Entrez Gene

Basic Information
Gene ID	9126
Name	SMC3

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.481G>A; p.E161K; 10:110580955-110580955	breast	carcinoma	Substitution - Missense
c.2030A>G; p.E677G; 10:110596464-110596464	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1258T>G; p.L420V; 10:110584349-110584349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1258T>G; p.L420V; 10:110584349-110584349	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2135A>G; p.D712G; 10:110598157-110598157	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.612G>T; p.E204D; 10:110581987-110581987	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.944A>G; p.E315G; 10:110583523-110583523	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.625G>A; p.E209K; 10:110582000-110582000	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2830C>T; p.R944*; 10:110601822-110601822	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2830C>T; p.R944*; 10:110601822-110601822	skin	malignant_melanoma	Substitution - Nonsense
c.2965C>T; p.Q989*; 10:110602038-110602038	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2830C>T; p.R944*; 10:110601822-110601822	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3442G>A; p.A1148T; 10:110602969-110602969	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1916C>T; p.S639L; 10:110593176-110593176	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.295C>T; p.R99*; 10:110577859-110577859	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.295C>T; p.R99*; 10:110577859-110577859	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1402G>T; p.E468*; 10:110589701-110589701	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1028A>T; p.E343V; 10:110583899-110583899	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2093delA; p.N699fs*16; 10:110596527-110596527	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.3519T>C; p.T1173T; 10:110603227-110603227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.395G>A; p.R132Q; 10:110578672-110578672	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.66C>G; p.P22P; 10:110568988-110568988	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2044G>A; p.V682I; 10:110596478-110596478	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.273C>T; p.I91I; 10:110577837-110577837	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.970-1G>C; p.?; 10:110583840-110583840	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Unknown
c.1142G>T; p.R381L; 10:110584233-110584233	urinary_tract; bladder	carcinoma	Substitution - Missense
c.163C>T; p.H55Y; 10:110575368-110575368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.970-1G>C; p.?; 10:110583840-110583840	urinary_tract; bladder	carcinoma	Unknown
c.3001A>G; p.I1001V; 10:110602074-110602074	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.648G>A; p.W216*; 10:110582023-110582023	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemia	Substitution - Nonsense
c.2468G>C; p.G823A; 10:110600479-110600479	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1252A>G; p.K418E; 10:110584343-110584343	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2357delT; p.S787fs*3; 10:110599742-110599742	stomach	carcinoma; diffuse_adenocarcinoma	Deletion - Frameshift
c.274G>A; p.D92N; 10:110577838-110577838	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2045T>C; p.V682A; 10:110596479-110596479	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.290C>T; p.S97L; 10:110577854-110577854	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.290C>T; p.S97L; 10:110577854-110577854	skin	malignant_melanoma	Substitution - Missense
c.430-1G>A; p.?; 10:110580903-110580903	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; mast_cell_neoplasm	Unknown
c.2121delT; p.N708fs*7; 10:110598143-110598143	endometrium	carcinoma; serous_carcinoma	Deletion - Frameshift
c.430-1G>A; p.?; 10:110580903-110580903	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	Unknown
c.1635T>G; p.A545A; 10:110590537-110590537	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2500G>T; p.E834*; 10:110600511-110600511	breast	carcinoma	Substitution - Nonsense
c.1304A>G; p.N435S; 10:110584395-110584395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.131C>T; p.A44V; 10:110575336-110575336	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.859G>T; p.E287*; 10:110583438-110583438	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1269T>G; p.T423T; 10:110584360-110584360	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1269T>G; p.T423T; 10:110584360-110584360	pancreas	carcinoma	Substitution - coding silent
c.1123C>A; p.L375I; 10:110584214-110584214	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1118C>T; p.T373M; 10:110584209-110584209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1118C>T; p.T373M; 10:110584209-110584209	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1825A>G; p.M609V; 10:110593085-110593085	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1642A>G; p.T548A; 10:110590544-110590544	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1710G>A; p.T570T; 10:110591030-110591030	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2775G>A; p.M925I; 10:110601767-110601767	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1710G>A; p.T570T; 10:110591030-110591030	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1410-5A>G; p.?; 10:110589887-110589887	liver	carcinoma	Unknown
c.1410-5A>G; p.?; 10:110589887-110589887	liver	carcinoma	Unknown
c.1710G>A; p.T570T; 10:110591030-110591030	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2685G>A; p.K895K; 10:110601677-110601677	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1568G>A; p.G523E; 10:110590470-110590470	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.462G>C; p.Q154H; 10:110580936-110580936	breast	carcinoma	Substitution - Missense
