Entrez Gene

Basic Information
Gene ID	4067
Name	LYN

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.790+2T>G; p.?; 8:55953986-55953986	ovary	carcinoma; serous_carcinoma	Unknown
c.884A>G; p.K295R; 8:55966808-55966808	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1480C>A; p.Q494K; 8:56010051-56010051	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.130C>T; p.P44S; 8:55941989-55941989	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1229C>T; p.T410M; 8:55999442-55999442	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1229C>T; p.T410M; 8:55999442-55999442	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.491G>C; p.S164T; 8:55951969-55951969	skin	malignant_melanoma	Substitution - Missense
c.352G>A; p.V118M; 8:55950526-55950526	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.20A>T; p.K7I; 8:55941879-55941879	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.415G>A; p.A139T; 8:55950712-55950712	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.336C>T; p.F112F; 8:55950510-55950510	skin	malignant_melanoma	Substitution - coding silent
c.933G>A; p.R311R; 8:55966857-55966857	skin	malignant_melanoma	Substitution - coding silent
c.450T>C; p.A150A; 8:55950747-55950747	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.27A>T; p.K9N; 8:55941886-55941886	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1522T>C; p.Y508H; 8:56010093-56010093	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.879C>T; p.L293L; 8:55966803-55966803	skin	malignant_melanoma	Substitution - coding silent
c.1408G>C; p.D470H; 8:56009979-56009979	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1517G>A; p.G506E; 8:56010088-56010088	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.689A>G; p.K230R; 8:55953883-55953883	thyroid	carcinoma	Substitution - Missense
c.355G>T; p.A119S; 8:55950529-55950529	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.475G>A; p.E159K; 8:55950772-55950772	breast	carcinoma	Substitution - Missense
c.164G>T; p.R55M; 8:55946479-55946479	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1155T>C; p.D385D; 8:55998450-55998450	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1105C>T; p.R369*; 8:55998400-55998400	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1155T>C; p.D385D; 8:55998450-55998450	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.285G>T; p.E95D; 8:55950459-55950459	skin	malignant_melanoma	Substitution - Missense
c.1212G>C; p.K404N; 8:55999425-55999425	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.621G>A; p.M207I; 8:55952099-55952099	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.785G>A; p.W262*; 8:55953979-55953979	skin	malignant_melanoma	Substitution - Nonsense
c.320C>A; p.T107K; 8:55950494-55950494	skin	malignant_melanoma	Substitution - Missense
c.1068A>T; p.A356A; 8:55998363-55998363	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.196G>T; p.D66Y; 8:55947635-55947635	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1005A>C; p.E335D; 8:55969748-55969748	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.312C>T; p.S104S; 8:55950486-55950486	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1046C>A; p.A349D; 8:55969789-55969789	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1000G>A; p.D334N; 8:55969743-55969743	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.57G>C; p.L19F; 8:55941916-55941916	breast	carcinoma	Substitution - Missense
c.699G>A; p.K233K; 8:55953893-55953893	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1266T>G; p.I422M; 8:55999479-55999479	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.186G>A; p.E62E; 8:55947625-55947625	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.447C>A; p.S149R; 8:55950744-55950744	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.8G>A; p.C3Y; 8:55941867-55941867	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.222T>A; p.Y74*; 8:55947661-55947661	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1153G>T; p.D385Y; 8:55998448-55998448	breast	carcinoma; lobular_carcinoma	Substitution - Missense
c.1153G>T; p.D385Y; 8:55998448-55998448	breast	carcinoma; lobular_carcinoma	Substitution - Missense
c.1104G>A; p.L368L; 8:55998399-55998399	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1527G>A; p.Q509Q; 8:56010098-56010098	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1096C>T; p.R366W; 8:55998391-55998391	breast	carcinoma	Substitution - Missense
c.907G>C; p.V303L; 8:55966831-55966831	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.388T>G; p.F130V; 8:55950685-55950685	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.388T>G; p.F130V; 8:55950685-55950685	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1472A>G; p.D491G; 8:56010043-56010043	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.211T>C; p.L71L; 8:55947650-55947650	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.675T>A; p.A225A; 8:55953869-55953869	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1206T>C; p.G402G; 8:55999419-55999419	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.210C>A; p.A70A; 8:55947649-55947649	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1075G>A; p.E359K; 8:55998370-55998370	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1075G>A; p.E359K; 8:55998370-55998370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.580T>C; p.Y194H; 8:55952058-55952058	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.773T>G; p.F258C; 8:55953967-55953967	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.870A>C; p.E290D; 8:55966794-55966794	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.414C>T; p.D138D; 8:55950711-55950711	pancreas	carcinoma	Substitution - coding silent
