| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5580 |
Name | PRKCD |
Synonymous | protein kinase C, delta;PRKCD;protein kinase C, delta |
Definition | protein kinase C delta VIII|protein kinase C delta type|tyrosine-protein kinase PRKCD |
Position | 3p21.31 |
Gene type | protein-coding |
Title | Abstract |
| Protein kinase C delta plays a key role in cellular senescence programs of human normal diploid cells. | In the present study, we clarified that transforming growth factor beta (TGF-beta) induces cellular senescence in human normal diploid cells, TIG-1, and identified protein kinase Cs (PKCs) as downstream mediators of TGF-beta-induced cellular senescence. Among PKCs, we showed that PKC-delta induced cellular senescence in TIG-1 cells and was activated in replicatively and prematurely senescent TIG-1 cells. The causative role of PKC-delta in cellular senescence programs was demonstrated using a kinase negative PKC-delta and small interfering RNA against PKC-delta. Furthermore, PKC-delta was shown to function in human telomerase reverse transcriptase (hTERT) gene repression. These results indicate that PKC-delta plays a key role in cellular senescence programs, and suggest that the induction of senescence and hTERT repression are coordinately regulated by PKC-delta. |