Entrez Gene

Basic Information
Gene ID	5743
Name	PTGS2

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.522C>T; p.I174I; 1:186677766-186677766	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.267T>A; p.N89K; 1:186679104-186679104	liver	carcinoma	Substitution - Missense
c.1496G>T; p.R499L; 1:186674672-186674672	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1748C>A; p.S583Y; 1:186674420-186674420	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.245A>G; p.K82R; 1:186679126-186679126	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1548C>T; p.S516S; 1:186674620-186674620	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.89G>A; p.G30D; 1:186679402-186679402	skin	malignant_melanoma	Substitution - Missense
c.1258-2A>G; p.?; 1:186675398-186675398	lung	carcinoma; small_cell_carcinoma	Unknown
c.465G>T; p.K155N; 1:186677823-186677823	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1358G>A; p.R453H; 1:186675296-186675296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.112G>A; p.D38N; 1:186679379-186679379	breast	carcinoma	Substitution - Missense
c.600T>A; p.H200Q; 1:186677688-186677688	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.848G>A; p.G283D; 1:186676589-186676589	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.522C>A; p.I174I; 1:186677766-186677766	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1357C>A; p.R453S; 1:186675297-186675297	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1456G>T; p.A486S; 1:186674712-186674712	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.63C>A; p.C21*; 1:186679428-186679428	breast	carcinoma	Substitution - Nonsense
c.347A>G; p.Y116C; 1:186678371-186678371	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.898G>A; p.D300N; 1:186676539-186676539	breast	carcinoma	Substitution - Missense
c.126C>T; p.C42C; 1:186679365-186679365	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.126C>T; p.C42C; 1:186679365-186679365	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.216C>A; p.N72K; 1:186679155-186679155	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1228G>A; p.E410K; 1:186675927-186675927	skin	malignant_melanoma	Substitution - Missense
c.745C>T; p.P249S; 1:186676692-186676692	skin	malignant_melanoma	Substitution - Missense
c.284G>A; p.R95Q; 1:186679087-186679087	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.284G>A; p.R95Q; 1:186679087-186679087	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.592A>G; p.T198A; 1:186677696-186677696	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1304A>T; p.Q435L; 1:186675350-186675350	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1498C>T; p.P500S; 1:186674670-186674670	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1597C>T; p.P533S; 1:186674571-186674571	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.624C>T; p.N208N; 1:186677664-186677664	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.877C>T; p.R293W; 1:186676560-186676560	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.877C>T; p.R293W; 1:186676560-186676560	central_nervous_system; brain	glioma	Substitution - Missense
c.1005G>A; p.V335V; 1:186676150-186676150	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.279C>T; p.F93F; 1:186679092-186679092	skin	malignant_melanoma	Substitution - coding silent
c.742T>C; p.Y248H; 1:186676695-186676695	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.458-1G>T; p.?; 1:186677831-186677831	lung	carcinoma; adenocarcinoma	Unknown
c.945C>A; p.F315L; 1:186676492-186676492	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1144C>G; p.Q382E; 1:186676011-186676011	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.432T>C; p.D144D; 1:186678286-186678286	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1768G>A; p.D590N; 1:186674400-186674400	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1601G>A; p.S534N; 1:186674567-186674567	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1572T>C; p.V524V; 1:186674596-186674596	central_nervous_system; brain	glioma	Substitution - coding silent
c.1119G>C; p.W373C; 1:186676036-186676036	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1497G>C; p.R499R; 1:186674671-186674671	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1669A>G; p.N557D; 1:186674499-186674499	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.859T>C; p.Y287H; 1:186676578-186676578	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1669A>G; p.N557D; 1:186674499-186674499	liver	carcinoma	Substitution - Missense
