Entrez Gene

Basic Information
Gene ID	8650
Name	NUMB

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1942G>C; p.E648Q; 14:73276592-73276592	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1077A>G; p.P359P; 14:73282378-73282378	skin	malignant_melanoma	Substitution - coding silent
c.20G>A; p.S7N; 14:73355732-73355732	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1745A>G; p.H582R; 14:73276789-73276789	skin	malignant_melanoma	Substitution - Missense
c.410G>A; p.R137H; 14:73292774-73292774	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.235-5A>T; p.?; 14:73297290-73297290	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.235-5A>T; p.?; 14:73297290-73297290	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.918G>A; p.Q306Q; 14:73284112-73284112	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.586C>G; p.R196G; 14:73287179-73287179	skin	malignant_melanoma	Substitution - Missense
c.1721C>T; p.P574L; 14:73276813-73276813	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1559C>A; p.P520Q; 14:73276975-73276975	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1402C>T; p.Q468*; 14:73277132-73277132	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1781A>T; p.D594V; 14:73276753-73276753	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1351G>A; p.V451I; 14:73277183-73277183	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.561C>A; p.T187T; 14:73287204-73287204	breast	carcinoma	Substitution - coding silent
c.590T>C; p.V197A; 14:73287175-73287175	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.433A>G; p.M145V; 14:73292751-73292751	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1862C>T; p.A621V; 14:73276672-73276672	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1811C>T; p.T604I; 14:73276723-73276723	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1784G>A; p.G595D; 14:73276750-73276750	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.534G>A; p.V178V; 14:73287231-73287231	skin	malignant_melanoma	Substitution - coding silent
c.98G>C; p.R33P; 14:73355654-73355654	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.354C>T; p.A118A; 14:73292830-73292830	skin	malignant_melanoma	Substitution - coding silent
c.218A>G; p.K73R; 14:73316406-73316406	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1187C>T; p.P396L; 14:73279334-73279334	skin	malignant_melanoma	Substitution - Missense
c.1284C>T; p.L428L; 14:73277250-73277250	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1732C>T; p.P578S; 14:73276802-73276802	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.772C>T; p.P258S; 14:73284258-73284258	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1917C>T; p.F639F; 14:73276617-73276617	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.443A>G; p.K148R; 14:73292741-73292741	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.190delA; p.R64fs*2; 14:73323141-73323141	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.889C>A; p.R297S; 14:73284141-73284141	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1943A>C; p.E648A; 14:73276591-73276591	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.310-2A>G; p.?; 14:73292876-73292876	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.919A>T; p.R307W; 14:73284111-73284111	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.630G>T; p.M210I; 14:73287135-73287135	central_nervous_system; brain	glioma; astrocytoma_Grade_III	Substitution - Missense
c.1813G>A; p.E605K; 14:73276721-73276721	breast	carcinoma	Substitution - Missense
c.842C>A; p.P281H; 14:73284188-73284188	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1857G>A; p.Q619Q; 14:73276677-73276677	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.140T>C; p.V47A; 14:73323191-73323191	liver	carcinoma	Substitution - Missense
c.601A>T; p.T201S; 14:73287164-73287164	breast	carcinoma	Substitution - Missense
c.783C>T; p.I261I; 14:73284247-73284247	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1810A>G; p.T604A; 14:73276724-73276724	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1810A>G; p.T604A; 14:73276724-73276724	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1128T>C; p.L376L; 14:73279393-73279393	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.706G>A; p.A236T; 14:73284324-73284324	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1047G>A; p.P349P; 14:73282408-73282408	pancreas	carcinoma	Substitution - coding silent
c.1047G>A; p.P349P; 14:73282408-73282408	breast	carcinoma	Substitution - coding silent
c.587G>C; p.R196P; 14:73287178-73287178	urinary_tract; bladder	carcinoma	Substitution - Missense
c.981C>G; p.I327M; 14:73282474-73282474	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.944delA; p.N315fs*6; 14:73284086-73284086	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1175G>A; p.R392H; 14:73279346-73279346	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1889G>A; p.R630H; 14:73276645-73276645	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.649A>G; p.K217E; 14:73287116-73287116	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1825G>T; p.G609C; 14:73276709-73276709	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.841C>T; p.P281S; 14:73284189-73284189	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1558C>T; p.P520S; 14:73276976-73276976	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1805G>T; p.R602M; 14:73276729-73276729	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.88G>T; p.E30*; 14:73355664-73355664	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.243G>T; p.K81N; 14:73297277-73297277	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1159G>A; p.V387I; 14:73279362-73279362	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1457C>T; p.A486V; 14:73277077-73277077	breast	carcinoma	Substitution - Missense
c.1554C>A; p.P518P; 14:73276980-73276980	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.202-1G>A; p.?; 14:73316423-73316423	skin	malignant_melanoma	Unknown
c.808C>G; p.Q270E; 14:73284222-73284222	skin	malignant_melanoma	Substitution - Missense
c.229G>A; p.G77R; 14:73316395-73316395	skin	malignant_melanoma	Substitution - Missense
c.595A>C; p.T199P; 14:73287170-73287170	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1938G>A; p.T646T; 14:73276596-73276596	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1938G>A; p.T646T; 14:73276596-73276596	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1174C>T; p.R392C; 14:73279347-73279347	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1174C>T; p.R392C; 14:73279347-73279347	breast	carcinoma	Substitution - Missense
c.1812A>G; p.T604T; 14:73276722-73276722	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1360C>T; p.Q454*; 14:73277174-73277174	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1778A>C; p.D593A; 14:73276756-73276756	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.857_859delAGA; p.K286delK; 14:73284171-73284173	breast	carcinoma; basal_(triple-negative)_carcinoma	Deletion - In frame
c.704C>T; p.T235I; 14:73284326-73284326	skin	malignant_melanoma	Substitution - Missense
c.587G>A; p.R196H; 14:73287178-73287178	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.49C>G; p.P17A; 14:73355703-73355703	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.972_975delAGAG; p.E325fs*25; 14:73282480-73282483	ovary	carcinoma	Deletion - Frameshift
c.874C>T; p.R292C; 14:73284156-73284156	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1599G>A; p.Q533Q; 14:73276935-73276935	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.220G>T; p.G74C; 14:73316404-73316404	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1769A>G; p.N590S; 14:73276765-73276765	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.477C>T; p.G159G; 14:73287288-73287288	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1353C>G; p.V451V; 14:73277181-73277181	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1876A>C; p.K626Q; 14:73276658-73276658	breast	carcinoma	Substitution - Missense
c.154T>C; p.S52P; 14:73323177-73323177	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.102C>T; p.T34T; 14:73355650-73355650	skin	malignant_melanoma	Substitution - coding silent
c.981C>T; p.I327I; 14:73282474-73282474	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.981C>T; p.I327I; 14:73282474-73282474	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.899A>G; p.E300G; 14:73284131-73284131	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1A>G; p.M1V; 14:73355751-73355751	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.49C>T; p.P17S; 14:73355703-73355703	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.49C>T; p.P17S; 14:73355703-73355703	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1213A>G; p.N405D; 14:73279308-73279308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.98G>A; p.R33H; 14:73355654-73355654	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.98G>A; p.R33H; 14:73355654-73355654	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database