Entrez Gene

Basic Information
Gene ID	23327
Name	NEDD4L

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.704A>T; p.N235I; 18:58329018-58329018	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2683G>A; p.E895K; 18:58390733-58390733	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.530T>A; p.V177D; 18:58325012-58325012	skin	malignant_melanoma	Substitution - Missense
c.2320G>A; p.G774R; 18:58383273-58383273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.329T>A; p.V110E; 18:58316013-58316013	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2118C>G; p.L706L; 18:58367860-58367860	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.2624G>A; p.R875H; 18:58390674-58390674	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2624G>A; p.R875H; 18:58390674-58390674	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2624G>A; p.R875H; 18:58390674-58390674	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2786C>A; p.P929H; 18:58396187-58396187	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2099C>T; p.A700V; 18:58367841-58367841	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2614G>A; p.A872T; 18:58390664-58390664	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.474T>C; p.G158G; 18:58323295-58323295	thyroid	other; neoplasm	Substitution - coding silent
c.294A>G; p.R98R; 18:58252051-58252051	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.570_572delTCC; p.P194delP; 18:58325052-58325054	oesophagus	carcinoma; adenocarcinoma	Deletion - In frame
c.1774-2A>G; p.?; 18:58365997-58365997	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1880G>C; p.R627T; 18:58366105-58366105	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2416G>A; p.A806T; 18:58385575-58385575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.91G>A; p.D31N; 18:58165830-58165830	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.689C>T; p.S230F; 18:58329003-58329003	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1703G>T; p.G568V; 18:58357248-58357248	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.571C>T; p.P191S; 18:58325053-58325053	skin	malignant_melanoma	Substitution - Missense
c.758G>T; p.R253M; 18:58329072-58329072	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.498G>A; p.Q166Q; 18:58323319-58323319	breast	carcinoma	Substitution - coding silent
c.2404A>G; p.K802E; 18:58385563-58385563	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2788C>G; p.P930A; 18:58396189-58396189	breast	carcinoma	Substitution - Missense
c.1617C>T; p.H539H; 18:58351014-58351014	breast	carcinoma	Substitution - coding silent
c.1943T>A; p.F648Y; 18:58366168-58366168	breast	carcinoma	Substitution - Missense
c.52G>C; p.E18Q; 18:58165791-58165791	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.52G>C; p.E18Q; 18:58165791-58165791	breast	carcinoma	Substitution - Missense
c.616T>A; p.L206I; 18:58325098-58325098	liver	carcinoma	Substitution - Missense
c.1216T>C; p.S406P; 18:58341696-58341696	skin	malignant_melanoma	Substitution - Missense
c.692C>T; p.S231L; 18:58329006-58329006	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1025G>T; p.S342I; 18:58333852-58333852	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2509G>T; p.D837Y; 18:58389106-58389106	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.786G>A; p.E262E; 18:58329100-58329100	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.384T>C; p.F128F; 18:58322460-58322460	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1342C>G; p.R448G; 18:58342930-58342930	breast	carcinoma	Substitution - Missense
c.1816A>C; p.N606H; 18:58366041-58366041	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.60T>C; p.R20R; 18:58165799-58165799	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1955C>A; p.S652Y; 18:58366180-58366180	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.2655A>C; p.T885T; 18:58390705-58390705	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.204+2T>C; p.?; 18:58245510-58245510	ovary	other; neoplasm	Unknown
c.2540C>T; p.S847F; 18:58389137-58389137	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.742C>T; p.R248C; 18:58329056-58329056	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1924G>T; p.G642C; 18:58366149-58366149	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1019C>A; p.S340*; 18:58333846-58333846	thyroid	other; neoplasm	Substitution - Nonsense
c.371G>A; p.R124Q; 18:58322447-58322447	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1404_1405insC; p.K469fs*29; 18:58342992-58342993	prostate	carcinoma	Insertion - Frameshift
c.1980C>T; p.Y660Y; 18:58366205-58366205	pancreas	carcinoma	Substitution - coding silent