c.692G>A; p.R231H; 1:186676864-186676864	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.897C>T; p.C299C; 1:186676540-186676540	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.900T>C; p.D300D; 1:186676537-186676537	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1243C>T; p.Q415*; 1:186675912-186675912	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.171G>A; p.P57P; 1:186679200-186679200	breast	carcinoma	Substitution - coding silent
c.509G>C; p.R170T; 1:186677779-186677779	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.862G>A; p.A288T; 1:186676575-186676575	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.78T>C; p.C26C; 1:186679413-186679413	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.580C>T; p.Q194*; 1:186677708-186677708	breast	carcinoma	Substitution - Nonsense
c.151G>A; p.G51R; 1:186679340-186679340	skin	malignant_melanoma	Substitution - Missense
c.720T>A; p.Y240*; 1:186676836-186676836	liver	carcinoma	Substitution - Nonsense
c.720T>A; p.Y240*; 1:186676836-186676836	liver	carcinoma	Substitution - Nonsense
c.207C>T; p.P69P; 1:186679164-186679164	breast	carcinoma	Substitution - coding silent
c.1495C>T; p.R499W; 1:186674673-186674673	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1388C>T; p.S463L; 1:186675266-186675266	skin	malignant_melanoma	Substitution - Missense
c.135C>A; p.T45T; 1:186679356-186679356	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1200G>A; p.L400L; 1:186675955-186675955	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.297G>A; p.M99I; 1:186679074-186679074	breast	carcinoma	Substitution - Missense
c.137G>T; p.R46L; 1:186679354-186679354	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1377G>A; p.K459K; 1:186675277-186675277	breast	carcinoma	Substitution - coding silent
c.356A>G; p.D119G; 1:186678362-186678362	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.333C>A; p.D111E; 1:186678385-186678385	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.847G>A; p.G283S; 1:186676590-186676590	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1193C>T; p.S398F; 1:186675962-186675962	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1035G>A; p.L345L; 1:186676120-186676120	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.878G>T; p.R293L; 1:186676559-186676559	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.694C>A; p.L232I; 1:186676862-186676862	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.878G>A; p.R293Q; 1:186676559-186676559	skin	malignant_melanoma	Substitution - Missense
c.493G>A; p.E165K; 1:186677795-186677795	skin	malignant_melanoma	Substitution - Missense
c.1632C>T; p.I544I; 1:186674536-186674536	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.99G>A; p.M33I; 1:186679392-186679392	skin	malignant_melanoma	Substitution - Missense
c.1625T>G; p.F542C; 1:186674543-186674543	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.396C>T; p.S132S; 1:186678322-186678322	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1435G>T; p.A479S; 1:186674733-186674733	pancreas	carcinoma	Substitution - Missense
c.1435G>T; p.A479S; 1:186674733-186674733	pancreas	carcinoma	Substitution - Missense
c.1435G>T; p.A479S; 1:186674733-186674733	pancreas	carcinoma	Substitution - Missense
c.691C>T; p.R231C; 1:186676865-186676865	pancreas	carcinoma	Substitution - Missense
c.1754G>A; p.R585H; 1:186674414-186674414	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.338C>T; p.P113L; 1:186678380-186678380	skin	malignant_melanoma	Substitution - Missense
c.1135G>A; p.D379N; 1:186676020-186676020	skin; trunk	malignant_melanoma	Substitution - Missense
c.1617A>C; p.E539D; 1:186674551-186674551	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1406-2A>G; p.?; 1:186674764-186674764	breast	carcinoma	Unknown
c.1492C>G; p.P498A; 1:186674676-186674676	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1802C>A; p.S601*; 1:186674366-186674366	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1072C>T; p.Q358*; 1:186676083-186676083	liver	carcinoma	Substitution - Nonsense
c.946C>T; p.Q316*; 1:186676491-186676491	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1009C>T; p.H337Y; 1:186676146-186676146	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1020C>A; p.G340G; 1:186676135-186676135	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.409G>T; p.A137S; 1:186678309-186678309	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.464A>C; p.K155T; 1:186677824-186677824	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.528T>A; p.D176E; 1:186677760-186677760	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1593G>T; p.W531C; 1:186674575-186674575	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.320C>T; p.S107L; 1:186678398-186678398	skin	malignant_melanoma	Substitution - Missense
c.1045C>A; p.P349T; 1:186676110-186676110	liver	carcinoma	Substitution - Missense
