| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 9212 |
Name | AURKB |
Synonymous | aurora kinase B;AURKB;aurora kinase B |
Definition | ARK-2|STK-1|aurora 1|aurora kinase B-Sv1|aurora kinase B-Sv2|aurora- and Ipl1-like midbody-associated protein 1|aurora-1|aurora-B|aurora-related kinase 2|aurora/IPL1-related kinase 2|protein phosphatase 1, regulatory subunit 48|serine/threonine kinase 12| |
Position | 17p13.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | RasGAP(h) + Aurora-B(h) <==> RasGAP(h):Aurora-B(h) (binding) | Aurora-B(h) + survivin(mo) <==> Aurora-B(h):survivin(mo) (binding) | Hec1(h) + Aurora-B(h) <==> Hec1(h):Aurora-B(h) (binding) | Nuf2(h) + Aurora-B(h) <==> Nuf2(h):Aurora-B(h) (binding) | Cdc20(h) + Aurora-B(h) <==> Cdc20(h):Aurora-B(h) (binding) | INCENP(h) + survivin(h) + Aurora-B(h) <==> INCENP(h):survivin(h):Aurora-B(h) (binding) | Aurora-B(h) + survivin(h) <==> Aurora-B(h):survivin(h) (binding) | INCENP(h) + Aurora-B(h) <==> INCENP(h):Aurora-B(h) (binding) | Aurora-B(h) + Aurora-C(h) <==> Aurora-B(h):Aurora-C(h) (binding) | INCENP(h){p} + Aurora-B(h) <==> INCENP(h){p}:Aurora-B(h) (binding) | Aurora-B(h) + PP1-gamma1(h) <==> Aurora-B(h):PP1-gamma1(h) (binding) | Aurora-B(h) + PP1-beta(h) <==> Aurora-B(h):PP1-beta(h) (binding) | Aurora-B(h) + PP1-alpha(h) <==> Aurora-B(h):PP1-alpha(h) (binding) | Aurora-B(h) + PP2ACalpha(h) <==> Aurora-B(h):PP2ACalpha(h) (binding) | Aurora-B(h) + INCENP(h) + MKlp2(h) <==> Aurora-B(h):INCENP(h):MKlp2(h) (binding) | Aurora-B(h) --> Aurora-B(h) (translocation) | n ubiquitin(h) + Aurora-B(h) --> Aurora-B(h){ub(n)} (ubiquitination) | Aurora-B(h) + Cdc27(h) <==> Aurora-B(h):Cdc27(h) (binding) | Aurora-B(h) + Fzr1(h) <==> Aurora-B(h):Fzr1(h) (binding) | survivin(h) + borealin(h) + Aurora-B(h) + INCENP-xbb1(h) <==> survivin(h):borealin(h):Aurora-B(h):INCENP-xbb1(h) (binding) | INCENP(h) + Aurora-B(h) + borealin(h) + survivin(h) <==> INCENP(h):Aurora-B(h):borealin(h):survivin(h) (binding) | Aurora-B(h) + INCENP(h) <==> Aurora-B(h):INCENP(h) (binding) | Aurora-B(h) + INCENP(m) <==> Aurora-B(h):INCENP(m) (binding) | Aurora-B(h) + INCENP-xbb1(h) <==> Aurora-B(h):INCENP-xbb1(h) (binding) | Evi5(h) + Aurora-B(h) <==> Evi5(h):Aurora-B(h) (binding) | Evi5(h) + Aurora-B(h) <==> Evi5(h):Aurora-B(h) (binding) | Evi5(h) + INCENP(h) + Aurora-B(h) + survivin(h) <==> Evi5(h):INCENP(h):Aurora-B(h):survivin(h) (binding) | Aurora-B(h) --> protein remnants (degradation) | Aurora-B(h) --> Aurora-B(h) (translocation) | CUL3(h) + Aurora-B(h) <==> CUL3(h):Aurora-B(h) (binding) | KLHL9(h) + Aurora-B(h) <==> KLHL9(h):Aurora-B(h) (binding) | KLHL13(h) + Aurora-B(h) <==> KLHL13(h):Aurora-B(h) (binding) | Aurora-B(h) + CUL3(h):KLHL9(h):KLHL13(h) <==> Aurora-B(h):CUL3(h):KLHL9(h):KLHL13(h) (binding) | Aurora-B(h) + n ubiquitin(h) --CUL3(h)--> Aurora-B(h){ub}n (ubiquitination) | AURKB(h) --> Aurora-B(h) (expression). | Aurora-B(h) --> Aurora-B(h) (translocation) | Aurora-B(h) --> Aurora-B(h) (translocation) | Nuf2(h) + ATP --Aurora-B(h)--> Nuf2(h){p} + ADP (phosphorylation) | Hec1(h) + ATP --Aurora-B(h)--> Hec1(h){p} + ADP (phosphorylation) | survivin(h) + ATP --Aurora-B(h)--> survivin(h){pT117} + ADP (phosphorylation) | CENP-A(h) + ATP --Aurora-B(h)--> CENP-A(h){pS7} + ADP (phosphorylation) | histone H3(v.s.) + ATP --Aurora-B(h)--> histone H3(v.s.){p} + ADP (phosphorylation) | Lats2(h) + ATP --Aurora-B(h)--> Lats2(h){pS83} + ADP (phosphorylation) | histone H3(h) + 2 ATP --Aurora-B(h)--> histone H3(h){pS11}{pS29} + 2 ADP (phosphorylation) | topoisomerase-II-alpha(h) + ATP --Aurora-B(h)--> topoisomerase-II-alpha(h){p} + ADP (phosphorylation) | topoisomerase-II-alpha-isoform1(h) + ATP --Aurora-B(h)--> topoisomerase-II-alpha-isoform1(h){p} + ADP (phosphorylation) | MCAK(h) + ATP --Aurora-B(h)--> MCAK(h){pS92} + ADP (phosphorylation) | vimentin(h) + ATP --Aurora-B(h)--> vimentin(h){pS72} + ADP (phosphorylation) | Aurora-B(h) + MKlp2(h) <==> Aurora-B(h):MKlp2(h) (binding) | survivin(h) + Aurora-B(h) <==> survivin(h):Aurora-B(h) (binding) | Aurora-B(h) + ATP --Chk1(h)--> Aurora-B(h){p} + ADP (phosphorylation) | Aurora-B(h) + n ubiquitin(h) --E2-C(h),cyclosome(x):Fzr1(h)--> Aurora-B(h){ub(n)} (ubiquitination) | Aurora-B(h) + ubiquitin(h) --E2-C(h),cyclosome(x):Cdc20(h)--> Aurora-B(h){ub} (ubiquitination) | Aurora-B(h) --> protein remnants (degradation) | AURKB(h) --> Aurora-B(h) (expression). | borealin(h) + ATP --Aurora-B(h)--> borealin(h){p} + ADP (phosphorylation) | MgcRacGAP(h) + ATP --Aurora-B(h)--> MgcRacGAP(h){p} + ADP (phosphorylation) |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 7 | Phosphoserine. | Swiss-Prot 53.0 | 12 | Phosphotyrosine. | Swiss-Prot 53.0 | 232 | Phosphothreonine. | Swiss-Prot 53.0 | 232 | Phosphothreonine (Aurora B) | 14722118 | Phospho.ELM 6.0 | 12 | Phosphotyrosine | 16565220 | Phospho.ELM 6.0 | 7 | Phosphoserine | 16565220 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 8054108 - 8056108 | Agilent_014791 |
chr17 |
Promoter: 8054108 - 8056108 | GSE27584 |