| Gene ID | 1571 |
| Symbol | CYP2E1 |
| Synonymous | CPE1|CYP2E|P450-J|P450C2E |
| Full name | cytochrome P450, family 2, subfamily E, polypeptide 1 |
| Gene description | 4-nitrophenol 2-hydroxylase|CYPIIE1|cytochrome P450 2E1|cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1|cytochrome P450-J|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase |
| Cytoband | 10q26.3 |
| Gene type | protein-coding |
| Synonymous | MIM:124040; HGNC:HGNC:2631; Ensembl:ENSG00000130649; HPRD:11813; Vega:OTTHUMG00000019322 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Metabolism of xenobiotics by cytochrome P450;KEGG PATHWAY;hsa00980 |
Pathway | methylglyoxal degradation III;BioCyc;PWY-5453 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Biological oxidations;Reactome;REACT:13433 |
Pathway | mechanism of acetaminophen activity and toxicity;PID BioCarta;100256 |
Pathway | oxidative ethanol degradation III (microsomal);BioCyc;PWY66-161 |
Pathway | Linoleic acid metabolism;KEGG PATHWAY;hsa00591 |
Pathway | Drug metabolism - cytochrome P450;KEGG PATHWAY;hsa00982 |
Pathway | acetone degradation I (to methylglyoxal);BioCyc;PWY-5451 |
Pathway | CYP2E1 reactions;PID Reactome;500199 |
Pathway | Arachidonic acid metabolism;KEGG PATHWAY;hsa00590 |
Disease | liver disease;GAD |
Disease | HEMATOLOGICAL;GAD |
Disease | preterm birth;GAD |
Disease | bronchitis;GAD |
Disease | oral cancer;GAD |
Disease | genetic polymorphism;GAD |
Disease | lung cancer;GAD |
Disease | Parkinson's disease;GAD |
Disease | METABOLIC;GAD |
Disease | alcoholism;GAD |
Disease | benzene toxicity;GAD |
Disease | colorectal cancer;GAD |
Disease | tuberculosis;GAD |
Disease | CHEMDEPENDENCY;GAD |
Disease | aplastic anemia, acquired;GAD |
Disease | CANCER;GAD |
Disease | Liver Cirrhosis;GAD |
Disease | INFECTION;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | REPRODUCTION;GAD |
Disease | pneumonia;GAD |
Disease | liver cancer;GAD |
Disease | adult brain tumors;GAD |
Sequence Information | |
|---|---|
Nucleotide Sequence | >1571 : length: 1667 CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGC TGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGTTGGCCCAGCGCTTCGGGCCGGTGTTCACG CTGTACGTGGGCTCGCAGCGCATGGTGGTGATGCACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCAC AGGGACAGGGGAATCATTTTTAATAATGGACCTACCTGGAAGGACATCCGGCGGTTTTCCCTGACCACCCTCCGGAACTATGGGATGGGGAAACAGGGCAATGAGAGCCGGATCCAGAGG GAGGCCCACTTCCTGCTGGAAGCACTCAGGAAGACCCAAGGCCAGCCTTTCGACCCCACCTTCCTCATCGGCTGCGCGCCCTGCAACGTCATAGCCGACATCCTCTTCCGCAAGCATTTT GACTACAATGATGAGAAGTTTCTAAGGCTGATGTATTTGTTTAATGAGAACTTCCACCTACTCAGCACTCCCTGGCTCCAGCTTTACAATAATTTTCCCAGCTTTCTACACTACTTGCCT GGAAGCCACAGAAAAGTCATAAAAAATGTGGCTGAAGTAAAAGAGTATGTGTCTGAAAGGGTGAAGGAGCACCATCAATCTCTGGACCCCAACTGTCCCCGGGACCTCACCGACTGCCTG CTCGTGGAAATGGAGAAGGAAAAGCACAGTGCAGAGCGCTTGTACACAATGGACGGTATCACCGTGACTGTGGCCGACCTGTTCTTTGCGGGGACAGAGACCACCAGCACAACTCTGAGA TATGGGCTCCTGATTCTCATGAAATACCCTGAGATCGAAGAGAAGCTCCATGAAGAAATTGACAGGGTGATTGGGCCAAGCCGAATCCCTGCCATCAAGGATAGGCAAGAGATGCCCTAC ATGGATGCTGTGGTGCATGAGATTCAGCGGTTCATCACCCTCGTGCCCTCCAACCTGCCCCATGAAGCAACCCGAGACACCATTTTCAGAGGATACCTCATCCCCAAGGGCACAGTCGTA GTGCCAACTCTGGACTCTGTTTTGTATGACAACCAAGAATTTCCTGATCCAGAAAAGTTTAAGCCAGAACACTTCCTGAATGAAAATGGAAAGTTCAAGTACAGTGACTATTTCAAGCCA TTTTCCACAGGAAAACGAGTGTGTGCTGGAGAAGGCCTGGCTCGCATGGAGTTGTTTCTTTTGTTGTGTGCCATTTTGCAGCATTTTAATTTGAAGCCTCTCGTTGACCCAAAGGATATC GACCTCAGCCCTATACATATTGGGTTTGGCTGTATCCCACCACGTTACAAACTCTGTGTCATTCCCCGCTCATGAGTGTGTGGAGGACACCCTGAACCCCCCGCTTTCAAACAAGTTTTC AAATTGTTTGAGGTCAGGATTTCTCAAACTGATTCCTTTCTTTGCATATGAGTATTTGAAAATAAATATTTTCCCAGAATATAAATAAATCATCACATGATTATTTT |
Protein Sequence | >1571 : length: 493 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC IPPRYKLCVIPRS |