| General information | Literature | Expression | lncRNA |Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 23327 |
Name | NEDD4L |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription factors [Top] |
The investigation of TF-target regulations in human from AnimalTFDB 3.0 database and hTFtarget |
|---|
| Links to the hTFtarget for NEDD4L |
| Links to the AnimalTFDB for NEDD4L |
Regulation From TransFac database | Nedd4-2(h) + SGK-1(h) <==> Nedd4-2(h):SGK-1(h) (binding) | alphaENaC(h) + Nedd4-2(h) <==> alphaENaC(h):Nedd4-2(h) (binding) | Smad7(m) + Nedd4-2(h) <==> Smad7(m):Nedd4-2(h) (binding) | Nedd4-2(h) + Smad7(m.s.) <==> Nedd4-2(h):Smad7(m.s.) (binding) | Smad6(m.s.) + Nedd4-2(h) <==> Smad6(m.s.):Nedd4-2(h) (binding) | Nedd4-2(h) + Smad2(m.s.) <==> Nedd4-2(h):Smad2(m.s.) (binding) | Smad3(m.s.) + Nedd4-2(h) <==> Smad3(m.s.):Nedd4-2(h) (binding) | Smad1(m.s.) + Nedd4-2(h) <==> Smad1(m.s.):Nedd4-2(h) (binding) | Smad5(m.s.) + Nedd4-2(h) <==> Smad5(m.s.):Nedd4-2(h) (binding) | Smad7(m.s.) + Nedd4-2(h) + TGFbetaR-I(m.s.):TGFbetaR-II(m.s.) <==> Smad7(m.s.):Nedd4-2(h):TGFbetaR-I(m.s.):TGFbetaR-II(m.s.) (binding) | Nedd4-2(h) + Smad2(m.s.) + SnoN(m.s.) <==> Nedd4-2(h):Smad2(m.s.):SnoN(m.s.) (binding) | trkA(r) + Nedd4-2(h) <==> trkA(r):Nedd4-2(h) (binding) | 14-3-3sigma(m.s.) + Nedd4-2(h) <==> 14-3-3sigma(m.s.):Nedd4-2(h) (binding) | NEDD4L(h) --> Nedd4-2(h) (expression). | trkA(r) + ubiquitin(b) --E1(rb),Ubc5B(rb),Nedd4-2(h)--> trkA(r){ub} (ubiquitination) | trkA(r) + ubiquitin(h) --Nedd4-2(h)--> trkA(r){ub} (ubiquitination) | NEDD4L(h) --> Nedd4-2-xbb1(h) (expression). | NEDD4L(h) --> Nedd4-2-isoform4(h) (expression). | NEDD4L(h) --> Nedd4-2-isoform5(h) (expression). | NEDD4L(h) --> Nedd4-2-isoform1(h) (expression). | NEDD4L(h) --> Nedd4-2-isoform6(h) (expression). | NEDD4L(h) --> Nedd4-2-isoform7(h) (expression). |
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 302 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 342 | Phosphoserine (by PKA) (Probable). | Swiss-Prot 53.0 | 367 | Phosphothreonine (by SGK) (Probable). | Swiss-Prot 53.0 | 446 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 448 | Phosphoserine (by PKA and SGK). | Swiss-Prot 53.0 | 479 | Phosphoserine. | Swiss-Prot 53.0 | 483 | Phosphoserine. | Swiss-Prot 53.0 | 487 | Phosphoserine. | Swiss-Prot 53.0 | 449 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 479 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 483 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 487 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr18 |
Promoter: 53861278 - 53863278 | Agilent_014791 |
chr18 |
Promoter: 53861278 - 53863278 | GSE27584 |
chr18 |
Promoter: 53861278 - 53863278 | Agilent_014791_44K |