c.1980C>T; p.Y660Y; 18:58366205-58366205	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1138C>T; p.R380C; 18:58341110-58341110	oesophagus	carcinoma	Substitution - Missense
c.1138C>T; p.R380C; 18:58341110-58341110	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1138C>T; p.R380C; 18:58341110-58341110	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1138C>T; p.R380C; 18:58341110-58341110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1138C>T; p.R380C; 18:58341110-58341110	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.97G>A; p.A33T; 18:58165836-58165836	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.97G>A; p.A33T; 18:58165836-58165836	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.594G>A; p.G198G; 18:58325076-58325076	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1302A>G; p.L434L; 18:58341782-58341782	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.546G>A; p.S182S; 18:58325028-58325028	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.269T>A; p.L90Q; 18:58252026-58252026	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.830C>T; p.S277L; 18:58330754-58330754	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2263T>C; p.F755L; 18:58373240-58373240	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.431G>C; p.G144A; 18:58323252-58323252	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.651G>A; p.R217R; 18:58325133-58325133	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1026T>C; p.S342S; 18:58333853-58333853	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.58C>T; p.R20C; 18:58165797-58165797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.439C>T; p.R147*; 18:58323260-58323260	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2835G>A; p.V945V; 18:58396236-58396236	skin	malignant_melanoma	Substitution - coding silent
c.768C>A; p.S256R; 18:58329082-58329082	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2061G>A; p.L687L; 18:58367803-58367803	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.116G>T; p.G39V; 18:58165855-58165855	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1837C>T; p.R613W; 18:58366062-58366062	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.696G>A; p.E232E; 18:58329010-58329010	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.1883_1884delTG; p.W629fs*2; 18:58366108-58366109	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.2500G>A; p.G834S; 18:58389097-58389097	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2500G>A; p.G834S; 18:58389097-58389097	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1029C>G; p.V343V; 18:58333856-58333856	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.613A>G; p.N205D; 18:58325095-58325095	liver	carcinoma	Substitution - Missense
c.96C>T; p.L32L; 18:58165835-58165835	prostate	carcinoma	Substitution - coding silent
c.1838G>A; p.R613Q; 18:58366063-58366063	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2100C>T; p.A700A; 18:58367842-58367842	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.517G>A; p.G173R; 18:58324999-58324999	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2352_2353delAA; p.R785fs*33; 18:58383305-58383306	prostate	carcinoma	Deletion - Frameshift
c.2499C>T; p.C833C; 18:58389096-58389096	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1470C>T; p.N490N; 18:58343058-58343058	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2569C>T; p.H857Y; 18:58389166-58389166	skin	malignant_melanoma	Substitution - Missense
c.1025G>A; p.S342N; 18:58333852-58333852	liver	carcinoma	Substitution - Missense
c.347C>T; p.P116L; 18:58316031-58316031	lung	carcinoid-endocrine_tumour; typical	Substitution - Missense
c.347C>T; p.P116L; 18:58316031-58316031	prostate	carcinoma	Substitution - Missense
c.2799C>A; p.T933T; 18:58396200-58396200	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2207A>G; p.Y736C; 18:58373184-58373184	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.896G>T; p.G299V; 18:58330820-58330820	thyroid	carcinoma	Substitution - Missense
c.2207A>G; p.Y736C; 18:58373184-58373184	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1629A>G; p.R543R; 18:58351026-58351026	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1342C>T; p.R448W; 18:58342930-58342930	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.694G>A; p.E232K; 18:58329008-58329008	skin	malignant_melanoma	Substitution - Missense
c.2464A>C; p.I822L; 18:58387475-58387475	breast	carcinoma	Substitution - Missense
c.1897G>A; p.E633K; 18:58366122-58366122	urinary_tract; bladder	carcinoma	Substitution - Missense
