Entrez Gene

Basic Information
Gene ID	102
Name	ADAM10

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
The somatic mutations from COSMIC database
c.1426A>G; p.S476G; 15:58621556-58621556	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.462C>G; p.V154V; 15:58679146-58679146	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.462C>G; p.V154V; 15:58679146-58679146	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.45G>A; p.A15A; 15:58749490-58749490	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.45G>A; p.A15A; 15:58749490-58749490	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.820C>T; p.R274C; 15:58643894-58643894	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1010C>T; p.S337L; 15:58640779-58640779	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1741A>G; p.T581A; 15:58611062-58611062	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.224T>A; p.M75K; 15:58682297-58682297	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1286A>G; p.N429S; 15:58627774-58627774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.362A>G; p.D121G; 15:58679246-58679246	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1122C>T; p.P374P; 15:58633250-58633250	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1169G>T; p.G390V; 15:58633203-58633203	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1001G>A; p.G334E; 15:58640788-58640788	skin	malignant_melanoma	Substitution - Missense
c.1001G>A; p.G334E; 15:58640788-58640788	skin	malignant_melanoma	Substitution - Missense
c.56-5delT; p.?; 15:58717732-58717732	pancreas	carcinoma; acinar_carcinoma	Unknown
c.1118C>A; p.P373H; 15:58633254-58633254	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.56-5delT; p.?; 15:58717732-58717732	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1712T>G; p.I571S; 15:58611091-58611091	breast	carcinoma	Substitution - Missense
c.56-5delT; p.?; 15:58717732-58717732	pancreas	carcinoma; acinar_carcinoma	Unknown
c.221G>A; p.R74Q; 15:58682300-58682300	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.810C>A; p.F270L; 15:58643904-58643904	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.127C>T; p.H43Y; 15:58717656-58717656	skin	malignant_melanoma	Substitution - Missense
c.1441G>A; p.D481N; 15:58621541-58621541	urinary_tract; bladder	carcinoma	Substitution - Missense
c.293A>T; p.D98V; 15:58682228-58682228	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1441G>A; p.D481N; 15:58621541-58621541	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.402A>G; p.T134T; 15:58679206-58679206	liver	carcinoma	Substitution - coding silent
c.2152G>T; p.G718C; 15:58599598-58599598	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.402A>G; p.T134T; 15:58679206-58679206	liver	carcinoma	Substitution - coding silent
c.295A>G; p.T99A; 15:58682226-58682226	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1742C>T; p.T581M; 15:58611061-58611061	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1579G>A; p.D527N; 15:58611924-58611924	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1145C>T; p.A382V; 15:58633227-58633227	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.292G>C; p.D98H; 15:58682229-58682229	breast	carcinoma	Substitution - Missense
c.1889C>T; p.S630F; 15:58610433-58610433	skin	malignant_melanoma	Substitution - Missense
c.1271G>T; p.G424V; 15:58627789-58627789	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1625T>C; p.L542P; 15:58611878-58611878	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.978C>T; p.G326G; 15:58640811-58640811	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1499G>A; p.G500E; 15:58621483-58621483	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.629G>A; p.R210K; 15:58646161-58646161	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.530C>G; p.S177*; 15:58665152-58665152	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.736-9_736-8insT; p.?; 15:58643986-58643987	stomach	adenocarcinoma	Unknown
c.1297T>G; p.S433A; 15:58627763-58627763	prostate	carcinoma	Substitution - Missense
c.674A>T; p.Y225F; 15:58646116-58646116	skin	malignant_melanoma	Substitution - Missense
c.1931G>A; p.R644Q; 15:58610391-58610391	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.466T>G; p.Y156D; 15:58679142-58679142	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.466T>G; p.Y156D; 15:58679142-58679142	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.326-4A>G; p.?; 15:58679286-58679286	liver	carcinoma	Unknown
c.1754C>T; p.S585F; 15:58611049-58611049	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1754C>T; p.S585F; 15:58611049-58611049	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1270G>T; p.G424W; 15:58627790-58627790	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1207G>A; p.E403K; 15:58627853-58627853	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1773A>G; p.K591K; 15:58611030-58611030	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2165G>C; p.R722T; 15:58597629-58597629	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1681G>A; p.V561M; 15:58611822-58611822	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.492C>T; p.P164P; 15:58665190-58665190	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1161T>G; p.H387Q; 15:58633211-58633211	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1161T>G; p.H387Q; 15:58633211-58633211	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.716G>A; p.R239Q; 15:58646074-58646074	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.716G>A; p.R239Q; 15:58646074-58646074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1510A>G; p.S504G; 15:58621472-58621472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1155T>C; p.V385V; 15:58633217-58633217	liver	carcinoma	Substitution - coding silent
