTCTTCCAGCTGAGGAAGGTGTGGGGCCAGGTCTGGCACAGCATCCAGACCC TGAAGGAAGATTGCAACCGGCTGCAGCAGGGACAGCGAGCCGCCATGATGAATCTCCTCCGAAACAACAGCTGCCTCTCCAAAATGAAGAATTCCATGGCTTCCATGTCTCAGCAGCTCA AGGCCAAGTTGGATTTCTTCAAAACCAGCATCCAGATTGACCTGGAGAAGTACAGCGAGCAAACCGAGTTTGGGATCACATCAGATAAACTGCTGCTGGCCTGGAGGGAAATGGAGCAGG CTGTGGAGCTCTGTGGGCGGGAGAACGAAGTGAAACTCCTGGTAGAACGGATGATGGCTCTGCAGACCGACATTGTGGACTTACAGAGGAGCCCCATGGGCCGGAAGCAGGGGGGAACGC TGGACGACCTAGAGGAGCAAGCAAGGGAGCTGTACAGGAGACTAAGGGAAAAACCTCGAGACCAGCGAACTGAGGGTGACAGTCAGGAAATGGTACGGCTGCTGCTTCAGGCAATTCAGA GCTTCGAGAAGAAAGTGCGAGTGATCTATACGCAGCTCAGTAAAACTGTGGTTTGCAAGCAGAAGGCGCTGGAACTGTTGCCCAAGGTGGAAGAGGTGGTGAGCTTAATGAATGAGGATG AGAAGACTGTTGTCCGGCTGCAGGAGAAGCGGCAGAAGGAGCTCTGGAATCTCCTGAAGATTGCTTGTAGCAAGGTCCGTGGTCCTGTCAGTGGAAGCCCGGATAGCATGAATGCCTCTC GACTTAGCCAGCCTGGGCAGCTGATGTCTCAGCCCTCCACGGCCTCCAACAGCTTACCTGAGCCAGCCAAGAAGAGTGAAGAACTGGTGGCTGAAGCACATAACCTCTGCACCCTGCTAG AAAATGCCATACAGGACACTGTGAGGGAACAAGACCAGAGTTTCACGGCCCTAGACTGGAGCTGGTTACAGACGGAAGAAGAAGAGCACAGCTGCCTGGAGCAGGCCTCATGATGTGGGG GGACTCGACCCCCTGACATGGGGCAGCCCATAGCAGGCCTTGTGCAGTGGGGGGACTCGACCCCCTGACATGGGGCTGCCTGGAGCAGGCCGCGTGACGTGGGGCTGCCTGGCCGCGGCT CTCACATGGTGGTTCCTGCTGCACTGATGGCCCAGGGGTCTCTGGTATCCAGATGGAGCTCTCGCTTCCTCAGCAGCTGTGACTTTCACCCAGGACCCAGGACGCAGCCCTCCGTGGGCA CTGCCGGCGCCTTGTCTGCACACTGGAGGTCCTCCATTACAGAGGCCCAGCGCACATCGCTGGCCCCACAAACGTTCAGGGGTACAGCCATGGCAGCTCCTTCCTCTGCCGTGAGAAAAG TGCTTGGAGTACGGTTTGCCACACACGTGACTGGACAGTGTCCAATTCAAATCTTTCAGGGCAGAGTCCGAGCAGCGCTTGGTGACAGCCTGTCCTCTCCTGCTCTCCAAAGGCCCTGCT CCCTGTCCTCTCTCACTTTACAGCTTGTGTTTCTTCTGGATTCAGCTTCTCCTAAACAGACAGTTTAATTATAGTTGCGGCCTGGCCCCATCCTCACTTCCTCTTTTTATTTCACTGCTG CTAAAATTGTGTTTTTACCTACTACTTTGGTGGTTGTCCTCTTTTCGGCAAAGTTGGAGCGAGTGCCAAGCTCTCCATCTGTGGTCCTTTCTGCCAAGAGCGACTCATAGTAACCAGGAT GGGAGAGCAGCTGCCTTATTCTGAATCCCAAAAATTACTTGGGGGTGATTGTCACAGAGGAGGGACAGAAAGGGTATCTGCTGACCACCAGCCTGCCTACCCATGCCCATGTCTCCATTC CTGCTCAAGCGTGTGTGCTGGGCCGGGGAGTCCCTGTCTCTCACAGCATCTAGCAGTATTATTAAATGGATTCATTTTAAAAATAGCTCCTATATTTTGTAACATGTCTCAAACACTCAT ACTGGGTTCCACAATCCACTGTTAGAATACCTATGGTTAGGGCTTCTGAACTAAAATAATGGAAAATTTTAACAATTTGTATAGTGCCTGGATCATTACTAGTGCCATAACCCTGCTTCT TCAACATTTCACAGAACTTCTCTTTTATATAAAGGCAAGAGCACAAAATGAGTTCAGATGATCACAAACAGGTGAGTTTTGTTGGAGAAGAAAGTTGGAGTAGGAGACTTTCACAAGTGG TTTCCATGGAGATAGAATGAAGCATTCTGTGGTCAAGTAAGTTTAGGGAGCTATTCATGTTTCACTTGCTTTGTGGAGATTCACACTATGCACTGGGAAAGTATCTGAAAAGTCTTATAA TAAAGAAACAGGCTTAACTTTGTGTAAGAACACTGTTTATCAATGTCATTTGGCTATAGAAACATTTTCTCCTGCTGATTGTGTGTGTGAAACATGTATTAACATTCCAATGAACTAGCA TTTAATAAAGCACAATTTTGGAAACCCTGGTAAATGACAGTGGGAAATAACACCCGAAAGGCAAGGACGGGCAGATTGGGGAGGGAAAGGATGTTGGGCTAAGGGCTGTGAGCTTATGTT ACAGGCAACTGAGCCACTGAAGAATTTTGACGAAGAAAATGCCAACCAAAGCAGTCATTTTAAAAGTTTATGGCTGTTCAGTTACAGGACAAGTTGTGAAAAGAAAG |
Protein Sequence | >3551 : length: 805 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE NAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIEEKMEMQSGIILNLSVCLFACLFVTGSLSLTQAGVQWHDLGSLQPPLPGFK |