| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6198 |
Name | RPS6KB1 |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for RPS6KB1 |
| Links to the AnimalTFDB for RPS6KB1 |
Regulation From TransFac database | p70S6K1-alpha2(h) + ATP --> p70S6K1-alpha2(h){pT389} + ADP (phosphorylation) | p70S6K1-alpha2(h) + 3 ATP --> p70S6K1-alpha2(h){pT389}{pT421}{pS424} + 3 ADP (phosphorylation) | p70S6K1-alpha2(h) + ATP --> p70S6K1-alpha2(h){p} + ADP (phosphorylation) | RPS6KB1(h) --> p70S6K1-alpha2(h) (expression). | rps6(v.s.) + ATP --p70S6K1-alpha2(h)--> rps6(v.s.){p} + ADP (phosphorylation) | p70S6K1-Alpha1(h) + ATP --PDK1(h){pS241}--> p70S6K1-Alpha1(h){pT252}{pT412} + ADP (phosphorylation) | p70S6K1-Alpha1(h) + ATP --> p70S6K1-Alpha1(h){p} + ADP (phosphorylation) | RPS6KB1(h) --> p70S6K1-Alpha1(h) (expression). | p70S6K1(h) + ATP --> p70S6K1(h){pT389} + ADP (phosphorylation) | p70S6K1(h) + 2 ATP --> p70S6K1(h){pT421}{pS424} + 2 ADP (phosphorylation) | p70S6K1(h) + ATP --> p70S6K1(h){p} + ADP (phosphorylation) | p70S6K1(h) + ATP --> p70S6K1(h){pT} + ADP (phosphorylation) | RPS6KB1(h) --> p70S6K1(h) (expression). | p70S6K1(h){pT389} --> p70S6K1(h) + p (dephosphorylation) | rps6(m.s.) + ATP --p70S6K1(h)--> rps6(m.s.){p} + ADP (phosphorylation) |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 441 | Phosphoserine. | Swiss-Prot 53.0 | 444 | Phosphothreonine. | Swiss-Prot 53.0 | 447 | Phosphoserine. | Swiss-Prot 53.0 | 441 | Phosphoserine (PDK-1) | 9271440;17081983 | Phospho.ELM 6.0 | 427 | Phosphoserine (PDK-1) | 9271440 | Phospho.ELM 6.0 | 434 | Phosphoserine (CDK1;mTOR;PD) | 9271440;12586835;11914378;14993219;15208671;158093 | Phospho.ELM 6.0 | 470 | Phosphothreonine (PDK-1) | 9271440 | Phospho.ELM 6.0 | 444 | Phosphothreonine (CDK1;mTOR) | 12586835;11914378;17081983 | Phospho.ELM 6.0 | 447 | Phosphoserine (CDK1;mTOR) | 12586835;11914378;17081983 | Phospho.ELM 6.0 | 252 | Phosphothreonine (PDK-1) | 9445476 | Phospho.ELM 6.0 | 390 | Phosphothreonine (mTOR;PDK-1) | 9271440;12370290;9465032;11914378;14560963 | Phospho.ELM 6.0 | 394 | Phosphoserine (CDK1;mTOR) | 12586835;11914378;14993219 | Phospho.ELM 6.0 | 412 | Phosphothreonine (mTOR;p70S6K;) | 11914378;16099428;15809305;15718470;15388791 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 55323725 - 55325725 | GSE27584 |
chr17 |
Promoter: 55323725 - 55325725 | Agilent_014791 |