c.1892delC; p.P631fs*17; 15:58610430-58610430	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1898A>G; p.N633S; 15:58610424-58610424	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2166G>A; p.R722R; 15:58597628-58597628	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1000G>A; p.G334R; 15:58640789-58640789	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2207G>T; p.R736L; 15:58597587-58597587	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.696C>A; p.F232L; 15:58646094-58646094	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.304A>C; p.I102L; 15:58682217-58682217	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1166T>G; p.F389C; 15:58633206-58633206	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.423G>C; p.E141D; 15:58679185-58679185	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.869T>C; p.F290S; 15:58640920-58640920	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.501C>T; p.Y167Y; 15:58665181-58665181	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.666T>C; p.C222C; 15:58646124-58646124	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.556C>T; p.Q186*; 15:58665126-58665126	skin	malignant_melanoma	Substitution - Nonsense
c.1192G>C; p.E398Q; 15:58627868-58627868	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.199C>A; p.H67N; 15:58717584-58717584	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1768G>C; p.D590H; 15:58611035-58611035	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1768G>C; p.D590H; 15:58611035-58611035	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.71C>T; p.P24L; 15:58717712-58717712	skin	malignant_melanoma	Substitution - Missense
c.1900G>T; p.D634Y; 15:58610422-58610422	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.430A>G; p.I144V; 15:58679178-58679178	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.526C>T; p.H176Y; 15:58665156-58665156	skin; neck	malignant_melanoma	Substitution - Missense
c.1425T>A; p.Y475*; 15:58621557-58621557	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1171T>C; p.S391P; 15:58633201-58633201	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1425T>A; p.Y475*; 15:58621557-58621557	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.1079C>T; p.T360I; 15:58633293-58633293	skin	malignant_melanoma	Substitution - Missense
c.896A>T; p.K299M; 15:58640893-58640893	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1047C>A; p.L349L; 15:58633325-58633325	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1025G>A; p.G342E; 15:58633347-58633347	central_nervous_system; brain	glioma	Substitution - Missense
c.80A>C; p.K27T; 15:58717703-58717703	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.224T>C; p.M75T; 15:58682297-58682297	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1109C>G; p.S370C; 15:58633263-58633263	thyroid	other; neoplasm	Substitution - Missense
c.333A>C; p.E111D; 15:58679275-58679275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1149C>T; p.H383H; 15:58633223-58633223	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1149C>T; p.H383H; 15:58633223-58633223	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.100G>A; p.G34R; 15:58717683-58717683	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1722A>G; p.K574K; 15:58611081-58611081	liver	carcinoma	Substitution - coding silent
c.1722A>G; p.K574K; 15:58611081-58611081	liver	carcinoma	Substitution - coding silent
c.1722A>G; p.K574K; 15:58611081-58611081	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.790G>A; p.G264R; 15:58643924-58643924	skin; upper_back	malignant_melanoma	Substitution - Missense
c.1686C>T; p.C562C; 15:58611817-58611817	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1473G>T; p.E491D; 15:58621509-58621509	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.795C>T; p.I265I; 15:58643919-58643919	skin	malignant_melanoma	Substitution - coding silent
c.2142A>C; p.K714N; 15:58599608-58599608	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.883A>G; p.I295V; 15:58640906-58640906	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1108T>A; p.S370T; 15:58633264-58633264	thyroid	other; neoplasm	Substitution - Missense
c.823A>G; p.I275V; 15:58643891-58643891	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1404T>G; p.G468G; 15:58621578-58621578	breast	carcinoma	Substitution - coding silent
c.1268C>T; p.S423F; 15:58627792-58627792	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1202C>T; p.P401L; 15:58627858-58627858	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1323C>T; p.S441S; 15:58627737-58627737	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent

The somatic mutations from COSMIC database