| E2-C(h) --/ cyclinA(h) (decrease of abundance)
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E2-C(h) --> Cdc20(h):MAD2(h) (decrease of binding)
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E2-C(h) + n ubiquitin(h) --> E2-C(h){ub}n (ubiquitination; automodification)
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UBE2C(h) --> E2-C(h) (expression).
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cyclinB(h) + n ubiquitin(b) --E1(h),E2-C(h),cyclosome(m){p}n--> cyclinB(h){ub(n)} (ubiquitination)
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securin(fy) + n ubiquitin(b) --E1(m),E2-C(h),cyclosome(m):Cdc20(h){p}--> securin(fy){ub(n)} (ubiquitination)
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cyclinB(h) + n ubiquitin(b) --E1(m),E2-C(h),cyclosome(m):Cdc20(h){p}--> cyclinB(h){ub(n)} (ubiquitination)
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cyclinB(h) + n ubiquitin(b) --E1(m),E2-C(h),cyclosome(m):Fzr(h)--> cyclinB(h){ub(n)} (ubiquitination)
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Skp2(h) + n ubiquitin(v.s.) --E1(v.s.),E2-C(h),cyclosome(x):Fzr(h)--> Skp2(h){ub(n)} (ubiquitination)
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E1(h){ub} + E2-C(h) --> E1(h) + E2-C(h){ub} (ubiquitination; conjugation)
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UBE2C(h) --> E2-C(h) (expression).
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Aurora-B(h) + n ubiquitin(h) --E2-C(h),cyclosome(x):Fzr1(h)--> Aurora-B(h){ub(n)} (ubiquitination)
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Aurora-B(h) + ubiquitin(h) --E2-C(h),cyclosome(x):Cdc20(h)--> Aurora-B(h){ub} (ubiquitination)
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TPX2(h) + n ubiquitin(h) --E2-C(h),cyclosome(x):Fzr1(h)--> TPX2(h){ub}n (ubiquitination)
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