c.620G>A; p.G207D; 18:58325102-58325102	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1648+10C>T; p.?; 18:58351055-58351055	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.229G>C; p.E77Q; 18:58248923-58248923	breast	carcinoma	Substitution - Missense
c.312C>T; p.F104F; 18:58315996-58315996	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1154A>G; p.N385S; 18:58341126-58341126	central_nervous_system; brain	glioma	Substitution - Missense
c.1828G>C; p.E610Q; 18:58366053-58366053	liver	carcinoma	Substitution - Missense
c.1962G>T; p.E654D; 18:58366187-58366187	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2613C>T; p.D871D; 18:58390663-58390663	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1165C>T; p.R389*; 18:58341137-58341137	skin	malignant_melanoma	Substitution - Nonsense
c.1165C>T; p.R389*; 18:58341137-58341137	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.748C>T; p.R250C; 18:58329062-58329062	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.792G>A; p.S264S; 18:58329106-58329106	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1774-1G>A; p.?; 18:58365998-58365998	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1812A>T; p.R604S; 18:58366037-58366037	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.748C>T; p.R250C; 18:58329062-58329062	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1340G>A; p.R447H; 18:58342928-58342928	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.86G>T; p.G29V; 18:58165825-58165825	liver	carcinoma	Substitution - Missense
c.757A>T; p.R253W; 18:58329071-58329071	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.86G>T; p.G29V; 18:58165825-58165825	liver	carcinoma	Substitution - Missense
c.1519G>T; p.D507Y; 18:58349540-58349540	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.701A>G; p.D234G; 18:58329015-58329015	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1921delG; p.G642fs*66; 18:58366146-58366146	oesophagus	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.188C>A; p.T63K; 18:58245492-58245492	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.623G>A; p.R208Q; 18:58325105-58325105	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1887G>A; p.W629*; 18:58366112-58366112	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2617G>A; p.E873K; 18:58390667-58390667	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.591C>A; p.P197P; 18:58325073-58325073	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.569T>C; p.L190P; 18:58325051-58325051	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.343C>T; p.L115F; 18:58316027-58316027	skin	malignant_melanoma	Substitution - Missense
c.2347A>G; p.N783D; 18:58383300-58383300	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1918T>A; p.Y640N; 18:58366143-58366143	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.539A>G; p.N180S; 18:58325021-58325021	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2452G>A; p.D818N; 18:58387463-58387463	skin	malignant_melanoma	Substitution - Missense
c.589C>T; p.P197S; 18:58325071-58325071	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.39C>T; p.S13S; 18:58044699-58044699	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1179G>C; p.W393C; 18:58341151-58341151	ovary	other; neoplasm	Substitution - Missense
c.193A>G; p.T65A; 18:58245497-58245497	central_nervous_system; brain	glioma	Substitution - Missense
c.784G>A; p.E262K; 18:58329098-58329098	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.784G>A; p.E262K; 18:58329098-58329098	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2364C>T; p.I788I; 18:58383317-58383317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.769G>A; p.E257K; 18:58329083-58329083	adrenal_gland; adrenal_gland	adrenal_cortical_adenoma; cortisol_producing	Substitution - Missense
c.2701G>C; p.G901R; 18:58391495-58391495	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2364C>T; p.I788I; 18:58383317-58383317	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.769G>A; p.E257K; 18:58329083-58329083	ovary	other; neoplasm	Substitution - Missense
c.784G>A; p.E262K; 18:58329098-58329098	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.532G>C; p.D178H; 18:58325014-58325014	breast	carcinoma	Substitution - Missense
c.285C>T; p.D95D; 18:58252042-58252042	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.835G>A; p.E279K; 18:58330759-58330759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1033G>A; p.D345N; 18:58333860-58333860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1033G>A; p.D345N; 18:58333860-58333860	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Substitution - Missense

The somatic mutations from COSMIC database