Entrez Gene

Basic Information
Gene ID	7150
Name	TOP1
Synonymous	topoisomerase (DNA) I;TOP1;topoisomerase (DNA) I
Definition	DNA topoisomerase 1\|type I DNA topoisomerase
Position	20q12-q13.1
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
TopoI(h) --Caspase-3(h)--> protein remnants (processing)
TopoI(h) + Abl(h) <==> TopoI(h):Abl(h) (binding)
TopoI(h) + Abl(m.s.) <==> TopoI(h):Abl(m.s.) (binding)
TopoI(h) + ATP --Abl(h)--> TopoI(h){pY} + ADP (phosphorylation)
TopoI(h) + ATP --Abl(m.s.)--> TopoI(h){pY268} + ADP (phosphorylation)
TopoI(h) + ATP --Abl(h)--> TopoI(h){pY268} + ADP (phosphorylation)
c-Jun(m.s.) + TopoI(h) + hnRNPM(h) + Gu-alpha(h) + RHA(h) <==> c-Jun(m.s.):TopoI(h):hnRNPM(h):Gu-alpha(h):RHA(h) (binding)
c-Jun(m.s.) + TopoI(h) <==> c-Jun(m.s.):TopoI(h) (binding)
c-Jun(h) + TopoI(h) <==> c-Jun(h):TopoI(h) (binding)
TopoI(h) + c-Jun(h) + TBP(h) <==> TopoI(h):c-Jun(h):TBP(h) (binding)
TopoI(h) + c-Jun(h){p} <==> TopoI(h):c-Jun(h){p} (binding)
WS(h) + TopoI(h) <==> WS(h):TopoI(h) (binding)
MGMT(h) + TopoI(h) <==> MGMT(h):TopoI(h) (binding)
TopoI(h) + AR-isoform1(h) <==> TopoI(h):AR-isoform1(h) (binding)
TopoI(h) + AR(h) <==> TopoI(h):AR(h) (binding)
p16INK4a-p14(h) + TopoI(h) <==> p16INK4a-p14(h):TopoI(h) (binding)
TOP1(h) --> TopoI(h) (expression).
TopoI(h){pY} --SHP-1(m.s.)--> TopoI(h) + p (dephosphorylation)
c-Jun(h) + TopoI(h) <==> c-Jun(h):TopoI(h) (binding)
TopoI(h) + sumo1(m.s.) --Aos1(m.s.):SAE2(m.s.),Ubc9(h)--> TopoI(h){sumoK117} (sumoylation)
TOP1(h) --> TopoI(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
268	Phosphotyrosine (Abl)	15448168	Phospho.ELM 6.0
10	Phosphoserine	17081983	Phospho.ELM 6.0

Transcription Factors [Top]