| Gene ID | 23327 |
| Symbol | NEDD4L |
| Synonymous | NEDD4-2|NEDD4.2|RSP5|hNEDD4-2 |
| Full name | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
| Gene description | E3 ubiquitin-protein ligase NEDD4-like|ubiquitin-protein ligase Rsp5 |
| Cytoband | 18q21.31 |
| Gene type | protein-coding |
| Synonymous | MIM:606384; HGNC:HGNC:7728; Ensembl:ENSG00000049759; HPRD:05903; Vega:OTTHUMG00000179875 |
Pathways and Diseases | Detail |
|---|---|
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | Aldosterone-regulated sodium reabsorption;KEGG PATHWAY;hsa04960 |
Disease | Hypotension, Orthostatic;GAD |
Disease | RENAL;GAD |
Disease | hypertension;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | renin activity salt sensitivity;GAD |
Sequence Information | |
|---|---|
Nucleotide Sequence | >23327 : length: 8760 GGGGCCCGGACGGCGCTAGCGAGGAGGCGGGCGAGCCGGGTCCCCGGGAGCGCAGAGGAGGCTCGGAGGGGGGCGGAGAGCGGCGGGGCGGGAGGGAGGCGCGGGTCGCGGGGAGGGAAA GCCCGGCCGGGTCTGCGCCGCCGCCGCGCGCAGTGAGAGGCGCCGGGGCTGCCGCCCGGTGCTCGGCGCGCTCTCGGGAGCCGCCCGCCCGCTGGTCCCGCAGCCTTCCGGGAGGAAGCG GTGCCGGCAGCGTCCAGGGCGCGCTCTCGGGCACCCTCACCTGCCGGCGCCCGGCCGCTTACCCGGCAGGGCGTGCGCAGGGTAGGGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGA GAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCAGACCCCGCGCGGGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAG AGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGCTTCTGCTCCATTGCTGTTGAACTTTTTTTTGGTCGTGACATCAGAAAAA TAACCAAGTGTGAGTCTGATAATAGCAATGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACC CAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCC TTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCT ATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTC CTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGG AGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGC CTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAA GCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCC ATCTACCACCGCCCAGTGCCCCAGCTGGGAGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGGG AAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACA GTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAG ACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCC GGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTC CTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAGCAGCCAGGTGTTATGTGGAGAAAATGATACCAGAGAATCAGTGCCTTCATACGATAGCAAAATTA CTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATA TCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAAT CAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACGGACAACTACACCCTTC AGATCAACCCTAATTCAGGCCTCTGTAATGAGGATCATTTGTCCTACTTCACTTTTATTGGAAGAGTTGCTGGTCTGGCCGTATTTCATGGGAAGCTCTTAGATGGTTTCTTCATTAGAC CATTTTACAAGATGATGTTGGGAAAGCAGATAACCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAATGGATCCTGGAGAATGACCCTACTGAGCTGGACCTCA TGTTCTGCATAGACGAAGAAAACTTTGGACAGACATATCAAGTGGATTTGAAGCCCAATGGGTCAGAAATAATGGTCACAAATGAAAACAAAAGGGAATATATCGACTTAGTCATCCAGT GGAGATTTGTGAACAGGGTCCAGAAGCAGATGAACGCCTTCTTGGAGGGATTCACAGAACTACTTCCTATTGATTTGATTAAAATTTTTGATGAAAATGAGCTGGAGTTGCTCATGTGCG GCCTCGGTGATGTGGATGTGAATGACTGGAGACAGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAGTGGTTCTGGAAGGCTGTGCTACTCATGGACGCCGAAA AGCGTATCCGGTTACTGCAGTTTGTCACAGGGACATCGCGAGTACCTATGAATGGATTTGCCGAACTTTATGGTTCCAATGGTCCTCAGCTGTTTACAATAGAGCAATGGGGCAGTCCTG AGAAACTGCCCAGAGCTCACACATGCTTTAATCGCCTTGACTTACCTCCATATGAAACCTTTGAAGATTTACGAGAGAAACTTCTCATGGCCGTGGAAAATGCTCAAGGATTTGAAGGGG TGGATTAAGCACCCTGTGCCTCGGGGGTGGTTGTTCTTCAAGCAAGTTCTGCTTGCACTTTTGCATTTGCCTAACAGACTTTTGCAGAGGCGATGGCAGAGAGCAGCTGCAGGCATGGTC CCTGGAGCCGAGCCTTCACCACGCACTCGTCCAAGTTCGGATGCGGGAACCTGGTCCCAGCTTGAGTTCCTGCCTTTCCCACCACAAATTATCAACTGGTTGATGTGTACACTAATTACA TTTCAGGAGGACTTAATGCTATTTATGTTGTGCCTCTGCAGGCAAAGCCCTTAATAAATATTTTACATCCTTTCTAATGACAATGAATGGAATTAATCACTCAACAGGTATAGTATTACG ACTCATGTTTACTTTTTAAAATGATTTAGACCGATTTTCAGATTTTATTTCGTTATGATTAAAGATGTCTCATGTACTTGGAAAAGTGAGCATTTTTTTTTTTTTTGTATTTCACTTTCA TACCAGGCTTAATGTCAATGACATTTTTATTTTTGAAGTACTCTGACACCTCCACCCTCTACTTTATTAGAATTGGAAGGCAAATTTTTGTCCAAAAACCTACAGACAAGTACTTTGAGA GAATTTCCAATATAATATTAGACATAATGATAATTTTTTCCATACTCAGAATGAAAAACTGGATATTACGTTTTTGTTTTGGGGTTTTTTTGTACAAATTTAGCTAATAGCTACAGGCTG AGAGAATTGTAACATAGCATGACAAATTTTGTGTTGACTTGAAAGGAATCACACCATTATTCCTTAGAAGTAATTACATGTGTTCTAACACATTTGAGACAGGGTTGGACTCCCATTTCT CATCCGAGAAATTACTTAACCCTTCCTGGCGCTGTACAGTCATCTTTTATTCTATTTCCTCTTTGCTGTTTGTAGTAGAGACATTTTGAATGAAACTTGGCACTGCTTGATTCAAAACTG TGGAAACCAGATCTGTTTAGTCTCCTGTTTGTATGCGTTTGCTAATGGTAGCTAAATAACCAGTTTTTGTTGTAAATGCACCAATTCTGAAGGCACTTTATGTACTACATGGAGGTCATA TCTGGTTTTGTTTTTATTTTTTTATCATGAACATTAAATGTGATGATGATTTCTTTTCCCTGCACACATCTTTCCGGTGCAATATCTATCAATTGTGAATCTGGCTGCTGGTGTATAAAA ACCTGGATGTAAAGCTGAGCCTACAGACCTGTCCTCACCAACTGTTTTGTGATTTCTACTCAACTACAAAGATTTATTTAATGTACTCTTAATCTAACTGAGTTTTGTTACCAATGACCT