Epithelial-Mesenchymal Transition gene database (dbEMT) Home
dbEMT
dbEMT 2.0
General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

4067

Name

LYN

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription factors   [Top]

The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget

Links to the hTFtarget for LYN
Links to the AnimalTFDB for LYN

Regulation From TransFac database

LynA(h) + PDE4D4(h) <==> LynA(h):PDE4D4(h) (binding)
LynA(h) + PDE4D4(r) <==> LynA(h):PDE4D4(r) (binding)
LynA(h) + RG4(h) <==> LynA(h):RG4(h) (binding)
lyn(h) --> LynA(h) (expression).
c-Kit(h){pY} + Lyn(h) <==> c-Kit(h){pY}:Lyn(h) (binding)
beta1A-integrin(v.s.) + Lyn(h) <==> beta1A-integrin(v.s.):Lyn(h) (binding)
beta2-integrin(v.s.) + Lyn(h) <==> beta2-integrin(v.s.):Lyn(h) (binding)
beta3-integrin(v.s.) + Lyn(h) <==> beta3-integrin(v.s.):Lyn(h) (binding)
Lyn(h) + uPAR(h) <==> Lyn(h):uPAR(h) (binding)
Lyn(h) + CIN85(m.s.) <==> Lyn(h):CIN85(m.s.) (binding)
Lyn(h) + ATP --> Lyn(h){pY} + ADP (phosphorylation; automodification)
Lyn(h) + SK1(h) <==> Lyn(h):SK1(h) (binding)
Lyn(h) + ATP --> Lyn(h){p} + ADP (phosphorylation; automodification)
Lyn(h) + GP1b(h) <==> Lyn(h):GP1b(h) (binding)
Syk(h) + Lyn(h) <==> Syk(h):Lyn(h) (binding)
Lyn(h) + Syk(m.s.) <==> Lyn(h):Syk(m.s.) (binding)
Lyn(h) + FcRgamma(h) <==> Lyn(h):FcRgamma(h) (binding)
Lyn(h) + Cas(r) <==> Lyn(h):Cas(r) (binding)
Lyn(h) + Cas(h) <==> Lyn(h):Cas(h) (binding)
HEF1(h) + Lyn(h) <==> HEF1(h):Lyn(h) (binding)
Lyn(h) + HCV-NS5A-1A-H77(HCV1AH77) <==> Lyn(h):HCV-NS5A-1A-H77(HCV1AH77) (binding)
ErbB1(h) + Lyn(h) <==> ErbB1(h):Lyn(h) (binding)
ErbB2(h){pY1023}{pY1139} + Lyn(h) <==> ErbB2(h){pY1023}{pY1139}:Lyn(h) (binding)
ErbB3-isoform1(h){pY1289} + Lyn(h) <==> ErbB3-isoform1(h){pY1289}:Lyn(h) (binding)
Lyn(h) + CIP4(h) <==> Lyn(h):CIP4(h) (binding)
CD66b(h) + Lyn(h) <==> CD66b(h):Lyn(h) (binding)
Lyn(h) + CD11B(h):beta2-integrin(h) + LFA-1(h) + Fgr(h) + Hck(h) + Fyn(h) <==> CD11B(h):beta2-integrin(h):uPAR(h):Lyn(h):Fyn(h):Hck(h):Fgr(h):LFA-1(h) (binding)
Lyn(h) + FcgammaRI alpha-A(h) <==> Lyn(h):FcgammaRI alpha-A(h) (binding)
Lyn(h) + ATP --> Lyn(h){pY397} + ADP (phosphorylation)
Lyn(h) + lactosylceramide <==> Lyn(h):lactosylceramide (binding)
Lyn(h) + CD89(h) <==> Lyn(h):CD89(h) (binding)
Lyn(h) + ATP --> Lyn(h){p} + ADP (phosphorylation)
Lyn(h) + ATP --> Lyn(h){pY} + ADP (phosphorylation)
PKCdelta(h) + Lyn(h) <==> PKCdelta(h):Lyn(h) (binding)
Cdk4(h) + Lyn(h) <==> Cdk4(h):Lyn(h) (binding)
IL-5Rbeta(m.s.) + Lyn(h) <==> IL-5Rbeta(m.s.):Lyn(h) (binding)
IL-5Rbeta(h) + Lyn(h) <==> IL-5Rbeta(h):Lyn(h) (binding)
Lyn(h) + IL-5Ralpha(h) <==> Lyn(h):IL-5Ralpha(h) (binding)
dynamin2(h) + Lyn(h) <==> dynamin2(h):Lyn(h) (binding)
Lyn(h) + Syk(h) <==> Syk(h):Lyn(h) (binding)
lyn(h) --> Lyn(h) (expression).
APS(m) + NTP --Lyn(h)--> APS(m){p} + NDP (phosphorylation)
p62Dok-1(h) + ATP --Lyn(h)--> p62Dok-1(h){pY} + ADP (phosphorylation)
Enolase(m.s.) + ATP --Lyn(h)--> Enolase(m.s.){p} + ADP (phosphorylation)
Src(m.s.) + ATP --Lyn(h)--> Src(m.s.){p} + ADP (phosphorylation)
PLCgamma2(h) + ATP --Lyn(h)--> PLCgamma2(h){pY753}{pY759} + ADP (phosphorylation)
IL-5Ralpha(h) + ATP --Lyn(h)--> IL-5Ralpha(h){pY} + ADP (phosphorylation)
IL-5Rbeta(h) + ATP --Lyn(h)--> IL-5Rbeta(h){p} + ADP (phosphorylation)
Sam68(m.s.) --Lyn(h)--> Sam68(m.s.){p} (phosphorylation)
LynB(h) + RG4(h) <==> LynB(h):RG4(h) (binding)
lyn(h) --> LynB(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

2N-myristoyl glycine (By similarity).Swiss-Prot 53.0
3S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
11Phosphoserine.Swiss-Prot 53.0
13Phosphoserine.Swiss-Prot 53.0
397Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
508Phosphotyrosine.Swiss-Prot 53.0
396Phosphotyrosine (Lyn)8530369;17081983Phospho.ELM 6.0
507Phosphotyrosine (Csk)9171348Phospho.ELM 6.0
192Phosphotyrosine16497976Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr8

Promoter: 56953426 - 56955426Agilent_014791

chr8

Promoter: 56953426 - 56955426GoldenGate_Methylation_Cancer_Panel_I

chr8

Promoter: 56953426 - 56955426GSE27584

chr8

Promoter: 56953426 - 56955426Agilent_014791_44K


')