| TopoI(h) --Caspase-3(h)--> protein remnants (processing)
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TopoI(h) + Abl(h) <==> TopoI(h):Abl(h) (binding)
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TopoI(h) + Abl(m.s.) <==> TopoI(h):Abl(m.s.) (binding)
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TopoI(h) + ATP --Abl(h)--> TopoI(h){pY} + ADP (phosphorylation)
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TopoI(h) + ATP --Abl(m.s.)--> TopoI(h){pY268} + ADP (phosphorylation)
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TopoI(h) + ATP --Abl(h)--> TopoI(h){pY268} + ADP (phosphorylation)
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c-Jun(m.s.) + TopoI(h) + hnRNPM(h) + Gu-alpha(h) + RHA(h) <==> c-Jun(m.s.):TopoI(h):hnRNPM(h):Gu-alpha(h):RHA(h) (binding)
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c-Jun(m.s.) + TopoI(h) <==> c-Jun(m.s.):TopoI(h) (binding)
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c-Jun(h) + TopoI(h) <==> c-Jun(h):TopoI(h) (binding)
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TopoI(h) + c-Jun(h) + TBP(h) <==> TopoI(h):c-Jun(h):TBP(h) (binding)
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TopoI(h) + c-Jun(h){p} <==> TopoI(h):c-Jun(h){p} (binding)
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WS(h) + TopoI(h) <==> WS(h):TopoI(h) (binding)
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MGMT(h) + TopoI(h) <==> MGMT(h):TopoI(h) (binding)
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TopoI(h) + AR-isoform1(h) <==> TopoI(h):AR-isoform1(h) (binding)
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TopoI(h) + AR(h) <==> TopoI(h):AR(h) (binding)
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p16INK4a-p14(h) + TopoI(h) <==> p16INK4a-p14(h):TopoI(h) (binding)
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TOP1(h) --> TopoI(h) (expression).
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TopoI(h){pY} --SHP-1(m.s.)--> TopoI(h) + p (dephosphorylation)
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c-Jun(h) + TopoI(h) <==> c-Jun(h):TopoI(h) (binding)
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TopoI(h) + sumo1(m.s.) --Aos1(m.s.):SAE2(m.s.),Ubc9(h)--> TopoI(h){sumoK117} (sumoylation)
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TOP1(h) --> TopoI(h) (expression).
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