| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 983 |
Name | CDK1 |
Synonym | CDC2|CDC28A|P34CDC2;cyclin-dependent kinase 1;CDK1;cyclin-dependent kinase 1 |
Definition | cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2, G1 to S and G2 to M|cell division protein kinase 1|p34 protein kinase |
Position | 10q21.1 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Recruitment of NuMA to mitotic centrosomes;PID Reactome;500382 |
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Retinoic acid receptors-mediated signaling;PID Curated;200142 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | Phosphorylation of the APC/C;PID Reactome;500395 |
Pathway | E2F-enabled inhibition of pre-replication complex formation;PID Reactome;500374 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | akap95 role in mitosis and chromosome dynamics;PID BioCarta;100247 |
Pathway | Loss of Nlp from mitotic centrosomes;PID Reactome;500384 |
Pathway | cell cycle: g2/m checkpoint;PID BioCarta;100159 |
Pathway | ERK1 activation;PID Reactome;500085 |
Pathway | Cdc20:Phospho-APC/C mediated degradation of Cyclin A;PID Reactome;500491 |
Pathway | Cyclin B2 mediated events;PID Reactome;500975 |
Pathway | APC/C:Cdc20 mediated degradation of Cyclin B;PID Reactome;500397 |
Pathway | regulation of splicing through sam68;PID BioCarta;100036 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046 |
Pathway | PLK1 signaling events;PID Curated;200087 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | protein kinase a at the centrosome;PID BioCarta;100246 |
Pathway | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;PID Reactome;500318 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | Phosphorylation of Emi1;PID Reactome;500392 |
Pathway | how progesterone initiates the oocyte maturation;PID BioCarta;100104 |
Pathway | AP-1 transcription factor network;PID Curated;200118 |
Pathway | regulation of cell cycle progression by plk3;PID BioCarta;100068 |
Pathway | cdc25 and chk1 regulatory pathway in response to dna damage;PID BioCarta;100212 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;PID Reactome;500930 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | G2/M DNA replication checkpoint;PID Reactome;500939 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | stathmin and breast cancer resistance to antimicrotubule agents;PID BioCarta;100027 |
Pathway | cyclins and cell cycle regulation;PID BioCarta;100207 |
Pathway | sonic hedgehog receptor ptc1 regulates cell cycle;PID BioCarta;100060 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | Cyclin A/B1 associated events during G2/M transition;PID Reactome;500991 |
Pathway | Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Reactome;REACT:6850 |
Pathway | Regulation of APC/C activators between G1/S and early anaphase;PID Reactome;500391 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Loss of proteins required for interphase microtubule organization from the centrosome;PID Reactome;500383 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Disease | Dementia;GAD |
Disease | Alzheimer's disease;GAD |
Disease | NEUROLOGICAL;GAD |
External Links | |
Links to Entrez Gene | 983 |
Links to all GeneRIF Items | 983 |
Links to iHOP | 983 |
Sequence Information | |
Nucleotide Sequence | >983 : length: 1999 TTGAAACTGCTCGCACTTGGCTTCAAAGCTGGCTCTTGGAAATTGAGCGGAGAGCGACGC GGTTGTTGTAGCTGCCGCTGCGGCCGCCGCGGAATAATAAGCCGGGTACAGTGGCTGGGG TCAGGGTCGTGTCTAGGGGACGGCCGAGGGCCTCGGAGGGCGAGTATTGAGGAACGGGGT CCTCTAAGAAGGCCGGACTGGAGGATCTACCATACCCATTGACTAACTATGGAAGATTAT ACCAAAATAGAGAAAATTGGAGAAGGTACCTATGGAGTTGTGTATAAGGGTAGACACAAA ACTACAGGTCAAGTGGTAGCCATGAAAAAAATCAGACTAGAAAGTGAAGAGGAAGGGGTT CCTAGTACTGCAATTCGGGAAATTTCTCTATTAAAGGAACTTCGTCATCCAAATATAGTC AGTCTTCAGGATGTGCTTATGCAGGATTCCAGGTTATATCTCATCTTTGAGTTTCTTTCC ATGGATCTGAAGAAATACTTGGATTCTATCCCTCCTGGTCAGTACATGGATTCTTCACTT GTTAAGAGTTATTTATACCAAATCCTACAGGGGATTGTGTTTTGTCACTCTAGAAGAGTT CTTCACAGAGACTTAAAACCTCAAAATCTCTTGATTGATGACAAAGGAACAATTAAACTG GCTGATTTTGGCCTTGCCAGAGCTTTTGGAATACCTATCAGAGTATATACACATGAGGTA GTAACACTCTGGTACAGATCTCCAGAAGTATTGCTGGGGTCAGCTCGTTACTCAACTCCA GTTGACATTTGGAGTATAGGCACCATATTTGCTGAACTAGCAACTAAGAAACCACTTTTC CATGGGGATTCAGAAATTGATCAACTCTTCAGGATTTTCAGAGCTTTGGGCACTCCCAAT AATGAAGTGTGGCCAGAAGTGGAATCTTTACAGGACTATAAGAATACATTTCCCAAATGG AAACCAGGAAGCCTAGCATCCCATGTCAAAAACTTGGATGAAAATGGCTTGGATTTGCTC TCGAAAATGTTAATCTATGATCCAGCCAAACGAATTTCTGGCAAAATGGCACTGAATCAT CCATATTTTAATGATTTGGACAATCAGATTAAGAAGATGTAGCTTTCTGACAAAAAGTTT CCATATGTTATATCAACAGATAGTTGTGTTTTTATTGTTAACTCTTGTCTATTTTTGTCT TATATATATTTCTTTGTTATCAAACTTCAGCTGTACTTCGTCTTCTAATTTCAAAAATAT AACTTAAAAATGTAAATATTCTATATGAATTTAAATATAATTCTGTAAATGTGTGTAGGT CTCACTGTAACAACTATTTGTTACTATAATAAAACTATAATATTGATGTCAGGAATCAGG AAAAAATTTGAGTTGGCTTAAATCATCTCAGTCCTTATGGCAGTTTTATTTTCCTGTAGT TGGAACTACTAAAATTTAGGAAAATGCTAAGTTCAAGTTTCGTAATGCTTTGAAGTATTT TTATGCTCTGAATGTTTAAATGTTCTCATCAGTTTCTTGCCATGTTGTTAACTATACAAC CTGGCTAAAGATGAATATTTTTCTACTGGTATTTTAATTTTTGACCTAAATGTTTAAGCA TTCGGAATGAGAAAACTATACAGATTTGAGAAATGATGCTAAATTTATAGGAGTTTTCAG TAACTTAAAAAGCTAACATGAGAGCATGCCAAAATTTGCTAAGTCTTACAAAGATCAAGG GCTGTCCGCAACAGGGAAGAACAGTTTTGAAAATTTATGAACTATCTTATTTTTAGGTAG GTTTTGAAAGCTTTTTGTCTAAGTGAATTCTTATGCCTTGGTCAGAGTAATAACTGAAGG AGTTGCTTATCTTGGCTTTCGAGTCTGAGTTTAAAACTACACATTTTGACATAGTGTTTA TTAGCAGCCATCTAAAAAGGCTCTAATGTATATTTAACTAAAATTACTAGCTTTGGGAAT TAAACTGTTTAACAAATAA |
Protein Sequence | >983 : length: 297 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM |