Entrez Gene

Basic Information
Gene ID	4323
Name	MMP14

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.848A>G; p.Y283C; 14:22843416-22843416	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.907_908CC>TT; p.P303F; 14:22843766-22843767	skin	malignant_melanoma	Substitution - Missense
c.754G>T; p.D252Y; 14:22843322-22843322	urinary_tract; bladder	carcinoma	Substitution - Missense
c.869C>T; p.P290L; 14:22843728-22843728	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1532G>A; p.G511E; 14:22845822-22845822	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1371A>G; p.E457E; 14:22845320-22845320	breast	carcinoma	Substitution - coding silent
c.384C>T; p.I128I; 14:22842413-22842413	skin	malignant_melanoma	Substitution - coding silent
c.717C>T; p.H239H; 14:22843285-22843285	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1410C>T; p.S470S; 14:22845359-22845359	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1381G>C; p.E461Q; 14:22845330-22845330	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.545C>T; p.A182V; 14:22842574-22842574	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.889C>T; p.P297S; 14:22843748-22843748	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1179G>A; p.A393A; 14:22844658-22844658	prostate	adenoma	Substitution - coding silent
c.889C>T; p.P297S; 14:22843748-22843748	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1263_1274del12; p.W421_G425>*; 14:22844742-22844753	prostate	carcinoma	Complex - deletion inframe
c.926C>T; p.P309L; 14:22843785-22843785	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1664T>C; p.V555A; 14:22845954-22845954	skin	malignant_melanoma	Substitution - Missense
c.446G>A; p.R149H; 14:22842475-22842475	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.5C>A; p.S2Y; 14:22836822-22836822	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.142G>T; p.G48W; 14:22841524-22841524	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.654C>T; p.A218A; 14:22842683-22842683	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.779T>A; p.F260Y; 14:22843347-22843347	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1117G>A; p.E373K; 14:22844476-22844476	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; polycythaemia_vera	Substitution - Missense
c.1585G>A; p.V529M; 14:22845875-22845875	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.777C>G; p.P259P; 14:22843345-22843345	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.130T>C; p.Y44H; 14:22841512-22841512	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1369G>A; p.E457K; 14:22845318-22845318	breast	carcinoma	Substitution - Missense
c.616G>T; p.G206C; 14:22842645-22842645	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.778T>C; p.F260L; 14:22843346-22843346	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1309C>T; p.R437C; 14:22845258-22845258	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1607C>T; p.A536V; 14:22845897-22845897	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1607C>T; p.A536V; 14:22845897-22845897	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1291C>T; p.R431C; 14:22844770-22844770	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.317A>G; p.N106S; 14:22841972-22841972	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1063A>G; p.M355V; 14:22844422-22844422	pancreas	carcinoma	Substitution - Missense
c.549G>A; p.E183E; 14:22842578-22842578	skin	malignant_melanoma	Substitution - coding silent
c.1137C>T; p.F379F; 14:22844496-22844496	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1137C>T; p.F379F; 14:22844496-22844496	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1137C>T; p.F379F; 14:22844496-22844496	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.790A>G; p.M264V; 14:22843358-22843358	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.441G>A; p.A147A; 14:22842470-22842470	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.585G>T; p.E195D; 14:22842614-22842614	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.207G>T; p.Q69H; 14:22841589-22841589	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.184T>G; p.S62A; 14:22841566-22841566	oesophagus	carcinoma	Substitution - Missense
c.22C>T; p.P8S; 14:22836839-22836839	breast	carcinoma	Substitution - Missense
c.22C>T; p.P8S; 14:22836839-22836839	thyroid	other; neoplasm	Substitution - Missense
c.22C>T; p.P8S; 14:22836839-22836839	breast	carcinoma	Substitution - Missense
c.559G>A; p.G187S; 14:22842588-22842588	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.339C>T; p.A113A; 14:22841994-22841994	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1529C>T; p.S510L; 14:22845819-22845819	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1526C>T; p.P509L; 14:22845816-22845816	skin	malignant_melanoma	Substitution - Missense
c.1222C>T; p.R408*; 14:22844701-22844701	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.679G>A; p.D227N; 14:22842708-22842708	breast	carcinoma	Substitution - Missense
c.1457T>C; p.F486S; 14:22845747-22845747	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1590C>T; p.D530D; 14:22845880-22845880	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.54C>T; p.L18L; 14:22836871-22836871	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.468A>T; p.P156P; 14:22842497-22842497	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1636G>A; p.V546M; 14:22845926-22845926	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1005C>T; p.V335V; 14:22843864-22843864	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.24C>G; p.P8P; 14:22836841-22836841	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.833G>A; p.G278D; 14:22843401-22843401	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.833G>A; p.G278D; 14:22843401-22843401	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.257+1G>T; p.?; 14:22841640-22841640	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.491A>G; p.Y164C; 14:22842520-22842520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.772G>T; p.A258S; 14:22843340-22843340	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.433C>T; p.R145C; 14:22842462-22842462	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.777C>T; p.P259P; 14:22843345-22843345	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1695T>A; p.H565Q; 14:22845985-22845985	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.817G>A; p.D273N; 14:22843385-22843385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.8C>T; p.P3L; 14:22836825-22836825	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1439G>A; p.G480E; 14:22845729-22845729	skin	malignant_melanoma	Substitution - Missense
c.384C>G; p.I128M; 14:22842413-22842413	breast	carcinoma	Substitution - Missense
c.267G>A; p.R89R; 14:22841922-22841922	ovary	other; neoplasm	Substitution - coding silent
c.1094C>G; p.P365R; 14:22844453-22844453	skin	malignant_melanoma	Substitution - Missense
c.1599C>T; p.G533G; 14:22845889-22845889	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1599C>T; p.G533G; 14:22845889-22845889	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1034G>T; p.R345M; 14:22844393-22844393	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.479G>A; p.R160H; 14:22842508-22842508	breast	carcinoma	Substitution - Missense
c.364A>C; p.N122H; 14:22842019-22842019	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.75C>T; p.L25L; 14:22836892-22836892	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1317C>T; p.N439N; 14:22845266-22845266	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1317C>T; p.N439N; 14:22845266-22845266	liver	carcinoma	Substitution - coding silent
c.547G>A; p.E183K; 14:22842576-22842576	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1318G>A; p.E440K; 14:22845267-22845267	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1318G>A; p.E440K; 14:22845267-22845267	urinary_tract; bladder	carcinoma	Substitution - Missense
c.526G>A; p.D176N; 14:22842555-22842555	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1237G>A; p.D413N; 14:22844716-22844716	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1482A>C; p.E494D; 14:22845772-22845772	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1328G>A; p.R443K; 14:22845277-22845277	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.514G>C; p.E172Q; 14:22842543-22842543	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1036A>G; p.N346D; 14:22844395-22844395	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.741C>T; p.L247L; 14:22843309-22843309	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.960C>T; p.D320D; 14:22843819-22843819	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1261T>C; p.W421R; 14:22844740-22844740	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database