Entrez Gene

Basic Information
Gene ID	9261
Name	MAPKAPK2
Synonymous	mitogen-activated protein kinase-activated protein kinase 2;MAPKAPK2;mitogen-activated protein kinase-activated protein kinase 2
Definition	MAP kinase-activated protein kinase 2\|MAPK-activated protein kinase 2\|MAPKAP kinase 2
Position	1q32
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1107G>A; p.Q369Q; 1:206732622-206732622	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1107G>A; p.Q369Q; 1:206732622-206732622	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.771G>A; p.L257L; 1:206731141-206731141	breast	carcinoma	Substitution - coding silent
c.986C>T; p.T329I; 1:206731846-206731846	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.837C>T; p.I279I; 1:206731207-206731207	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1132G>C; p.A378P; 1:206732647-206732647	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.951C>G; p.T317T; 1:206731698-206731698	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.305G>A; p.R102H; 1:206728735-206728735	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.305G>A; p.R102H; 1:206728735-206728735	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.952G>A; p.E318K; 1:206731699-206731699	skin	malignant_melanoma	Substitution - Missense
c.972G>T; p.W324C; 1:206731719-206731719	prostate	carcinoma	Substitution - Missense
c.458G>A; p.R153Q; 1:206729073-206729073	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.458G>A; p.R153Q; 1:206729073-206729073	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.160A>C; p.I54L; 1:206685389-206685389	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.376A>T; p.N126Y; 1:206728806-206728806	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.102_104delGCC; p.P40delP; 1:206685331-206685333	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - In frame
c.570G>T; p.E190D; 1:206729977-206729977	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1003C>T; p.P335S; 1:206731863-206731863	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.482G>A; p.R161K; 1:206729097-206729097	prostate	carcinoma	Substitution - Missense
c.493G>A; p.E165K; 1:206729404-206729404	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.493G>A; p.E165K; 1:206729404-206729404	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.351C>T; p.I117I; 1:206728781-206728781	skin	malignant_melanoma	Substitution - coding silent
c.195C>T; p.V65V; 1:206685424-206685424	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.790T>G; p.Y264D; 1:206731160-206731160	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1161G>T; p.R387R; 1:206732676-206732676	breast	carcinoma	Substitution - coding silent
c.111G>C; p.P37P; 1:206685340-206685340	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.553C>T; p.R185W; 1:206729464-206729464	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.101_102insGCC; p.P40_Q41insP; 1:206685330-206685331	breast	carcinoma	Insertion - In frame
c.114G>C; p.P38P; 1:206685343-206685343	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.643A>C; p.T215P; 1:206730050-206730050	thyroid	other; neoplasm	Substitution - Missense
c.643A>C; p.T215P; 1:206730050-206730050	skin; ear	malignant_melanoma	Substitution - Missense
c.951C>T; p.T317T; 1:206731698-206731698	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.714G>T; p.E238D; 1:206730710-206730710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.533A>G; p.H178R; 1:206729444-206729444	liver	carcinoma	Substitution - Missense
c.152G>T; p.G51V; 1:206685381-206685381	thyroid	other; neoplasm	Substitution - Missense
c.1171C>A; p.R391R; 1:206732686-206732686	thyroid	other; neoplasm	Substitution - coding silent
c.929C>T; p.P310L; 1:206731676-206731676	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1175C>A; p.A392D; 1:206732690-206732690	thyroid	other; neoplasm	Substitution - Missense
c.457C>T; p.R153*; 1:206729072-206729072	skin	malignant_melanoma	Substitution - Nonsense
c.832C>T; p.R278C; 1:206731202-206731202	urinary_tract; bladder	carcinoma	Substitution - Missense
c.277A>G; p.K93E; 1:206685506-206685506	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.872G>A; p.W291*; 1:206731242-206731242	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.507C>T; p.S169S; 1:206729418-206729418	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1102G>T; p.E368*; 1:206732617-206732617	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.944C>A; p.T315N; 1:206731691-206731691	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.451C>T; p.Q151*; 1:206729066-206729066	skin	malignant_melanoma	Substitution - Nonsense
c.184G>T; p.D62Y; 1:206685413-206685413	urinary_tract; bladder	carcinoma	Substitution - Missense
c.184G>T; p.D62Y; 1:206685413-206685413	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.839G>A; p.R280Q; 1:206731209-206731209	pancreas	carcinoma	Substitution - Missense
c.714G>A; p.E238E; 1:206730710-206730710	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.696A>C; p.P232P; 1:206730692-206730692	central_nervous_system; brain	glioma	Substitution - coding silent
c.691+1G>A; p.?; 1:206730099-206730099	oesophagus	carcinoma	Unknown
c.360C>T; p.I120I; 1:206728790-206728790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.762C>A; p.Y254*; 1:206730758-206730758	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.166A>G; p.K56E; 1:206685395-206685395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1048G>T; p.E350*; 1:206731908-206731908	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1091G>A; p.R364H; 1:206732606-206732606	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1091G>A; p.R364H; 1:206732606-206732606	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1091G>A; p.R364H; 1:206732606-206732606	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.506G>T; p.S169I; 1:206729417-206729417	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.372C>T; p.Y124Y; 1:206728802-206728802	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.364G>T; p.D122Y; 1:206728794-206728794	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.385G>A; p.A129T; 1:206728815-206728815	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.171C>G; p.N57K; 1:206685400-206685400	ovary	other; neoplasm	Substitution - Missense
c.171C>G; p.N57K; 1:206685400-206685400	ovary	other; neoplasm	Substitution - Missense
c.606C>T; p.I202I; 1:206730013-206730013	skin	malignant_melanoma	Substitution - coding silent
c.1107G>T; p.Q369H; 1:206732622-206732622	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.833G>A; p.R278H; 1:206731203-206731203	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.284T>G; p.L95R; 1:206728714-206728714	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1020G>T; p.R340R; 1:206731880-206731880	skin	malignant_melanoma	Substitution - coding silent
c.1093G>A; p.V365I; 1:206732608-206732608	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]