| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 998 |
Name | CDC42 |
Synonymous | cell division cycle 42;CDC42;cell division cycle 42 |
Definition | G25K GTP-binding protein|GTP binding protein, 25kDa|GTP-binding protein, 25kD|cell division control protein 42 homolog|dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))|dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))|growth |
Position | 1p36.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Cdc42(h) + GTP <==> Cdc42(h):GTP (binding) | Cdc42(h) + MLK2(h) <==> Cdc42(h):MLK2(h) (binding) | Cdc42(h) --Caspase-3(h)--> protein remnants (processing) | Cdc42(h) --Caspase-7(h)--> protein remnants (processing) | Cdc42(h) + RhoGDI-1(h) <==> Cdc42(h):RhoGDI-1(h) (binding) | Cdc42(h) + caveolin-1(h) <==> Cdc42(h):caveolin-1(h) (binding) | Cdc42(h) --> MLCK(h){p} (increase of phosphorylation) | Cdc42(h) --> FasL(h) (increase of abundance) | Cdc42(h) --> ER-alpha(h) (regulation of protein activity) | Cdc42(h) --> SH3PX1(h) (activation) | Cdc42(h) --> p65PAK(h) (activation) | IQGAP1(h):CD44(h) + Cdc42(h) <==> IQGAP1(h):CD44(h):Cdc42(h) (binding) | Cdc42(h) + CAPRI(m) <==> Cdc42(h):CAPRI(m) (binding) | Cdc42(h) + BPGAP1(h) <==> Cdc42(h):BPGAP1(h) (binding) | Cdc42(h) + RhoGDI(h) <==> Cdc42(h):RhoGDI(h) (binding) | Cdc42(h) + Vav(h) <==> Cdc42(h):Vav(h) (binding) [re. | Cdc42(h) + Vav(h) <==> Cdc42(h):Vav(h) (binding) [re. | Cdc42(h) + WASP(m.s.) <==> Cdc42(h):WASP(m.s.) (binding) | Cdc42(h) + BNIP-2(h) <==> Cdc42(h):BNIP-2(h) (binding) | Cdc42(h) + PAK3b(m) <==> Cdc42(h):PAK3b(m) (binding) | Cdc42(h) + PAK3a(m) <==> Cdc42(h):PAK3a(m) (binding) | p65PAK(h) + Cdc42(h) <==> p65PAK(h):Cdc42(h) (binding) | PAK4(h) + Cdc42(h) <==> PAK4(h):Cdc42(h) (binding) | Cdc42(h) + Borg5(h) <==> Cdc42(h):Borg5(h) (binding) | Cdc42(h) + Cool-1(h) + SH2D1A(h) <==> Cdc42(h):Cool-1(h):SH2D1A(h) (binding) | Cdc42(h) + EF1G(h) <==> Cdc42(h):EF1G(h) (binding) | Cdc42(h) + RG4(h) <==> Cdc42(h):RG4(h) (binding) | Cdc42(h) + p53(h) <==> Cdc42(h):p53(h) (binding) | Cdc42(h) + RIF1(h) <==> Cdc42(h):RIF1(h) (binding) | Cdc42(h) + retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase delta-subunit(h) <==> Cdc42(h):retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase delta-subunit(h) (binding) | Cdc42(h) + c14orf1(h) <==> Cdc42(h):c14orf1(h) (binding) | Cdc42(h) + ubr1(h) <==> Cdc42(h):ubr1(h) (binding) | CDC42(h) --> Cdc42(h) (expression). | STAU1(h) --> Cdc42(h) (binding) | VIP(h) --> Cdc42(h) (activation) | caveolin-1(h) --> Cdc42(h) (regulation of protein activity) | MIP1A(h) --> Cdc42(h) (activation) | CGM1(h) --> Cdc42(h) (activation) | PAR2(h) --> Cdc42(h) (activation) | Gab-1(h) --> Cdc42(h) (regulation of protein activity) | Gab-2(h) --> Cdc42(h) (regulation of protein activity) | Ost(m.s.) --> Cdc42(h) (increase of exchange) | IL-4(m.s.) --> Cdc42(h) (activation) | N-Myc(m.s.) --> Cdc42(h) (decrease of abundance) | LAMA5(h) --> Cdc42(h) (activation) | ACK-2(m.s.) + Cdc42-isoform2(h) <==> ACK-2(m.s.):Cdc42-isoform2(h) (binding) | CDC42(h) --> Cdc42-isoform2(h) (expression). | CDC42(h) --> Cdc42-isoform1(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 188 | Cysteine methyl ester. | Swiss-Prot 53.0 | 188 | S-geranylgeranyl cysteine. | Swiss-Prot 53.0 | 64 | Phosphotyrosine (Src) | 14506284 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 22250207 - 22252207 | Agilent_014791 |
chr1 |
Promoter: 22250207 - 22252207 | GSE27584 |
chr1 |
Promoter: 22250207 - 22252207 | GSE27584 |
chr1 |
Promoter: 22250207 - 22252207 | GSE27584 |
chr1 |
Promoter: 22250207 - 22252207 | Agilent_014791_44K |