Entrez Gene

Basic Information
Gene ID	4691
Name	NCL

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.600C>T; p.D200D; 2:231461553-231461553	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1405C>G; p.Q469E; 2:231457685-231457685	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2063G>A; p.G688E; 2:231455261-231455261	breast	carcinoma	Substitution - Missense
c.387C>A; p.I129I; 2:231461766-231461766	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.783_785delTGA; p.D261delD; 2:231460695-231460697	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - In frame
c.783_785delTGA; p.D261delD; 2:231460695-231460697	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - In frame
c.1851C>A; p.F617L; 2:231455606-231455606	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1851C>A; p.F617L; 2:231455606-231455606	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.135+5T>C; p.?; 2:231463195-231463195	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1896C>T; p.D632D; 2:231455561-231455561	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.877G>A; p.A293T; 2:231460499-231460499	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.139G>A; p.V47I; 2:231462014-231462014	skin	malignant_melanoma	Substitution - Missense
c.1113C>A; p.V371V; 2:231459053-231459053	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.615C>A; p.D205E; 2:231460865-231460865	large_intestine; colon	NS	Substitution - Missense
c.750C>A; p.D250E; 2:231460730-231460730	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.828A>G; p.A276A; 2:231460548-231460548	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.771_785del15; p.D257_D261delDDEDD; 2:231460695-231460709	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.925C>A; p.L309I; 2:231460267-231460267	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.427G>A; p.E143K; 2:231461726-231461726	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1196A>G; p.N399S; 2:231458359-231458359	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.927C>T; p.L309L; 2:231460265-231460265	skin; arm	malignant_melanoma	Substitution - coding silent
c.1606G>A; p.A536T; 2:231456730-231456730	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.777A>T; p.E259D; 2:231460703-231460703	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.777A>T; p.E259D; 2:231460703-231460703	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.568G>A; p.E190K; 2:231461585-231461585	skin; scalp	malignant_melanoma	Substitution - Missense
c.866C>T; p.A289V; 2:231460510-231460510	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1851C>T; p.F617F; 2:231455606-231455606	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1851C>T; p.F617F; 2:231455606-231455606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1851C>T; p.F617F; 2:231455606-231455606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.774_776delTGA; p.D258delD; 2:231460704-231460706	skin	malignant_melanoma	Deletion - In frame
c.765T>A; p.D255E; 2:231460715-231460715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>T; p.A174A; 2:231461631-231461631	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.774_776delTGA; p.D258delD; 2:231460704-231460706	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - In frame
c.774_776delTGA; p.D258delD; 2:231460704-231460706	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - In frame
c.774_776delTGA; p.D258delD; 2:231460704-231460706	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - In frame
c.1363G>A; p.D455N; 2:231457727-231457727	prostate	carcinoma	Substitution - Missense
c.765T>A; p.D255E; 2:231460715-231460715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1113C>T; p.V371V; 2:231459053-231459053	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.271G>A; p.A91T; 2:231461882-231461882	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.365C>T; p.P122L; 2:231461788-231461788	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.480C>T; p.D160D; 2:231461673-231461673	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.486_491delCGAGGA; p.D168_E169delDE; 2:231461662-231461667	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1511A>C; p.E504A; 2:231457061-231457061	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.810_811insGGA; p.E270_E271insG; 2:231460669-231460670	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - In frame
c.810_811insGGA; p.E270_E271insG; 2:231460669-231460670	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Insertion - In frame
c.576C>T; p.D192D; 2:231461577-231461577	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.874G>A; p.E292K; 2:231460502-231460502	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1959C>T; p.F653F; 2:231455498-231455498	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.581A>G; p.D194G; 2:231461572-231461572	breast	carcinoma	Substitution - Missense
c.630T>A; p.A210A; 2:231460850-231460850	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.762A>T; p.E254D; 2:231460718-231460718	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.762A>T; p.E254D; 2:231460718-231460718	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1617T>C; p.A539A; 2:231456719-231456719	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1481delC; p.Y495fs*34; 2:231457091-231457091	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1621A>C; p.N541H; 2:231456715-231456715	pancreas	NS	Substitution - Missense
c.1955G>T; p.G652V; 2:231455502-231455502	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1108A>C; p.K370Q; 2:231459058-231459058	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1079T>C; p.L360P; 2:231459087-231459087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1811G>A; p.R604Q; 2:231456031-231456031	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.78_80delAGA; p.E26delE; 2:231463255-231463257	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.533C>A; p.A178E; 2:231461620-231461620	prostate	adenoma	Substitution - Missense
c.2036G>A; p.R679K; 2:231455421-231455421	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1934C>T; p.A645V; 2:231455523-231455523	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1706-10_1706-9insT; p.?; 2:231456145-231456146	pancreas	carcinoma; adenocarcinoma	Unknown
c.76G>T; p.E26*; 2:231463259-231463259	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1133T>A; p.L378Q; 2:231459033-231459033	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.194T>C; p.V65A; 2:231461959-231461959	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1366_1367GG>TT; p.G456L; 2:231457723-231457724	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.916G>A; p.A306T; 2:231460276-231460276	skin	malignant_melanoma	Substitution - Missense
c.916G>A; p.A306T; 2:231460276-231460276	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.723T>G; p.D241E; 2:231460757-231460757	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1010C>T; p.A337V; 2:231460182-231460182	prostate	carcinoma	Substitution - Missense
c.181G>T; p.A61S; 2:231461972-231461972	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1705C>T; p.Q569*; 2:231456631-231456631	stomach	adenocarcinoma	Substitution - Nonsense
c.2060G>A; p.R687Q; 2:231455264-231455264	liver	carcinoma	Substitution - Missense
c.106G>A; p.D36N; 2:231463229-231463229	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1850T>C; p.F617S; 2:231455607-231455607	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>A; p.A174A; 2:231461631-231461631	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1364A>T; p.D455V; 2:231457726-231457726	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.496G>A; p.D166N; 2:231461657-231461657	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1785C>T; p.S595S; 2:231456057-231456057	liver	carcinoma	Substitution - coding silent
c.114_116delAGA; p.E38delE; 2:231463219-231463221	oesophagus	carcinoma; adenocarcinoma	Deletion - In frame
c.1785C>T; p.S595S; 2:231456057-231456057	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1689A>C; p.S563S; 2:231456647-231456647	breast	carcinoma	Substitution - coding silent
c.1890G>T; p.M630I; 2:231455567-231455567	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.2077G>C; p.G693R; 2:231455247-231455247	skin; leg	malignant_melanoma	Substitution - Missense
c.637A>T; p.T213S; 2:231460843-231460843	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1201C>T; p.P401S; 2:231458354-231458354	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.448G>C; p.D150H; 2:231461705-231461705	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.451G>A; p.D151N; 2:231461702-231461702	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.2093_2094insAGG; p.G698_D699insG; 2:231455230-231455231	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - In frame
c.1035G>T; p.M345I; 2:231460157-231460157	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1689A>G; p.S563S; 2:231456647-231456647	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.368G>C; p.G123A; 2:231461785-231461785	breast	carcinoma	Substitution - Missense
c.1718C>A; p.T573N; 2:231456124-231456124	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.824A>T; p.E275V; 2:231460552-231460552	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1001A>G; p.N334S; 2:231460191-231460191	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1575T>G; p.Y525*; 2:231456761-231456761	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1088C>T; p.A363V; 2:231459078-231459078	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1482delC; p.Y495fs*34; 2:231457090-231457090	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1712C>T; p.S571F; 2:231456130-231456130	skin	malignant_melanoma	Substitution - Missense
c.363_364TC>AC; p.T121>?; 2:231461789-231461790	lung	carcinoma; adenocarcinoma	Complex
c.1555A>G; p.N519D; 2:231457017-231457017	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1962G>T; p.G654G; 2:231455495-231455495	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1443G>C; p.W481C; 2:231457647-231457647	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1789C>T; p.R597W; 2:231456053-231456053	breast	carcinoma	Substitution - Missense
c.278C>A; p.P93H; 2:231461875-231461875	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.230C>T; p.P77L; 2:231461923-231461923	skin	malignant_melanoma	Substitution - Missense
c.230C>T; p.P77L; 2:231461923-231461923	thyroid	carcinoma	Substitution - Missense
c.1599C>T; p.F533F; 2:231456737-231456737	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1599C>T; p.F533F; 2:231456737-231456737	skin	malignant_melanoma	Substitution - coding silent
c.2018G>A; p.R673Q; 2:231455439-231455439	oesophagus	carcinoma	Substitution - Missense
c.499G>A; p.E167K; 2:231461654-231461654	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.447G>A; p.E149E; 2:231461706-231461706	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.447G>A; p.E149E; 2:231461706-231461706	thyroid	other; neoplasm	Substitution - coding silent
c.848A>G; p.E283G; 2:231460528-231460528	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.848A>G; p.E283G; 2:231460528-231460528	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.577G>A; p.E193K; 2:231461576-231461576	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1713C>T; p.S571S; 2:231456129-231456129	skin	malignant_melanoma	Substitution - coding silent
c.727G>T; p.E243*; 2:231460753-231460753	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.303C>A; p.A101A; 2:231461850-231461850	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2021G>T; p.G674V; 2:231455436-231455436	breast	carcinoma	Substitution - Missense
c.453T>C; p.D151D; 2:231461700-231461700	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.741C>T; p.D247D; 2:231460739-231460739	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.53C>A; p.A18D; 2:231463282-231463282	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.741C>T; p.D247D; 2:231460739-231460739	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1033A>G; p.M345V; 2:231460159-231460159	liver	carcinoma	Substitution - Missense
c.1033A>G; p.M345V; 2:231460159-231460159	liver	carcinoma	Substitution - Missense
c.630T>C; p.A210A; 2:231460850-231460850	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.728A>G; p.E243G; 2:231460752-231460752	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1849T>C; p.F617L; 2:231455608-231455608	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.871C>G; p.P291A; 2:231460505-231460505	breast	carcinoma	Substitution - Missense
c.909G>A; p.P303P; 2:231460283-231460283	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1849T>C; p.F617L; 2:231455608-231455608	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.746A>G; p.D249G; 2:231460734-231460734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.511G>A; p.E171K; 2:231461642-231461642	breast	carcinoma	Substitution - Missense

The somatic mutations from COSMIC database