c.1045C>A; p.P349T; 1:186676110-186676110	liver	carcinoma	Substitution - Missense
c.519C>T; p.F173F; 1:186677769-186677769	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.136C>T; p.R46W; 1:186679355-186679355	pancreas	carcinoma	Substitution - Missense
c.660C>T; p.Y220Y; 1:186676896-186676896	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.634C>T; p.H212Y; 1:186677654-186677654	skin	malignant_melanoma	Substitution - Missense
c.266A>G; p.N89S; 1:186679105-186679105	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.266A>G; p.N89S; 1:186679105-186679105	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1655C>A; p.S552Y; 1:186674513-186674513	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1279C>T; p.P427S; 1:186675375-186675375	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1802C>T; p.S601L; 1:186674366-186674366	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.529C>T; p.P177S; 1:186677759-186677759	skin	malignant_melanoma	Substitution - Missense
c.1802C>T; p.S601L; 1:186674366-186674366	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.167C>A; p.T56K; 1:186679324-186679324	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1802C>T; p.S601L; 1:186674366-186674366	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.808C>T; p.R270W; 1:186676629-186676629	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.366C>A; p.Y122*; 1:186678352-186678352	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.772G>A; p.E258K; 1:186676665-186676665	skin	malignant_melanoma	Substitution - Missense
c.283C>T; p.R95*; 1:186679088-186679088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1738A>G; p.N580D; 1:186674430-186674430	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1486G>A; p.E496K; 1:186674682-186674682	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.661G>T; p.G221C; 1:186676895-186676895	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>T; p.G203V; 1:186677680-186677680	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1281A>G; p.P427P; 1:186675373-186675373	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1272G>T; p.R424S; 1:186675382-186675382	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.1272G>T; p.R424S; 1:186675382-186675382	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.683G>A; p.R228H; 1:186676873-186676873	breast	carcinoma	Substitution - Missense
c.1577G>A; p.C526Y; 1:186674591-186674591	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.683G>A; p.R228H; 1:186676873-186676873	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1677G>A; p.K559K; 1:186674491-186674491	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1358G>T; p.R453L; 1:186675296-186675296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.404C>T; p.T135I; 1:186678314-186678314	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1491G>T; p.K497N; 1:186674677-186674677	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.115C>A; p.Q39K; 1:186679376-186679376	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1799G>A; p.R600H; 1:186674369-186674369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1799G>A; p.R600H; 1:186674369-186674369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.927G>A; p.W309*; 1:186676510-186676510	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.927G>A; p.W309*; 1:186676510-186676510	skin	malignant_melanoma	Substitution - Nonsense
c.682C>A; p.R228S; 1:186676874-186676874	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.438G>A; p.P146P; 1:186678280-186678280	skin	malignant_melanoma	Substitution - coding silent
c.738G>T; p.E246D; 1:186676699-186676699	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.291A>C; p.A97A; 1:186679080-186679080	pancreas	carcinoma	Substitution - coding silent
c.1185C>A; p.Y395*; 1:186675970-186675970	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.291A>C; p.A97A; 1:186679080-186679080	pancreas	carcinoma	Substitution - coding silent
c.291A>C; p.A97A; 1:186679080-186679080	pancreas	carcinoma	Substitution - coding silent
c.291A>C; p.A97A; 1:186679080-186679080	pancreas	carcinoma	Substitution - coding silent
c.291A>C; p.A97A; 1:186679080-186679080	pancreas	carcinoma	Substitution - coding silent
c.1759G>A; p.G587R; 1:186674409-186674409	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.755delT; p.V252fs*8; 1:186676682-186676682	liver	carcinoma	Deletion - Frameshift
c.172G>A; p.E58K; 1:186679199-186679199	skin	malignant_melanoma	Substitution - Missense
c.477T>A; p.D159E; 1:186677811-186677811	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1001A>G; p.Y334C; 1:186676154-186676154	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense

The somatic mutations from COSMIC database