| Gene ID | 1326 |
| Symbol | MAP3K8 |
| Synonymous | AURA2|COT|EST|ESTF|MEKK8|TPL2|Tpl-2|c-COT |
| Full name | mitogen-activated protein kinase kinase kinase 8 |
| Gene description | Ewing sarcoma transformant|augmented in rheumatoid arthritis 2|cot (cancer Osaka thyroid) oncogene|proto-oncogene c-Cot|proto-oncogene serine/threoine protein kinase|tumor progression locus 2 |
| Cytoband | 10p11.23 |
| Gene type | protein-coding |
| Synonymous | MIM:191195; HGNC:HGNC:6860; Ensembl:ENSG00000107968; HPRD:01863; Vega:OTTHUMG00000017889 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Ras signaling in the CD4+ TCR pathway;PID Curated;200088 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | CD28 dependent PI3K/Akt signaling;PID Reactome;500485 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Interleukin-1 signaling;PID Reactome;500490 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Disease | Lung cancer, somatic;OMIM |
Sequence Information | |
|---|---|
Nucleotide Sequence | >1326 : length: 4870 GCAGCTCGGAGGCTGGAGGACCCGATCCTCCCAAATGCTGGGTGCTTTGATAATTTATAAGCCTTTTAGGCTCCCTTGACTTAGAGAACCAGGAGGAAAGGAGTGGGAGTGTGGGTTGGC GGAGCCCAGAGACTTGTGAATGGCTGGAACTAAATTCAAGTTTGTAACCCGGACTCTATCCCATGACTAAAGAGGTCATAGCAGAACACGAAGGCTGGGCTTTTGGTCTAAGAAAGAATA CTAGGAGAAAAAAAAAGTTATTTTCACGGAAGTTGTTTTCGAGCGATAGTGCATGATCAGGACTCTGAAATTTTTCTAGCTCTGGGCGGAGAAGGACGCCTAGGGATTGTCTCCATAGTT AACAGGGGAAGGCCACCGGCTGCCTGTAAGAGAGAAACGTTGCGATGCTTGTCTATTTCACTTTTGGGAAGACAAGATTAAAGGCTGCTCTTGATAAAAAACAGGGACAGAAAGGCTCTT GCAGTTGCTTTACATACCTGTGGCCTGAGTCGTTTGTGCCAAGGAGAGTGTAATCCACTTCCAGCTGACGCCCCCAGCTCTCTGCGACGGATTGAGGTTTGTGTGCAGGACGTCTGGCAT ACGGCCCATGAGGACTTTGTCGTGTAAAGCAAATGGGAACGTTGAGGCATGTAGAGGTTTTGAAGCAGAGTGTCGGTCCTTCCTTCCATACGCCTGAAACGCATAATCCGGGGCTTTTTG AGAGCAAAAACATAGTCAGAAATGTGCCCTGAGGGAGAATGTACTATTTTGGCACACATATGTATATATGTATATATAATTTTTAAATTTTTTTTGAGAGGGGGTTTCACTCTTGTCGCC CAGGCTGGAGCGCAATGGCGCGATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCCCGCCGCCACGCCCG GCTAATTTTTGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATGCACCCTCCTTGGCCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACTG