| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 983 |
Name | CDK1 |
Synonymous | cyclin-dependent kinase 1;CDK1;cyclin-dependent kinase 1 |
Definition | cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2, G1 to S and G2 to M|cell division protein kinase 1|p34 protein kinase |
Position | 10q21.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | cyclinA(h) + Cdk1(h) <==> cyclinA(h):Cdk1(h) (binding) | cyclinB(h) + Cdk1(h) <==> cyclinB(h):Cdk1(h) (binding) | Cdk1(h) + NHERF-1(h) <==> Cdk1(h):NHERF-1(h) (binding) | Cdk1(h) + KAP(h) <==> Cdk1(h):KAP(h) (binding) | Cdk1(h) + ATP --Wee1(h)--> Cdk1(h){pY15} + ADP (phosphorylation) | Cdk1(h) + 14-3-3sigma(m) <==> Cdk1(h):14-3-3sigma(m) (binding) | Cdk1(h) + 14-3-3sigma(h) <==> Cdk1(h):14-3-3sigma(h) (binding) | Cdk1(h) + p73alpha(v.s.) <==> Cdk1(h):p73alpha(v.s.) (binding) | Cdk1(h) + p73beta(h) <==> Cdk1(h):p73beta(h) (binding) | Cdk1(h) + PLZF(h) <==> PLZF(h):Cdk1(h) (binding) | PC3(v.s.) + Cdk1(h) <==> PC3(v.s.):Cdk1(h) (binding) | Cdk1(h) + Ptc1(h) <==> Cdk1(h):Ptc1(h) (binding) | Cdk1(h) --> cyclinB1(h) (binding) | Cdk1(h) --> AR(h){p} (increase of phosphorylation) | brca1(h) + Cdk1(h) <==> brca1(h):Cdk1(h) (binding) | Cdk1(h) + MGMT(h) <==> Cdk1(h):MGMT(h) (binding) | GADD45-alpha(h) + Cdk1(h) <==> GADD45-alpha(h):Cdk1(h) (binding) | cyclinB1(h) + Cdk1(h) <==> cyclinB1(h):Cdk1(h) (binding) | Cdk1(h) + GADD45-gamma(h) <==> Cdk1(h):GADD45-gamma(h) (binding) | Cdk1(h) + GADD45-beta(h) <==> Cdk1(h):GADD45-beta(h) (binding) | CDP(m.s.) + Cdk1(h) <==> CDP(m.s.):Cdk1(h) (binding) | CDP(h) + MO15(h) + cyclinA(h) + Cdk1(h) <==> CDP(h):MO15(h):cyclinA(h):Cdk1(h) (binding) | Cdk1(h) + HCV-NS5A(HCV) <==> Cdk1(h):HCV-NS5A(HCV) (binding) | p21Cip1(h) + Cdk1(h) <==> p21Cip1(h):Cdk1(h) (binding) | Cdk1(h) + ATP --> Cdk1(h){pY15} + ADP (phosphorylation) | ErbB2(h) + Cdk1(h) <==> Cdk1(h):ErbB2(h) (binding) | proCaspase-9(m.s.) + Cdk1(h) <==> proCaspase-9(m.s.):Cdk1(h) (binding) | Separin(h) + Cdk1(h) <==> Separin(h):Cdk1(h) (binding) | Separin(m.s.) + cyclinB1(h) + Cdk1(h) <==> Separin(m.s.):cyclinB1(h):Cdk1(h) (binding) | Cdk1(h) + Separin(h){pS1126} <==> Cdk1(h):Separin(h){pS1126} (binding) | Cdk1(h) + (14-3-3sigma(m.s.))2 <==> Cdk1(h):(14-3-3sigma(m.s.))2 (binding) | CDC2(h) --> Cdk1(h) (expression). | C/EBPalpha(h) --/ Cdk1(h) (decrease of abundance) | Tau(h) + ATP --Cdk1(h)--> Tau(h){pT231} + ADP (phosphorylation) | HMGI-C(m) + ATP --Cdk1(h)--> HMGI-C(m){p} + ADP (phosphorylation) | hamartin(h) + ATP --Cdk1(h)--> hamartin(h){pT417}{pS584}{pT1047} + ADP (phosphorylation) | BRCA2(h) + ATP --Cdk1(h)--> BRCA2(h){p} + ADP (phosphorylation) | Rad9a(h) + 4 ATP --Cdk1(h)--> Rad9a(h){pS277}{pS328}{pS336}{pT355} + 4 ADP (phosphorylation) | APP695(m.s.) + ATP --Cdk1(h)--> APP695(m.s.){pT668} + ADP (phosphorylation) | APLP1(m) + ATP --Cdk1(h)--> APLP1(m){p} + ADP (phosphorylation) | APLP2-isoform1(h) + ATP --Cdk1(h)--> APLP2-isoform1(h){pT736} + ADP (phosphorylation) | APP695(m.s.) + ATP --Cdk1(h)--> APP695(m.s.){pT} + ADP (phosphorylation) | vimentin(h) + ATP --Cdk1(h)--> vimentin(h){pS55} + ADP (phosphorylation) | Cdc20(h) + ATP --Cdk1(h)--> Cdc20(h){p} + ADP (phosphorylation) | pRb(m.s.) + ATP --Cdk1(h)--> pRb(m.s.){pS795} + ADP (phosphorylation) | Cdk1-isoform1(h) + brca1(h) <==> Cdk1-isoform1(h):brca1(h) (binding) | CDC2(h) --> Cdk1-isoform1(h) (expression). | CDC2(h) --> Cdk1-isoform2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
There is no record for CDK1 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr10 |
Promoter: 62206742 - 62208742 | GSE27584 |
chr10 |
Promoter: 62208417 - 62210417 | GSE27584 |
chr10 |
Promoter: 62206742 - 62208742 | Agilent_014791_44K |
chr10 |
Promoter: 62206742 - 62208742 | Agilent_014791 |
chr10 |
Promoter: 62208417 - 62210417 | Agilent_014791 |