c.414C>T; p.D138D; 8:55950711-55950711	pancreas	carcinoma	Substitution - coding silent
c.356C>T; p.A119V; 8:55950530-55950530	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.414C>T; p.D138D; 8:55950711-55950711	pancreas	carcinoma	Substitution - coding silent
c.1408G>T; p.D470Y; 8:56009979-56009979	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.986A>G; p.D329G; 8:55969729-55969729	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1363G>A; p.A455T; 8:56009934-56009934	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1363G>A; p.A455T; 8:56009934-56009934	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1083G>A; p.K361K; 8:55998378-55998378	skin	malignant_melanoma	Substitution - coding silent
c.1070A>G; p.Y357C; 8:55998365-55998365	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.440G>A; p.G147E; 8:55950737-55950737	skin	malignant_melanoma	Substitution - Missense
c.830T>C; p.L277P; 8:55966754-55966754	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.731G>A; p.R244Q; 8:55953925-55953925	urinary_tract; bladder	carcinoma	Substitution - Missense
c.384-1G>T; p.?; 8:55950680-55950680	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1486G>A; p.V496I; 8:56010057-56010057	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.503C>T; p.S168F; 8:55951981-55951981	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1284C>T; p.S428S; 8:55999497-55999497	skin	malignant_melanoma	Substitution - coding silent
c.1390C>T; p.R464C; 8:56009961-56009961	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.766G>C; p.G256R; 8:55953960-55953960	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1105C>G; p.R369G; 8:55998400-55998400	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.627A>T; p.K209N; 8:55952105-55952105	breast	carcinoma	Substitution - Missense
c.1216C>T; p.P406S; 8:55999429-55999429	skin	malignant_melanoma	Substitution - Missense
c.345C>A; p.S115R; 8:55950519-55950519	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.259G>A; p.G87R; 8:55947698-55947698	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1252G>A; p.G418R; 8:55999465-55999465	breast	carcinoma	Substitution - Missense
c.323A>G; p.K108R; 8:55950497-55950497	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1136T>C; p.L379P; 8:55998431-55998431	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.505G>A; p.V169I; 8:55951983-55951983	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.662G>A; p.R221K; 8:55953856-55953856	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.723G>C; p.E241D; 8:55953917-55953917	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.168T>G; p.F56L; 8:55946483-55946483	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.791-1G>T; p.?; 8:55966714-55966714	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.791-1G>T; p.?; 8:55966714-55966714	ovary	other; neoplasm	Unknown
c.179-1G>A; p.?; 8:55947617-55947617	skin	malignant_melanoma	Unknown
c.868G>A; p.E290K; 8:55966792-55966792	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.993G>A; p.L331L; 8:55969736-55969736	skin	malignant_melanoma	Substitution - coding silent
c.1063A>G; p.M355V; 8:55998358-55998358	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1440G>A; p.W480*; 8:56010011-56010011	skin	malignant_melanoma	Substitution - Nonsense
c.321delA; p.E110fs*15; 8:55950495-55950495	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.616G>A; p.D206N; 8:55952094-55952094	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.321delA; p.E110fs*15; 8:55950495-55950495	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.321delA; p.E110fs*15; 8:55950495-55950495	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1535C>T; p.P512L; 8:56010106-56010106	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1478T>C; p.L493S; 8:56010049-56010049	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.678T>C; p.C226C; 8:55953872-55953872	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1327C>T; p.P443S; 8:55999540-55999540	skin	malignant_melanoma	Substitution - Missense
c.1485C>T; p.S495S; 8:56010056-56010056	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1442A>C; p.K481T; 8:56010013-56010013	breast	carcinoma	Substitution - Missense
c.733G>A; p.E245K; 8:55953927-55953927	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1508C>A; p.A503D; 8:56010079-56010079	breast	carcinoma	Substitution - Missense
c.597C>T; p.I199I; 8:55952075-55952075	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.597C>T; p.I199I; 8:55952075-55952075	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.691C>T; p.P231S; 8:55953885-55953885	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database