TGCCCGGCCTAAAAAAATATTTTAAATGAGAAATAACACAAGTAATAGTCATTCTTTGTTAGGCAGAAGCATATGCTGTTATGCTGGCCATTTTCATTCACACTTGCCAGGAAACACTCA CATTTTGTTTCTGTATATGGAGGCAGCCAAGAGTATTATGTTAATGTTTAGGAAGAGAATTTCCTCGTGATTTTATTGCTGATTTCTGAAATAATTCAGTGTAACTAATTTTGACTGTAT TTGCACATCTCTCCAATTCCAAAAGCTGGCATAATTTTCTGTTTGGTTAGGAAGTAGGAATTTTATGAGGACTTTTATTGTAAACTGTGTCAAGGGAAAAATCATCTTATACTAAACGTC TTTATTGCCAAACTAGAATACCTTCACAATCTGAACTTTCTCTAGATGGGCACAGATCATGAATAACTCAGAAACCATTAGCATATTGTGTGCTTAATTAAGGCTGGAAAGTGCTGAGGC TTTTTGCAGGCGCAGTTAGCAGGCGAACTGGTCAGCAGGGTTTCTGGGGAACGTAGATTTGCGTGACAGGGGCCCTGTGTTGCTAAGGAATTACTGCAGGCACTGAGAAAAGTCTCAGCG TCAGACACTCCTCCACCTCCCGGGTCCTGCTTCCCTCCCTCTCCCCTTTCCAGGCAACTCACAGTTTAGGGGTGTGGTTGTGTGTGTTCAAGCTCTTGGGTTTTACATATAAATGCCTGA GACTTTTCTGCAGGGTTTAAAAACTAACATCTTGTCTTACAGCTCTTTTAGGATTTGTCTTTTAGAATCTCCAGTCCTCACAGGAAAACCCCCCAATTAAAAAAATAAAAGAATAAAGAA TAAAAAGAATACCACTACTACTATAAAAAAAAAAAAAATCCTCTAAAATTTGTCTTCCCAGATCAGCAGAGTGAATTTGAACTGTGTGGACTTTTTTCCTCTTTCTTTCTTGAGTCATGT TAGTACTGAGAACTTTTTTTTTTTCTGTCAAATCATCTGTTTGATAAATAAGTCCAGGAGACTTGGATCCTTTCAACCCCTGAGGCCCTAAATTAGGCTGTTTTTTTTTTAACCTCTGTG TTTCCAGTAAATTCGACAAGCAGAAACTGCAACTAAACGGCTCAGTAAAACCGAAGTCAAATGTTCCTCCATTAATCTAAGAAGTTGCTCTCCTAACTCAGCAGACTCCAAGAACCTGAA TCACAATCTCCCTCGAAGATGTACAAGATCTCAGGAGGGGAAGCTGCCCCCTCACTCTAGATTTCACGGTGGTGATAACAGCCATGAAAGCATTTCATAGACTCTCCAGAAAGAGCAACA GTAATGGAGTACATGAGCACTGGAAGTGACAATAAAGAAGAGATTGATTTATTAATTAAACATTTAAATGTGTCTGATGTAATAGACATTATGGAAAATCTTTATGCAAGTGAAGAGCCA GCAGTTTATGAACCCAGTCTAATGACCATGTGTCAAGACAGTAATCAAAACGATGAGCGTTCTAAGTCTCTGCTGCTTAGTGGCCAAGAGGTACCATGGTTGTCATCAGTCAGATATGGA ACTGTGGAGGATTTGCTTGCTTTTGCAAACCATATATCCAACACTGCAAAGCATTTTTATGGACAACGACCACAGGAATCTGGAATTTTATTAAACATGATCCCACCAACATCCAGCAAG ATCTGGGGAAGAAGCTTTGGGAGACTAACCTGGGAATTGCTTTGGGTCATCACTCCCCAAAATGGACGTTACCAAATAGATTCCGATGTTCTCCTGATCCCCTGGAAGCTGACTTACAGG AATATTGGTTCTGATTTTATTCCTCGGGGCGCCTTTGGAAAGGTATACTTGGCACAAGATATAAAGACGAAGAAAAGAATGGCGTGTAAACTGATCCCAGTAGATCAATTTAAGCCATCT GATGTGGAAATCCAGGCTTGCTTCCGGCACGAGAACATCGCAGAGCTGTATGGCGCAGTCCTGTGGGGTGAAACTGTCCATCTCTTTATGGAAGCAGGCGAGGGAGGGTCTGTTCTGGAG AAACTGGAGAGCTGTGGACCAATGAGAGAATTTGAAATTATTTGGGTGACAAAGCATGTTCTCAAGGGACTTGATTTTCTACACTCAAAGAAAGTGATCCATCATGATATTAAACCTAGC