Entrez Gene

Basic Information
Gene ID	9261
Name	MAPKAPK2
Synonymous	mitogen-activated protein kinase-activated protein kinase 2;MAPKAPK2;mitogen-activated protein kinase-activated protein kinase 2
Definition	MAP kinase-activated protein kinase 2\|MAPK-activated protein kinase 2\|MAPKAP kinase 2
Position	1q32
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
MAPKAPK2(h) + ATP --p38alpha(h){p}--> MAPKAPK2(h){p} + ADP (phosphorylation)
MAPKAPK2(h) + ATP --p38alpha(h)--> MAPKAPK2(h){p} + ADP (phosphorylation)
MAPKAPK2(h) + ATP --p38beta1(h)--> MAPKAPK2(h){p} + ADP (phosphorylation)
MAPKAPK2(h) + ATP --p38alpha(m)--> MAPKAPK2(h){p} + ADP (phosphorylation)
MAPKAPK2(h) + ATP --p38gamma(h)--> MAPKAPK2(h){p} + ADP (phosphorylation)
MAPKAPK2(h) + p38alpha(m.s.) <==> MAPKAPK2(h):p38alpha(m.s.) (binding)
Hsp27(h) + MAPKAPK2(h) + AKT(h) + p38(h) <==> Hsp27(h):MAPKAPK2(h):AKT(h):p38(h) (binding)
AKT(m.s.) + MAPKAPK2(h) <==> AKT(m.s.):MAPKAPK2(h) (binding)
MAPKAPK2(h) + ATP --> MAPKAPK2(h){pT334} + ADP (phosphorylation)
MAPKAPK2(h) --> MAPKAPK2(h) (expression).
SRF(h) + ATP --MAPKAPK2(h)--> SRF(h){pS103} + ADP (phosphorylation)
Hsp27(m.s.) + ATP --MAPKAPK2(h)--> Hsp27(m.s.){p} + ADP (phosphorylation)
MAPKAPK2(h) --> MAPKAPK2-1(h) (expression).
MAPKAPK2(h) --> MAPKAPK2-2(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
328	Phosphoserine (by autocatalysis) (Bysimilarity).		Swiss-Prot 53.0
334	Phosphothreonine (by MAPK) (Bysimilarity).		Swiss-Prot 53.0
338	Phosphothreonine (By similarity).		Swiss-Prot 53.0
338	Phosphothreonine (MAPKAPK2)	8846784	Phospho.ELM 6.0
9	Phosphoserine (MAPK1)	8846784	Phospho.ELM 6.0

Transcription Factors [Top]