| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 8660 |
Name | IRS2 |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for IRS2 |
| Links to the AnimalTFDB for IRS2 |
Regulation From TransFac database | IRS-2(h) + Grb-2(h) <==> IRS-2(h):Grb-2(h) (binding) | IRS-2(h) + crkII(h) <==> IRS-2(h):crkII(h) (binding) | IRS-2(h) + NTP --Jak2(v.s.)--> IRS-2(h){pY} + NDP (phosphorylation) | IRS-2(h) + ATP --> IRS-2(h){pY} + ADP (phosphorylation) | IRS-2(h) + PLCgamma1(h) <==> IRS-2(h):PLCgamma1(h) (binding) | Jak1(h) + IRS-2(h) <==> Jak1(h):IRS-2(h) (binding) | 14-3-3beta(h) + IRS-2(h) <==> 14-3-3beta(h):IRS-2(h) (binding) | 14-3-3gamma(h) + IRS-2(h) <==> 14-3-3gamma(h):IRS-2(h) (binding) | 14-3-3tau(h) + IRS-2(h) <==> 14-3-3tau(h):IRS-2(h) (binding) | 14-3-3sigma(m.s.) + IRS-2(h) <==> 14-3-3sigma(m.s.):IRS-2(h) (binding) | IRS2(h) --> IRS-2(h) (expression). | atad2(h) --> IRS-2(h) (increase of abundance) | IRS2(h) --> IRS-2(h) (expression). | IRS2(h) --> IRS2(h) (expression). | hsa-miR-7 --/ IRS2(h) (translational repression). |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 309 | Phosphoserine. | Swiss-Prot 53.0 | 346 | Phosphoserine. | Swiss-Prot 53.0 | 350 | Phosphothreonine. | Swiss-Prot 53.0 | 388 | Phosphoserine. | Swiss-Prot 53.0 | 391 | Phosphoserine. | Swiss-Prot 53.0 | 520 | Phosphothreonine. | Swiss-Prot 53.0 | 527 | Phosphothreonine. | Swiss-Prot 53.0 | 540 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 560 | Phosphoserine. | Swiss-Prot 53.0 | 577 | Phosphoserine. | Swiss-Prot 53.0 | 580 | Phosphothreonine. | Swiss-Prot 53.0 | 653 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 675 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 915 | Phosphoserine. | Swiss-Prot 53.0 | 919 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 978 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 1100 | Phosphoserine. | Swiss-Prot 53.0 | 1176 | Phosphoserine. | Swiss-Prot 53.0 | 1203 | Phosphoserine. | Swiss-Prot 53.0 | 1253 | Phosphotyrosine (by INSR) (Bysimilarity). | Swiss-Prot 53.0 | 915 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 520 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 1203 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 1100 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 1149 | Phosphoserine | 15364919 | Phospho.ELM 6.0 | 823 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 675 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 653 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr13 |
Promoter: 109236415 - 109238415 | Agilent_014791 |
chr13 |
Promoter: 109236415 - 109238415 | GSE27584 |
chr13 |
Promoter: 109236415 - 109238415 | Agilent_014791_44K |
chr13 |
Promoter: 109236415 - 109238415 | PMID:16367923 |