Entrez Gene

Basic Information
Gene ID	6198
Name	RPS6KB1

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1165C>G; p.Q389E; 17:59940881-59940881	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.127G>A; p.E43K; 17:59893311-59893311	breast	carcinoma	Substitution - Missense
c.1518_1519insA; p.Q509fs*>18; 17:59946728-59946729	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.636G>A; p.K212K; 17:59931670-59931670	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1492A>T; p.I498L; 17:59946702-59946702	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.442G>A; p.E148K; 17:59926495-59926495	urinary_tract; bladder	carcinoma	Substitution - Missense
c.442G>A; p.E148K; 17:59926495-59926495	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.338G>C; p.G113A; 17:59914660-59914660	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.506A>G; p.Y169C; 17:59926559-59926559	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.263C>T; p.P88L; 17:59912755-59912755	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.138delG; p.G48fs*3; 17:59893322-59893322	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.64G>A; p.E22K; 17:59893248-59893248	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.621G>A; p.G207G; 17:59931655-59931655	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.621G>A; p.G207G; 17:59931655-59931655	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.621G>A; p.G207G; 17:59931655-59931655	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.466G>A; p.V156M; 17:59926519-59926519	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.790A>G; p.I264V; 17:59934444-59934444	liver	carcinoma	Substitution - Missense
c.747_748delCA; p.T252fs*11; 17:59934228-59934229	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1003C>T; p.R335C; 17:59936239-59936239	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1515A>T; p.P505P; 17:59946725-59946725	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1119G>T; p.L373F; 17:59936541-59936541	thyroid	other; neoplasm	Substitution - Missense
c.1480G>A; p.A494T; 17:59946690-59946690	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1522A>C; p.K508Q; 17:59946732-59946732	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.990A>T; p.R330S; 17:59936226-59936226	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.682C>T; p.H228Y; 17:59931716-59931716	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1118T>C; p.L373S; 17:59936540-59936540	thyroid	other; neoplasm	Substitution - Missense
c.1402C>A; p.P468T; 17:59946612-59946612	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1026C>T; p.D342D; 17:59936262-59936262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1540A>G; p.I514V; 17:59946750-59946750	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.281T>G; p.L94R; 17:59912773-59912773	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.807C>T; p.G269G; 17:59934461-59934461	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.170G>A; p.G57E; 17:59910590-59910590	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1234A>G; p.T412A; 17:59945412-59945412	liver	carcinoma	Substitution - Missense
c.1542C>T; p.I514I; 17:59946752-59946752	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.598G>A; p.A200T; 17:59931632-59931632	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1092G>A; p.K364K; 17:59936514-59936514	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1114C>A; p.L372M; 17:59936536-59936536	breast	carcinoma	Substitution - Missense
c.1117T>C; p.L373L; 17:59936539-59936539	thyroid	other; neoplasm	Substitution - coding silent
c.717A>G; p.L239L; 17:59934198-59934198	breast	carcinoma	Substitution - coding silent
c.666G>C; p.E222D; 17:59931700-59931700	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1053C>A; p.F351L; 17:59936475-59936475	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.319C>G; p.Q107E; 17:59914641-59914641	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.814C>T; p.R272C; 17:59934468-59934468	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.828G>T; p.W276C; 17:59934482-59934482	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.135G>A; p.E45E; 17:59893319-59893319	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.866G>A; p.G289E; 17:59934520-59934520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.866G>A; p.G289E; 17:59934520-59934520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1125T>G; p.S375S; 17:59940841-59940841	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1045C>A; p.H349N; 17:59936467-59936467	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.382-7C>T; p.?; 17:59926428-59926428	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.283C>T; p.R95W; 17:59912775-59912775	breast	carcinoma	Substitution - Missense
c.283C>T; p.R95W; 17:59912775-59912775	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.867A>G; p.G289G; 17:59934521-59934521	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1295T>C; p.I432T; 17:59945473-59945473	skin	malignant_melanoma	Substitution - Missense
c.661C>T; p.P221S; 17:59931695-59931695	skin	malignant_melanoma	Substitution - Missense
c.1116G>T; p.L372L; 17:59936538-59936538	thyroid	other; neoplasm	Substitution - coding silent
c.1306C>T; p.R436*; 17:59945484-59945484	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.1306C>T; p.R436*; 17:59945484-59945484	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1467T>C; p.S489S; 17:59946677-59946677	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.525C>T; p.L175L; 17:59926578-59926578	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1119+7A>G; p.?; 17:59936548-59936548	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.772G>T; p.E258*; 17:59934253-59934253	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1131G>A; p.E377E; 17:59940847-59940847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.827G>T; p.W276L; 17:59934481-59934481	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.142G>A; p.G48S; 17:59910562-59910562	breast	carcinoma	Substitution - Missense
c.647A>G; p.Y216C; 17:59931681-59931681	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1488T>C; p.L496L; 17:59946698-59946698	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.1520A>G; p.K507R; 17:59946730-59946730	skin	malignant_melanoma	Substitution - Missense
c.865G>A; p.G289R; 17:59934519-59934519	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1444G>C; p.E482Q; 17:59946654-59946654	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database