c.3510T>G; p.F1170L; 10:110603218-110603218	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.488C>G; p.A163G; 10:110580962-110580962	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.371T>G; p.L124R; 10:110578648-110578648	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2749C>T; p.H917Y; 10:110601741-110601741	skin	malignant_melanoma	Substitution - Missense
c.2387G>T; p.R796I; 10:110599772-110599772	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1849C>T; p.P617S; 10:110593109-110593109	skin	malignant_melanoma	Substitution - Missense
c.2783G>A; p.R928Q; 10:110601775-110601775	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2636G>A; p.R879Q; 10:110601122-110601122	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2701A>G; p.M901V; 10:110601693-110601693	breast	carcinoma	Substitution - Missense
c.2216T>C; p.M739T; 10:110598238-110598238	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>C; p.E52Q; 10:110575359-110575359	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1028A>G; p.E343G; 10:110583899-110583899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1028A>G; p.E343G; 10:110583899-110583899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1028A>G; p.E343G; 10:110583899-110583899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2936A>G; p.Y979C; 10:110602009-110602009	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.127T>C; p.Y43H; 10:110573742-110573742	skin	malignant_melanoma	Substitution - Missense
c.2899C>T; p.R967*; 10:110601972-110601972	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1978C>T; p.H660Y; 10:110596412-110596412	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2243A>C; p.Q748P; 10:110598265-110598265	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1239T>C; p.I413I; 10:110584330-110584330	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.607C>G; p.L203V; 10:110581982-110581982	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.214C>T; p.R72C; 10:110577436-110577436	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2686G>A; p.E896K; 10:110601678-110601678	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.111delA; p.S39fs*73; 10:110573726-110573726	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3261C>T; p.V1087V; 10:110602629-110602629	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3070C>T; p.R1024W; 10:110602143-110602143	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1406G>T; p.R469I; 10:110589705-110589705	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3298-2A>G; p.?; 10:110602823-110602823	NS	NS	Unknown
c.3134A>T; p.Q1045L; 10:110602502-110602502	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3134A>T; p.Q1045L; 10:110602502-110602502	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1709C>T; p.T570M; 10:110591029-110591029	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.131-2A>G; p.?; 10:110575334-110575334	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.2878C>T; p.L960L; 10:110601870-110601870	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2707C>T; p.R903C; 10:110601699-110601699	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.313delA; p.K106fs*6; 10:110577877-110577877	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1426G>A; p.E476K; 10:110589908-110589908	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1253A>C; p.K418T; 10:110584344-110584344	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1898G>A; p.C633Y; 10:110593158-110593158	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.740A>G; p.E247G; 10:110582578-110582578	pancreas	carcinoma	Substitution - Missense
c.2070T>C; p.G690G; 10:110596504-110596504	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2626A>C; p.T876P; 10:110601112-110601112	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.526A>C; p.I176L; 10:110581000-110581000	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1942A>G; p.M648V; 10:110593202-110593202	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2757T>C; p.T919T; 10:110601749-110601749	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1142G>A; p.R381Q; 10:110584233-110584233	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1397A>C; p.Q466P; 10:110589696-110589696	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1756A>G; p.T586A; 10:110591076-110591076	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1756A>G; p.T586A; 10:110591076-110591076	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1756A>G; p.T586A; 10:110591076-110591076	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.187G>A; p.A63T; 10:110575392-110575392	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2288T>C; p.L763S; 10:110599673-110599673	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1984G>T; p.G662C; 10:110596418-110596418	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1984G>T; p.G662C; 10:110596418-110596418	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1984G>T; p.G662C; 10:110596418-110596418	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - Missense
c.429G>A; p.K143K; 10:110578706-110578706	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1984G>T; p.G662C; 10:110596418-110596418	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2192C>G; p.S731C; 10:110598214-110598214	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.629T>C; p.L210P; 10:110582004-110582004	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.629T>C; p.L210P; 10:110582004-110582004	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3558C>A; p.F1186L; 10:110603266-110603266	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.540A>T; p.K180N; 10:110581014-110581014	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3043A>G; p.M1015V; 10:110602116-110602116	liver	carcinoma	Substitution - Missense