GTTGCATGCTTCAATACCGTGTACTGCCTGAGTTGTGCCTCTTGTGTGCTAGATTAAAAGTGAGACAGAGACTTGACTTGATCCTCTGAGCTCAAGCTATTGAGCTGGTAGTGGCAGAGG ACTGAGGGTACCTGCACAGTTTGATTCTTTTCCACGTGTAAGTCTCCATTGCAGAATTGTCGTGCTTTGAGAAAACACCTGAGGCAGTGTGGGAGTTGAACGACCCTGCTGTCCTTTTTA ACCTGTGTTGTCCTAGACCCTGTCGGGGCAGTCAGGGGACACTAGAGATTTGATCTCATGCGAGTCATCAATAGGACAAAAAAGTTGTGGTTTGGGGAGGTCTGTTTGTTACATAAAAAG GACCTTTCGGTGTAAGAAATTGCCGTTTTTACCCTGCCCTGGCTGGCATGTGAGAAGCCATGGAAGGTTGTGGTTGTAAATGAGTTGTCTAAAGGGGTGCAGAGGCCTGAGGTTTCTAAA AGAAGGTAGATTTCTACAGAGCTGAGTGTTGGTTCCTTTTTCTTATTGGTTGAAAATTACCTGGTAGTGATCAGAAAACTTAGATGCTATGTAACTAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAATTCCCGCTCATGAGTTTTGACTATTGGTGAGATGTTTTCCGCTACAGTTAACATGACAAATGTCTCAGTGGCAAAAATCCCCTTTTTGTAAGCCCCCATAGTCTAGA GGCAGTTTTCTTTTTAAGAATCATGCCAGAGCCTGAGTCGAGCAGTATGCTTTCTTGGTTTTTGAGAGTAATTGTGTAATTGTAGAGGGAGAAATCCAATTCTAACCTAAGAACTGGGAT TCTTCTGTCATCTTGTAAACCGTATATTGAAAAAAACAGAATGTCACTAAATGCATATTAAGTCAAGTATTGGAAAGTATAAAAGAAAAATCATTCTGACAATTTCTAAGCCAGAAGCAA ACAAGAATTACTGAAATCTACCCCATGAATACTTGGAAGGCAGTAATTGTGAGTGACACCTCAGTTCATCAACCCCTTAATAATATCAGCTTAATTTTAATGACAACTAAATATGCTGAA GTGAGGATTTAGTATTTTTTAAAAAAGCAAAACAAGGTTCAGTAGTCCTCAGCAATTCTCCAAGTTTCTCTCTTTGCCTAAAATGGTCATAGATCTTGATTTCTCTGAATCGTGATGACC ACACCCAGTCATCTTCACAGCATAATTGCAGGTGGCAGTAAAGAGAGTGTGCTGGGTAAGGAGCAGTTGCTGGGTCATTCCTTGGGCCCCGACCTGCCCGGGGAGTAGCCCTGGGGGAGA GAGGGCAGTGTTGCCTATCCCAGAGGTCCCAGCAGTCACACTGCTCTGCAGGCCGGGCTCTCTTTATAGCCAGAGAAATCACCTTAATGCAGTCTCTTTAGTTGTCTGCTGAAGCTGTAG TTATTATGGGCCACTTACATGAGGCTGAGAAGTACGTGCCGGAGCTCACACACTGCCTGTTGCGGTTCTCTTAACATCAGTTATCACAGCTGCCTGTGGGTCCCGGGTATTTCCATTCCT GCCCCTTGTTGGCCCGAGGAAGGATGTGGAAAGAGCACCTGGTGGGATGAAGGTCCAACAGCCTGTGCCTCTCCACTGCTGGCCCTGGAGCCGGCAGCAGTGAGGCATTCATTGTCTGTG TTGCGGTGTATTCCCAGCTTCAGTGCTCTTTTCCTTTTTGCCTGAAATGTTTATGCTTCTCTGCAGCCAGTCCTCTAACAAATCTCAAGAACAAAGGTAAGACACTTGGTTTTTGTTTCC AGGACCCTTCAGAAGGTGACATCAGATATTCCCTAAATTCAGACAATGAGGGATACAGAGCGACTTGGCATGTATTATTTCTCCCATGTAAGGACAAAGGGACAGATTATTATTGTTATT TCTGAGACAGAGTCTTGCTCTGTAGCTCAGGCTGGAGTGCAGTGGCTCAATCTCAGCTCACCACAACCTCTGCCTCCTGGCTTCAAGCGATTCTTCTGCCTCAGCCTCCCCGAATAGTTG GGATTACAGGCACCCACCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTTTCACCATGCTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCGCCTCAGCC TTCCAAAGTGCTGGGATTACAAGCATGAGCCACCGCACCCGGCCTCACAGTGACAGATTCTGAGAAACAGCATGCAAAACATTTGAACCATTTTCTACATCTCCCATTGTTGCATAGAGA