AACATTGTTTTCATGTCCACAAAAGCTGTTTTGGTGGATTTTGGCCTAAGTGTTCAAATGACCGAAGATGTCTATTTTCCTAAGGACCTCCGAGGAACAGAGATTTACATGAGCCCAGAG GTCATCCTGTGCAGGGGCCATTCAACCAAAGCAGACATCTACAGCCTGGGGGCCACGCTCATCCACATGCAGACGGGCACCCCACCCTGGGTGAAGCGCTACCCTCGCTCAGCCTATCCC TCCTACCTGTACATAATCCACAAGCAAGCACCTCCACTGGAAGACATTGCAGATGACTGCAGTCCAGGGATGAGAGAGCTGATAGAAGCTTCCCTGGAGAGAAACCCCAATCACCGCCCA AGAGCCGCAGACCTACTAAAACATGAGGCCCTGAACCCGCCCAGAGAGGATCAGCCACGCTGTCAGAGTCTGGACTCTGCCCTCTTGGAGCGCAAGAGGCTGCTGAGTAGGAAGGAGCTG GAACTTCCTGAGAACATTGCTGATTCTTCGTGCACAGGAAGCACCGAGGAATCTGAGATGCTCAAGAGGCAACGCTCTCTCTACATCGACCTCGGCGCTCTGGCTGGCTACTTCAATCTT GTTCGGGGACCACCAACGCTTGAATATGGCTGAAGGATGCCATGTTTGCTCTAAATTAAGACAGCATTGATCTCCTGGAGGCTGGTTCTGCTGCCTCTACACAGGGGCCCTGTACAGTGA ATGGTGCCATTTTCGAAGGAGCAGTGTGACCTCCTGTGACCCGTGAATGTGCCTCCAAGCGGCCCTGTGTGTTTGACATGTGAAGCTATTTGATATGCACCAGGTCTCAAGGTTCTCATT TCTCAGGTGACGTGATTCTAAGGCAGGAATTTGAGAGTTCACAGAAGGATCGTGTCTGCTGACTGTTTCATTCACTGTGCACTTTGCTCAAAATTTTAAAAATACCAATCACAAGGATAA TAGAGTAGCCTAAAATTACTATTCTTGGTTCTTATTTAAGTATGGAATATTCATTTTACTCAGAATAGCTGTTTTGTGTATATTGGTGTATATTATATAACTCTTTGAGCCTTTATTGGT AAATTCTGGTATACATTGAATTCATTATAATTTGGGTGACTAGAACAACTTGAAGATTGTAGCAATAAGCTGGACTAGTGTCCTAAAAATGGCTAACTGATGAATTAGAAGCCATCTGAC AGCAGGCCACTAGTGACAGTTTCTTTTGTGTTCCTATGGAAACATTTTATACTGTACATGCTATGCTGAAGACATTCAAAACGTGATGTTTTGAATGTGGATAAAACTGTGTAAACCACA TAATTTTTGTACATCCCAAAGGATGAGAATGTGACCTTTAAGAAAAATGAAAACTTTTGTAAATTATTGATGATTTTGTAATTCTTATGACTAAATTTTCTTTTAAGCATTTGTATATTA AAATAGCATACTGTGTATGTTTTATATCAAATGCCTTCATGAATCTTTCATACATATATATATTTGTAACATTGTAAAGTATGTGAGTAGTCTTATGTAAAGTATGTTTTTACATTATGC AAATAAAACCCAATACTTTTGTCCAATGTGGTTGGTCAAATCAACTGAATAAATTCAGTATTTTGCCTTA |
Protein Sequence | >1326 : length: 594 MEGAPSRGENSGVGRGGGVPTAALAGRRLHQAQLESTLRKGLTGCRLATPPPSSSFPYPQRQGSAGLGSARGSGDPLSLRLPLPTPPGRPHSPCPRPDSPERATVMEYMSTGSDNKEEID LLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMIPPTSSKIWGRSFGRLTWELLWV ITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWV TKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDI ADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG |