Entrez Gene

Basic Information
Gene ID	3273
Name	HRG

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.541G>C; p.E181Q; 3:186671772-186671772	breast	carcinoma	Substitution - Missense
c.809G>A; p.R270H; 3:186677114-186677114	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.768G>A; p.P256P; 3:186677073-186677073	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.427G>A; p.V143I; 3:186671658-186671658	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1019A>G; p.H340R; 3:186677324-186677324	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1019A>G; p.H340R; 3:186677324-186677324	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1019A>G; p.H340R; 3:186677324-186677324	prostate	adenoma	Substitution - Missense
c.1019A>G; p.H340R; 3:186677324-186677324	thyroid	other; neoplasm	Substitution - Missense
c.1099C>T; p.H367Y; 3:186677404-186677404	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.898C>T; p.P300S; 3:186677203-186677203	skin	malignant_melanoma	Substitution - Missense
c.249G>A; p.R83R; 3:186669000-186669000	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1062T>C; p.H354H; 3:186677367-186677367	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.930C>A; p.P310P; 3:186677235-186677235	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.610C>T; p.P204S; 3:186672838-186672838	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.610C>T; p.P204S; 3:186672838-186672838	prostate	adenoma	Substitution - Missense
c.610C>T; p.P204S; 3:186672838-186672838	thyroid	other; neoplasm	Substitution - Missense
c.289C>T; p.P97S; 3:186669040-186669040	liver	carcinoma	Substitution - Missense
c.289C>T; p.P97S; 3:186669040-186669040	liver	carcinoma	Substitution - Missense
c.781C>A; p.H261N; 3:186677086-186677086	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.781C>A; p.H261N; 3:186677086-186677086	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.48G>A; p.S16S; 3:186666079-186666079	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.48G>A; p.S16S; 3:186666079-186666079	central_nervous_system; brain	glioma	Substitution - coding silent
c.642C>G; p.V214V; 3:186675091-186675091	ovary	other; neoplasm	Substitution - coding silent
c.1063C>A; p.H355N; 3:186677368-186677368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1047C>T; p.L349L; 3:186677352-186677352	skin	malignant_melanoma	Substitution - coding silent
c.410A>G; p.N137S; 3:186671641-186671641	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1573A>T; p.K525*; 3:186677878-186677878	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.866C>T; p.P289L; 3:186677171-186677171	skin	malignant_melanoma	Substitution - Missense
c.702G>A; p.P234P; 3:186675151-186675151	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.702G>A; p.P234P; 3:186675151-186675151	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.137A>T; p.Y46F; 3:186666168-186666168	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1293C>T; p.H431H; 3:186677598-186677598	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.702G>A; p.P234P; 3:186675151-186675151	skin	malignant_melanoma	Substitution - coding silent
c.1262C>T; p.P421L; 3:186677567-186677567	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.646G>A; p.G216R; 3:186675095-186675095	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.683C>T; p.A228V; 3:186675132-186675132	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.484C>A; p.L162I; 3:186671715-186671715	breast	carcinoma	Substitution - Missense
c.568G>A; p.E190K; 3:186672796-186672796	skin	malignant_melanoma	Substitution - Missense
c.1384C>T; p.P462S; 3:186677689-186677689	skin	malignant_melanoma	Substitution - Missense
c.1384C>T; p.P462S; 3:186677689-186677689	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1143C>T; p.P381P; 3:186677448-186677448	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.307G>C; p.G103R; 3:186669944-186669944	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1263C>A; p.P421P; 3:186677568-186677568	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.307G>T; p.G103*; 3:186669944-186669944	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.567G>A; p.G189G; 3:186672795-186672795	skin	malignant_melanoma	Substitution - coding silent
c.862C>T; p.H288Y; 3:186677167-186677167	skin	malignant_melanoma	Substitution - Missense
c.907G>A; p.E303K; 3:186677212-186677212	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.943G>T; p.G315C; 3:186677248-186677248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.862C>T; p.H288Y; 3:186677167-186677167	skin	malignant_melanoma	Substitution - Missense
c.907G>A; p.E303K; 3:186677212-186677212	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.738T>C; p.P246P; 3:186675187-186675187	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.395C>T; p.S132F; 3:186671626-186671626	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.937C>T; p.P313S; 3:186677242-186677242	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.184-5C>T; p.?; 3:186668930-186668930	pancreas	carcinoma	Unknown
c.928C>T; p.P310S; 3:186677233-186677233	skin	malignant_melanoma	Substitution - Missense
c.1480C>T; p.Q494*; 3:186677785-186677785	skin	malignant_melanoma	Substitution - Nonsense
c.1154A>C; p.H385P; 3:186677459-186677459	breast	carcinoma	Substitution - Missense
c.286C>T; p.R96C; 3:186669037-186669037	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.687G>A; p.L229L; 3:186675136-186675136	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.411T>C; p.N137N; 3:186671642-186671642	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.545G>C; p.R182T; 3:186671776-186671776	oesophagus	carcinoma	Substitution - Missense
c.441C>A; p.F147L; 3:186671672-186671672	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.441C>A; p.F147L; 3:186671672-186671672	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.451A>G; p.T151A; 3:186671682-186671682	kidney	other; neoplasm	Substitution - Missense
c.984A>G; p.Q328Q; 3:186677289-186677289	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.408C>T; p.A136A; 3:186671639-186671639	skin	malignant_melanoma	Substitution - coding silent
c.301-7C>G; p.?; 3:186669931-186669931	endometrium	carcinoma; serous_carcinoma	Unknown
c.729C>G; p.V243V; 3:186675178-186675178	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.681A>C; p.E227D; 3:186675130-186675130	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.353A>G; p.D118G; 3:186669990-186669990	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.740A>G; p.Q247R; 3:186675189-186675189	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.124C>T; p.R42*; 3:186666155-186666155	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1552delT; p.F519fs*>7; 3:186677857-186677857	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1552delT; p.F519fs*>7; 3:186677857-186677857	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1552delT; p.F519fs*>7; 3:186677857-186677857	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1552delT; p.F519fs*>7; 3:186677857-186677857	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1339C>T; p.P447S; 3:186677644-186677644	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.552A>G; p.A184A; 3:186671783-186671783	liver	carcinoma	Substitution - coding silent
c.237G>A; p.S79S; 3:186668988-186668988	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.237G>A; p.S79S; 3:186668988-186668988	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1276C>T; p.H426Y; 3:186677581-186677581	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1032T>C; p.N344N; 3:186677337-186677337	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.585C>A; p.F195L; 3:186672813-186672813	breast	carcinoma	Substitution - Missense
c.981T>C; p.C327C; 3:186677286-186677286	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1381C>T; p.L461F; 3:186677686-186677686	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.282C>T; p.S94S; 3:186669033-186669033	skin	malignant_melanoma	Substitution - coding silent
c.1262C>G; p.P421R; 3:186677567-186677567	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1294G>A; p.G432S; 3:186677599-186677599	breast	carcinoma	Substitution - Missense
c.409A>G; p.N137D; 3:186671640-186671640	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.880G>A; p.E294K; 3:186677185-186677185	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.194C>A; p.T65N; 3:186668945-186668945	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.880G>A; p.E294K; 3:186677185-186677185	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1120C>T; p.H374Y; 3:186677425-186677425	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.880G>A; p.E294K; 3:186677185-186677185	breast	carcinoma	Substitution - Missense
c.880G>A; p.E294K; 3:186677185-186677185	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.127C>T; p.R43W; 3:186666158-186666158	stomach	adenocarcinoma	Substitution - Missense
c.1011C>A; p.A337A; 3:186677316-186677316	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1223G>A; p.C408Y; 3:186677528-186677528	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1570C>T; p.P524S; 3:186677875-186677875	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.830C>T; p.P277L; 3:186677135-186677135	skin	malignant_melanoma	Substitution - Missense
c.1344T>C; p.R448R; 3:186677649-186677649	breast	carcinoma	Substitution - coding silent
c.893C>A; p.P298Q; 3:186677198-186677198	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.154C>T; p.R52W; 3:186666185-186666185	breast	carcinoma	Substitution - Missense
c.1397A>T; p.K466I; 3:186677702-186677702	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.639+2T>C; p.?; 3:186672869-186672869	ovary	other; neoplasm	Unknown
c.1557T>A; p.F519L; 3:186677862-186677862	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1431T>G; p.F477L; 3:186677736-186677736	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.47C>T; p.S16L; 3:186666078-186666078	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.709C>A; p.L237I; 3:186675158-186675158	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.535C>T; p.R179*; 3:186671766-186671766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.426G>A; p.P142P; 3:186671657-186671657	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.426G>A; p.P142P; 3:186671657-186671657	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.426G>A; p.P142P; 3:186671657-186671657	eye; retina	retinoblastoma	Substitution - coding silent
c.436G>T; p.D146Y; 3:186671667-186671667	urinary_tract; bladder	carcinoma	Substitution - Missense
c.947C>T; p.P316L; 3:186677252-186677252	urinary_tract; bladder	carcinoma	Substitution - Missense
c.911G>T; p.R304I; 3:186677216-186677216	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1321C>T; p.R441*; 3:186677626-186677626	skin	malignant_melanoma	Substitution - Nonsense
c.812C>A; p.S271Y; 3:186677117-186677117	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.539T>C; p.I180T; 3:186671770-186671770	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.536G>A; p.R179Q; 3:186671767-186671767	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1150C>T; p.H384Y; 3:186677455-186677455	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1507T>A; p.S503T; 3:186677812-186677812	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.411T>G; p.N137K; 3:186671642-186671642	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1208G>A; p.G403E; 3:186677513-186677513	skin	malignant_melanoma	Substitution - Missense
c.742G>A; p.E248K; 3:186677047-186677047	skin	malignant_melanoma	Substitution - Missense
c.1373T>C; p.V458A; 3:186677678-186677678	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1373T>C; p.V458A; 3:186677678-186677678	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.880_886delGAACATG; p.E294fs*143; 3:186677185-186677191	liver	carcinoma	Deletion - Frameshift
c.1478A>T; p.N493I; 3:186677783-186677783	thyroid	other; neoplasm	Substitution - Missense
c.601C>T; p.R201W; 3:186672829-186672829	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.601C>T; p.R201W; 3:186672829-186672829	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.772C>T; p.H258Y; 3:186677077-186677077	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.772C>T; p.H258Y; 3:186677077-186677077	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.62C>T; p.P21L; 3:186666093-186666093	skin	malignant_melanoma	Substitution - Missense
c.1343G>A; p.R448H; 3:186677648-186677648	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.708C>T; p.N236N; 3:186675157-186675157	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.514T>G; p.F172V; 3:186671745-186671745	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.597_598delTG; p.V200fs*25; 3:186672825-186672826	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.128G>A; p.R43Q; 3:186666159-186666159	oesophagus	carcinoma	Substitution - Missense
c.1087G>A; p.G363R; 3:186677392-186677392	skin	malignant_melanoma	Substitution - Missense
c.1441C>T; p.P481S; 3:186677746-186677746	skin	malignant_melanoma	Substitution - Missense
c.527G>A; p.R176K; 3:186671758-186671758	skin; extremity	malignant_melanoma	Substitution - Missense
c.887G>A; p.G296E; 3:186677192-186677192	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.155G>A; p.R52Q; 3:186666186-186666186	skin	malignant_melanoma	Substitution - Missense
c.155G>A; p.R52Q; 3:186666186-186666186	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.343G>A; p.E115K; 3:186669980-186669980	skin	malignant_melanoma	Substitution - Missense
c.1204C>T; p.H402Y; 3:186677509-186677509	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1204C>T; p.H402Y; 3:186677509-186677509	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.351G>A; p.Q117Q; 3:186669988-186669988	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.611C>T; p.P204L; 3:186672839-186672839	skin	malignant_melanoma	Substitution - Missense
c.1396A>C; p.K466Q; 3:186677701-186677701	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1372G>A; p.V458M; 3:186677677-186677677	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.950C>A; p.P317H; 3:186677255-186677255	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1432C>T; p.P478S; 3:186677737-186677737	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432C>T; p.P478S; 3:186677737-186677737	skin	malignant_melanoma	Substitution - Missense
c.385A>C; p.S129R; 3:186670022-186670022	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.701C>T; p.P234L; 3:186675150-186675150	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1217C>A; p.P406H; 3:186677522-186677522	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.633C>T; p.H211H; 3:186672861-186672861	skin	malignant_melanoma	Substitution - coding silent
c.785C>A; p.P262H; 3:186677090-186677090	urinary_tract; bladder	carcinoma	Substitution - Missense
c.585C>T; p.F195F; 3:186672813-186672813	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.144C>T; p.F48F; 3:186666175-186666175	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1430T>G; p.F477C; 3:186677735-186677735	skin	malignant_melanoma	Substitution - Missense
c.850A>T; p.R284*; 3:186677155-186677155	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.236C>T; p.S79L; 3:186668987-186668987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.156G>T; p.R52R; 3:186666187-186666187	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.6G>T; p.K2N; 3:186666037-186666037	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

The somatic mutations from COSMIC database