c.392C>A; p.S131Y; 10:110578669-110578669	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3278T>G; p.F1093C; 10:110602646-110602646	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3067C>T; p.L1023F; 10:110602140-110602140	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2632G>T; p.A878S; 10:110601118-110601118	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2470A>T; p.I824F; 10:110600481-110600481	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.361G>A; p.V121M; 10:110578638-110578638	liver	carcinoma	Substitution - Missense
c.1236G>T; p.Q412H; 10:110584327-110584327	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.62A>T; p.D21V; 10:110568984-110568984	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.688C>G; p.Q230E; 10:110582063-110582063	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2453G>T; p.R818I; 10:110600464-110600464	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.688C>G; p.Q230E; 10:110582063-110582063	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3608C>A; p.A1203E; 10:110604256-110604256	central_nervous_system; thalamus	glioma; astrocytoma_Grade_II	Substitution - Missense
c.3612G>C; p.E1204D; 10:110604260-110604260	breast	carcinoma	Substitution - Missense
c.2923G>A; p.E975K; 10:110601996-110601996	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.869A>G; p.Q290R; 10:110583448-110583448	parathyroid	adenoma	Substitution - Missense
c.1979A>G; p.H660R; 10:110596413-110596413	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.759C>T; p.S253S; 10:110582597-110582597	skin	malignant_melanoma	Substitution - coding silent
c.3191G>A; p.G1064D; 10:110602559-110602559	breast	carcinoma	Substitution - Missense
c.1929C>T; p.A643A; 10:110593189-110593189	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.956A>G; p.N319S; 10:110583535-110583535	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.273C>G; p.I91M; 10:110577837-110577837	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.121delT; p.Y43fs*69; 10:110573736-110573736	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.121delT; p.Y43fs*69; 10:110573736-110573736	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.121delT; p.Y43fs*69; 10:110573736-110573736	stomach	adenocarcinoma	Deletion - Frameshift
c.2425C>T; p.Q809*; 10:110599810-110599810	large_intestine; colon	carcinoma	Substitution - Nonsense
c.2644+2T>C; p.?; 10:110601132-110601132	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.2425C>T; p.Q809*; 10:110599810-110599810	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1182G>T; p.W394C; 10:110584273-110584273	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2709C>T; p.R903R; 10:110601701-110601701	skin; leg	malignant_melanoma; superficial_spreading	Substitution - coding silent
c.2926T>A; p.L976I; 10:110601999-110601999	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.271-4T>A; p.?; 10:110577831-110577831	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.1852A>T; p.R618*; 10:110593112-110593112	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1203_1205delTTT; p.L402delL; 10:110584294-110584296	breast	carcinoma; basal_(triple-negative)_carcinoma	Deletion - In frame
c.2042A>T; p.D681V; 10:110596476-110596476	skin	malignant_melanoma	Substitution - Missense
c.760A>T; p.R254*; 10:110582598-110582598	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Nonsense
c.61G>C; p.D21H; 10:110568983-110568983	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2479C>T; p.R827*; 10:110600490-110600490	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.168delT; p.R57fs*55; 10:110575373-110575373	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3521C>T; p.T1174I; 10:110603229-110603229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.72T>C; p.S24S; 10:110568994-110568994	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2000G>A; p.G667D; 10:110596434-110596434	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.72T>C; p.S24S; 10:110568994-110568994	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.133A>G; p.I45V; 10:110575338-110575338	thyroid	carcinoma	Substitution - Missense
c.845C>G; p.S282*; 10:110583424-110583424	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.845C>G; p.S282*; 10:110583424-110583424	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.2603C>A; p.A868D; 10:110601089-110601089	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.649G>A; p.D217N; 10:110582024-110582024	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.649G>A; p.D217N; 10:110582024-110582024	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.16-1G>T; p.?; 10:110568937-110568937	lung; right_lower_lobe	carcinoma; adenocarcinoma	Unknown
c.1758delT; p.L588fs*6; 10:110591078-110591078	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1937T>A; p.F646Y; 10:110593197-110593197	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1981C>T; p.R661W; 10:110596415-110596415	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1981C>T; p.R661W; 10:110596415-110596415	skin	malignant_melanoma	Substitution - Missense
c.2344G>T; p.G782*; 10:110599729-110599729	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1789G>C; p.D597H; 10:110591109-110591109	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3443C>T; p.A1148V; 10:110602970-110602970	breast	carcinoma	Substitution - Missense
c.1901G>A; p.R634H; 10:110593161-110593161	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3622G>A; p.D1208N; 10:110604270-110604270	skin	malignant_melanoma	Substitution - Missense
c.2029G>A; p.E677K; 10:110596463-110596463	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2005T>G; p.Y669D; 10:110596439-110596439	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.312_313insA; p.D107fs*14; 10:110577876-110577877	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1029A>G; p.E343E; 10:110583900-110583900	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2900G>A; p.R967Q; 10:110601973-110601973	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database