Entrez Gene

Basic Information
Gene ID	6493
Name	SIM2

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1015G>A; p.E339K; 21:36743403-36743403	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.938T>C; p.V313A; 21:36741804-36741804	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.534C>T; p.S178S; 21:36723121-36723121	breast	carcinoma	Substitution - coding silent
c.277T>G; p.F93V; 21:36712551-36712551	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.137C>A; p.T46N; 21:36699883-36699883	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1234C>T; p.P412S; 21:36744794-36744794	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.632T>G; p.V211G; 21:36726207-36726207	breast	carcinoma	Substitution - Missense
c.932C>T; p.A311V; 21:36741798-36741798	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.201G>A; p.P67P; 21:36709193-36709193	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.592A>T; p.M198L; 21:36726167-36726167	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.168C>G; p.F56L; 21:36699914-36699914	liver	carcinoma	Substitution - Missense
c.168C>G; p.F56L; 21:36699914-36699914	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1348G>A; p.D450N; 21:36744908-36744908	skin	malignant_melanoma	Substitution - Missense
c.228C>T; p.V76V; 21:36709220-36709220	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.758C>T; p.T253M; 21:36731059-36731059	breast	carcinoma	Substitution - Missense
c.604G>A; p.D202N; 21:36726179-36726179	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1179G>A; p.S393S; 21:36744739-36744739	thyroid	other; neoplasm	Substitution - coding silent
c.1406A>C; p.Q469P; 21:36744966-36744966	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1558C>T; p.L520L; 21:36745118-36745118	skin	malignant_melanoma	Substitution - coding silent
c.1167+8G>A; p.?; 21:36743563-36743563	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.516C>T; p.N172N; 21:36723103-36723103	breast	carcinoma	Substitution - coding silent
c.627G>A; p.G209G; 21:36726202-36726202	skin	malignant_melanoma	Substitution - coding silent
c.1158delC; p.P388fs*93; 21:36743546-36743546	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1576+2T>G; p.?; 21:36745138-36745138	breast	carcinoma	Unknown
c.906C>T; p.G302G; 21:36741772-36741772	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.487C>T; p.R163*; 21:36723074-36723074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.487C>T; p.R163*; 21:36723074-36723074	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.487C>T; p.R163*; 21:36723074-36723074	breast	carcinoma	Substitution - Nonsense
c.1064C>T; p.S355F; 21:36743452-36743452	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.549C>T; p.I183I; 21:36726124-36726124	skin	malignant_melanoma	Substitution - coding silent
c.1569C>T; p.S523S; 21:36745129-36745129	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.651G>A; p.L217L; 21:36726226-36726226	central_nervous_system; brain	glioma	Substitution - coding silent
c.668C>T; p.T223I; 21:36726243-36726243	skin	malignant_melanoma	Substitution - Missense
c.635C>T; p.A212V; 21:36726210-36726210	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.130C>G; p.R44G; 21:36699876-36699876	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.580T>C; p.Y194H; 21:36726155-36726155	skin	malignant_melanoma	Substitution - Missense
c.81C>A; p.L27L; 21:36699827-36699827	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.188C>T; p.A63V; 21:36709180-36709180	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.188C>T; p.A63V; 21:36709180-36709180	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1361T>C; p.F454S; 21:36744921-36744921	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1342C>T; p.P448S; 21:36744902-36744902	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1447C>A; p.L483M; 21:36745007-36745007	thyroid	other; neoplasm	Substitution - Missense
c.315C>T; p.S105S; 21:36712589-36712589	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.448C>A; p.L150M; 21:36719920-36719920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.321C>T; p.T107T; 21:36712595-36712595	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.743+9G>A; p.?; 21:36726327-36726327	pancreas	carcinoma	Unknown
c.159C>T; p.R53R; 21:36699905-36699905	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.570G>T; p.K190N; 21:36726145-36726145	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1098T>A; p.T366T; 21:36743486-36743486	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1098T>A; p.T366T; 21:36743486-36743486	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.513G>A; p.R171R; 21:36723100-36723100	skin	malignant_melanoma	Substitution - coding silent
c.812G>A; p.G271D; 21:36731113-36731113	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.214C>T; p.P72S; 21:36709206-36709206	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.336A>G; p.L112L; 21:36712610-36712610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.861G>A; p.K287K; 21:36741727-36741727	skin	malignant_melanoma	Substitution - coding silent
c.384C>T; p.I128I; 21:36719856-36719856	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.400G>A; p.D134N; 21:36719872-36719872	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.953G>A; p.R318H; 21:36741819-36741819	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.953G>A; p.R318H; 21:36741819-36741819	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.661G>A; p.A221T; 21:36726236-36726236	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1465T>G; p.C489G; 21:36745025-36745025	fallopian_tube	carcinoma; serous_carcinoma	Substitution - Missense
c.735G>A; p.L245L; 21:36726310-36726310	skin	malignant_melanoma	Substitution - coding silent
c.1028C>A; p.S343Y; 21:36743416-36743416	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.271T>A; p.F91I; 21:36712545-36712545	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.679C>T; p.L227L; 21:36726254-36726254	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1101G>A; p.R367R; 21:36743489-36743489	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.54C>A; p.G18G; 21:36699800-36699800	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.608C>A; p.S203Y; 21:36726183-36726183	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.477G>A; p.S159S; 21:36723064-36723064	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.784G>A; p.E262K; 21:36731085-36731085	skin	malignant_melanoma	Substitution - Missense
c.642C>T; p.G214G; 21:36726217-36726217	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1033G>A; p.E345K; 21:36743421-36743421	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.662C>T; p.A221V; 21:36726237-36726237	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.736G>A; p.D246N; 21:36726311-36726311	skin	malignant_melanoma	Substitution - Missense
c.999G>A; p.T333T; 21:36743387-36743387	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.492G>A; p.M164I; 21:36723079-36723079	skin	malignant_melanoma	Substitution - Missense
c.829C>T; p.L277F; 21:36731130-36731130	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.817G>A; p.D273N; 21:36731118-36731118	skin	malignant_melanoma	Substitution - Missense
c.892C>T; p.L298L; 21:36741758-36741758	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.457+1G>T; p.?; 21:36719930-36719930	autonomic_ganglia	neuroblastoma	Unknown
c.1044C>A; p.S348S; 21:36743432-36743432	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1074C>T; p.T358T; 21:36743462-36743462	liver	carcinoma	Substitution - coding silent
c.1074C>T; p.T358T; 21:36743462-36743462	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1074C>T; p.T358T; 21:36743462-36743462	liver	carcinoma	Substitution - coding silent
c.799C>T; p.H267Y; 21:36731100-36731100	skin	malignant_melanoma	Substitution - Missense
c.359C>T; p.T120M; 21:36719831-36719831	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.624G>T; p.V208V; 21:36726199-36726199	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.417C>T; p.V139V; 21:36719889-36719889	large_intestine; rectum	NS	Substitution - coding silent
c.119C>T; p.A40V; 21:36699865-36699865	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1425G>A; p.V475V; 21:36744985-36744985	prostate	carcinoma	Substitution - coding silent
c.1354C>G; p.H452D; 21:36744914-36744914	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.596C>A; p.S199Y; 21:36726171-36726171	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1467C>T; p.C489C; 21:36745027-36745027	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1242C>T; p.S414S; 21:36744802-36744802	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.505G>A; p.A169T; 21:36723092-36723092	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.783C>T; p.I261I; 21:36731084-36731084	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

The somatic mutations from COSMIC database