GTGTGCACCGCTGCTATCTTGCCAGATCCACACTGGTCCTCCCGAAAGCCAGGTTCATACACAGCAACTTTTTAATTATTCTAACAGTTACCCATTAACAGTCGACTCCTGTATTTCTGA GAGTCTTGTACTCACCTCTGAAATTTAAAAACGTATAAAGAGAGCCTGGGTTAATCAGTTCTGCAGCCCCTACGTGACACTGTGCTAGTTCTCCTTCTTCTGTCTCCTCCTTACCCTGGC CCTGCACCCCTGTACTTAAGAGGGAGAGGTGGGAGGTGCTGTCTGGTATCATTTGCTGCCTCGCCAGTAGAGGGTGCCGCTGTGCAGGGTAACTGCCCGCCTGCTCCCTTCCTGACCTCC CCTGACCCCGAAGATCACTACCTCTGTCATTCAGGCATTGGGGTACATCCTGATAAGTCGTGTCAGAACTGCCAATTTCAGGACTGAGATGTGTTTTTAAAAAACAAATCCTTATAAACT CCACTTTGTACTTTAGATTTTAAAACTGGGGAAAAATGTGATATTCTTTGGACCACTTTTTTAATTTATATAAGCCTTAATGAACAGTGTCTATACATTTGCATACACACACCCCCACCC CAGAGTGTTCTCAGTATGTCAGAGAAAGTGCCACAGCATTAGGACGGGAGCTTGGAGAACGTTTTCTAGAAAAGGGTTAGCTTCCTGTTGGCATGAAATTTTCCAAGCAAACCTCATTAA ACATCTGTTGTTTGTTAAAGATGTTCCACTGAAAGCAACGCATGTTTCAAAGGCACGTCTTTCCGTTCGTTGGTTTTCTGTGTGTAAGGAGTAGCATTGCTGTTGGCGCCTAACCTCGCG TGCACTGCATTCTCAACCCCGTACCAGTGCATCATCAGAAGCCTTCCTCGTGACCATAACTCTGTGTCTGCAGATATGTGTTCCCGTGTAAGCCAGTTTTCCCCTTTTACTCAGACTGAT TTCACCTAGATTGTCACGGTTTCCTTCATGTTAACTTTGCGTGACTTTGTTCTTCCTTTACTACTCTGTATGTAATATATATACATATATACGTACATATGCTGTCCAAATATATTTGTA TATATTTGTATAGCATTTTTACACCTTTATTGAGTAATCTGGTTTCGAAAGGAGGTGAGAGTTTAGTCCCTTCTGCAGTTTTCTCCAAGCTGTGTCCTGTGAATTTCAACCCTTGGAGCC TAAGAAAACCCTAGGAAGATGATGTTAATTTGCTGTCATTTCCTAATTCAGGATCTATCATCAAATGAAACATGAAAAAAACAGTGACTTTTAAGGTGAAAAGAGTTTCAAGCATTCCAA ATAAATTATCAATGTTTCATAACTTTTTATTATAAACCCACCTCCTAATAGGAAGCCAAGTACTATTTGATACAGTGGTAAAAACCAAACTACCTTGAATTTTTTTAAGGCAACTTATGA ATAATGCTCATTTTCACAGTCAGAATAGCTTTAAAATATGGTTGAATTTGATACACACAGGAAGTTTTCTTGAAGAACAATCCTTTCGCTTTTCTTTTTTCTTGAGAGATCTAAAGAGAA ACTGTAGATTGTTTTCCTGACAGCAAAAGACTAATGTGACAAAATGAAGTCATTGTAAAGAAGCGATGCAACTTGTCAAATATTTAATAAAGAATTATGGAAGCTGGAACATTTTCTACA |
Protein Sequence | >23327 : length: 1019 MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASFCSIAVELFFGRDIRKITKCESDNSNDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVF DENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNH NNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREP SSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTL SAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVL CGENDTRESVPSYDSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMF NPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSE IMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAEL YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD |