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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

6722

Name

SRF

Synonymous

serum response factor (c-fos serum response element-binding transcription factor);SRF;serum response factor (c-fos serum response element-binding transcription factor)

Definition

serum response factor

Position

6p21.1

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

SRF(h) + Elk-1(h) <==> SRF(h):Elk-1(h) (binding; assembly; interaction)
SRF(h) + SAP-1a(h) <==> SRF(h):SAP-1a(h) (binding; interaction; assembly).
SRF(h) + SAP-1b(h) <==> SRF(h):SAP-1b(h) (binding).
TFIIF(h) + SRF(h) <==> TFIIF(h):SRF(h) (binding).
TCF(m) + SRF(h) <==> TCF(m):SRF(h) (binding).
PMX1(h) + SRF(h) <==> PMX1(h):SRF(h) (binding).
Barx2b(m) + SRF(h) <==> Barx2b(m):SRF(h) (binding).
SRF(h) --> ACTB(h) (DNA binding).
SRF(h) --> apoE(h) (DNA binding).
SRF(h) --> Egr2(m) (DNA binding).
SRF(h) --> Actb(r) (DNA binding).
SRF(h) + ATP --MAPKAPK2(h)--> SRF(h){pS103} + ADP (phosphorylation)
SRF(h) + ATP --CaMKII(r)--> SRF(h){pS103}{pT160} + ADP (phosphorylation)
TFII-I(h) + SRF(h) <==> TFII-I(h):SRF(h) (binding)
SRF(h) + SRF(h) <==> SRF(h):SRF(h) (binding)
SRF(h) + TFIIF-alpha(h) <==> SRF(h):TFIIF-alpha(h) (binding).
TCF(h) + SRF(h) <==> TCF(h):SRF(h) (binding).
Net(h) + SRF(h) <==> Net(h):SRF(h) (binding).
SRF(h) --> Egr2(h) (DNA binding; transactivation).
Fli-1(h) + SRF(h) <==> SRF(h):Fli-1(h) (assembly; binding; interaction)
myocardin-isoform1(m) + SRF(h) <==> SRF(h):myocardin-isoform1(m) (assembly; binding; interaction)
SRF(h) + NKX3A(m) <==> NKX3A(m):SRF(h) (assembly; binding; interaction)
SRF(h) --> EGR1(h) (DNA binding; transactivation).
SRF(h) --> MYLK(m) (DNA binding; transactivation).
SRF(h) --Caspase-3(h)--> protein remnants (processing)
SRF(h) --Caspase-7(h)--> protein remnants (processing)
SRF(h) + Fli-1(z) <==> Fli-1(z):SRF(h) (binding; interaction)
SRF(h) + GATA-4(r) <==> GATA-4(r):SRF(h) (binding; interaction)
TEF-1(m) + SRF(h) <==> SRF(h):TEF-1(m) (binding; interaction)
SRF(h) + C/EBPbeta(LAP)(r) <==> C/EBPbeta(LAP)(r):SRF(h) (binding; interaction)
SRF(h) + HMGIY(m) <==> HMGIY(m):SRF(h) (binding; interaction)
SRF(h) --> MIE(SCMVAGM) (DNA binding; transactivation).
SRF(h) --> IE-1(HCMV) (DNA binding; transactivation).
SRF(h) --> TAGLN(r) (DNA binding; transactivation).
p49/Strap(m.s.) + SRF(h) <==> p49/Strap(m.s.):SRF(h) (binding)
PIAS1(m) + SRF(h) <==> PIAS1(m):SRF(h) (binding)
NF-YA(m.s.) + SRF(h) <==> NF-YA(m.s.):SRF(h) (binding)
SRF(h) --> Fos(m) (DNA binding).
SRF(h) --> Egr1(m) (DNA binding; transactivation).
SRF(h) --> Nppa(r) (DNA binding; transactivation).
SRF(h) --> CAA(c) (DNA binding; transactivation).
SRF(h) --> Myh6(r) (DNA binding).
SRF(h) --> Acta2(m) (DNA binding).
SRF(h) --> ACTA1(h) (DNA binding).
SRF(h) --> ITGA1(h) (DNA binding).
SRF(h) --> ZC3H12A(h) (DNA binding).
SRF(h) --> Vil1(m) (DNA binding).
SRF(h) --> SRF(h) (expression).
thrombin(m.s.) --> SRF(h) (translocation)
SRF(h) --> BZLF1(EBV) (DNA binding; transregulation).
SRF(h) --> FOS(h) (DNA binding; transactivation).
SRF(h) --> Fos(m) (DNA binding).
SRF(h) --> FOS(x) (DNA binding).
SRF(h) --> ACTC1(h) (DNA binding; transactivation).
SRF(h) --> SA-ACT(c) (DNA binding; transactivation).
SRF(h) --> MYL3(h) (DNA binding; transregulation).
SRF(h) --> G-ACT 5C(x) (DNA binding; transregulation).
SRF(h) --> CY-ACT(x) (DNA binding; transregulation).
SRF(h) --> cyr61(m) (DNA binding; transregulation).
SRF(h) --> Cnn1(m) (DNA binding; transactivation).
SRF(h) --> DMD(h) (DNA binding; transactivation).
SRF(h) --> Acta2(r) (DNA binding; transactivation).
SRF(h) --> Nppa(r) (DNA binding; transactivation).
SRF(h) --> MLC1(c) (DNA binding; transactivation).
SRF(h) --> ELK1(h) (DNA binding; transactivation).
SRF(h) --> MYL4(m) (DNA binding; transactivation).
SRF(h) --> MYH11(r) (DNA binding; transactivation).
SRF(h) --> Nr4a1(m) (DNA binding; transactivation).
SRF(h) --> CAA(c) (DNA binding; transactivation).
SRF(h) --> Egr1(m) (DNA binding)
SRF(h) --> SRF(m) (DNA binding).
NF-YA(m.s.) + SRF(h) <==> NF-YA(m.s.):SRF(h) (binding)
SRF(h) + sumo1(h) --> SRF(h){sumoK147} (sumoylation)
SRF(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(m.s.)--> SRF(h){sumoK147} (sumoylation)
SRF(h) --> MYLK(rb) (DNA binding).
SRF(h) --> ITGA1(c) (DNA binding).
SRF(h) --> ACTG2(c) (DNA binding).
SRF(h) --> Tagln(m) (DNA binding).
SRF(h) --> CDKN1A(h) (DNA binding).
SRF(h) --> MYLK(m) (DNA binding).
SRF(h) --> ACTG2(h) (DNA binding).
SRF(h) --> TAGLN(c) (DNA binding).
SRF(h) --> SRF(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

76Phosphotyrosine.Swiss-Prot 53.0
77Phosphoserine.Swiss-Prot 53.0
79Phosphoserine.Swiss-Prot 53.0
83Phosphoserine.Swiss-Prot 53.0
85Phosphoserine.Swiss-Prot 53.0
103Phosphoserine.Swiss-Prot 53.0
224Phosphoserine.Swiss-Prot 53.0
253Phosphoserine.Swiss-Prot 53.0
307O-linked (GlcNAc) (Probable).Swiss-Prot 53.0
309O-linked (GlcNAc) (Probable).Swiss-Prot 53.0
383O-linked (GlcNAc) (Probable).Swiss-Prot 53.0
435Phosphoserine (by dsDNA kinase).Swiss-Prot 53.0
446Phosphoserine (by dsDNA kinase).Swiss-Prot 53.0
77Phosphoserine (CK2 alpha)92191991;2046671Phospho.ELM 6.0
83Phosphoserine (CK2 alpha)92191991;2046671Phospho.ELM 6.0
85Phosphoserine (MAPKAPK2)92191991;10318869;11859076Phospho.ELM 6.0
79Phosphoserine (CK2 alpha)92191991;2046671Phospho.ELM 6.0
435Phosphoserine (DNA-PK)8407951Phospho.ELM 6.0
446Phosphoserine (DNA-PK)8407951Phospho.ELM 6.0
159Phosphothreonine (PKC alpha;DM)12809504Phospho.ELM 6.0
224Phosphoserine17081983Phospho.ELM 6.0
277O-linkedReason AJ., Morris HR., Panico M., Marais R., Treisman RH.,Haltiwanger RS., Hart GW., Kelly WG. and Dell A. (1992)J. Biol. Chem., 267, 16911-16921. Medline: 92380993;OGlycBase6.0
307O-linkedReason AJ., Morris HR., Panico M., Marais R., Treisman RH.,Haltiwanger RS., Hart GW., Kelly WG. and Dell A. (1992)J. Biol. Chem., 267, 16911-16921. Medline: 92380993;OGlycBase6.0
309O-linkedReason AJ., Morris HR., Panico M., Marais R., Treisman RH.,Haltiwanger RS., Hart GW., Kelly WG. and Dell A. (1992)J. Biol. Chem., 267, 16911-16921. Medline: 92380993;OGlycBase6.0
316O-linkedReason AJ., Morris HR., Panico M., Marais R., Treisman RH.,Haltiwanger RS., Hart GW., Kelly WG. and Dell A. (1992)J. Biol. Chem., 267, 16911-16921. Medline: 92380993;OGlycBase6.0
383O-linkedReason AJ., Morris HR., Panico M., Marais R., Treisman RH.,Haltiwanger RS., Hart GW., Kelly WG. and Dell A. (1992)J. Biol. Chem., 267, 16911-16921. Medline: 92380993;OGlycBase6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr6

 Promoter: 43245398 - 43247398Agilent_014791

chr6

 Promoter: 43245398 - 43247398GSE27584

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