Entrez Gene

Basic Information
Gene ID	6720
Name	SREBF1
Synonymous	sterol regulatory element binding transcription factor 1;SREBF1;sterol regulatory element binding transcription factor 1
Definition	SREBP-1\|class D basic helix-loop-helix protein 1\|sterol regulatory element-binding protein 1
Position	17p11.2
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
SREBP-1a(h) --> PPARG(h) (DNA binding; transactivation).
SREBP-1a(h) --> ApoA-IV(r) (DNA binding; transactivation).
SREBP-1a(h) --> ACLY(h) (DNA binding; transactivation).
SREBP-1a(h) + HNF-4alpha(m) <==> SREBP-1a(h):HNF-4alpha(m) (binding)
SREBP-1a(h) --> CDKN1A(h) (DNA binding; transactivation).
SREBP-1a(h) --> ACACA(r) (DNA binding; transactivation).
SREBP-1a(h) --> Fasn(r) (DNA binding; transactivation).
SREBP-1a(h) --> LDLR(pg) (DNA binding; transactivation).
SREBP-1a(h) --> NR0B2(h) (DNA binding).
SREBP-1a(h) + YY1(m) <==> SREBP-1a(h):YY1(m) (binding)
SREBP-1a(h) --> STAR(h) (DNA binding; transactivation).
SREBP-1a(h) --> Acss2(m) (DNA binding; transactivation).
SREBP-1a(h) + ATP --ERK1(h){p}--> SREBP-1a(h){p} + ADP (phosphorylation)
SREBP-1a(h) + ATP --ERK2(m.s.){p}--> SREBP-1a(h){pS117} + ADP (phosphorylation)
SREBP-1a(h) + p300(h) <==> SREBP-1a(h):p300(h) (binding)
SREBP-1a(h) + 2 acetyl-CoA --p300(m.s.)--> SREBP-1a(h){aceK324}{aceK333} + 2 CoA (acetylation)
SREBP-1a(h) + acetyl-CoA --CBP(m.s.)--> SREBP-1a(h){aceK} + CoA (acetylation)
SREBP-1a(h) + p300(m.s.) <==> SREBP-1a(h):p300(m.s.) (binding)
SREBP-1a(h) + ubiquitin(h) --> SREBP-1a(h){ubK333} (ubiquitination)
SREBP-1a(h) + ubiquitin(h) --> SREBP-1a(h){ub} (ubiquitination)
SREBP-1a(h) --> LDLR(h) (transactivation)
SREBP-1a(h) --> HMGCR(h) (transactivation)
SREBP-1a(h) --> FDFT1(h) (DNA binding).
SREBP-1a(h) --> Fdps(r) (DNA binding).
SREBP-1a(h) --> CYP51A1(h) (transactivation)
SREBP-1a(h) --> MLXIPL(r) (DNA binding).
SREBP-1a(h) --> Scd1(m) (DNA binding; transactivation).
SREBP-1a(h) --> PTGS2(h) (DNA binding; transactivation).
SREBP-1a(h) --> FABP6(h) (DNA binding; transactivation).
SREBP-1a(h) --> Scd2(m) (DNA binding).
SREBP-1a(h) --> PCSK9(h) (DNA binding; transactivation).
SREBP-1a(h) --/ Apoa5(h) (transrepression)
SREBP-1a(h) --> DBI(h) (DNA binding; transactivation).
SREBP-1a(h) --> IDH1(h) (DNA binding; transactivation).
SREBP-1a(h) --> Slc25a1(r) (DNA binding).
SREBP-1a(h) --> CYP8B1(r) (DNA binding; transactivation).
SREBP-1a(h) --> FDPS(h) (DNA binding; transactivation).
SREBP-1a(h) --> Cidea(m) (DNA binding; transactivation).
SREBP-1a(h) --> cwp-2(gi) (DNA binding).
SREBF1(h) --> SREBP-1a(h) (expression).
SREBP-1b(h) --> FABP6(h) (DNA binding; transactivation).
SREBF1(h) --> SREBP-1b(h) (expression).
SREBP-1c(h) --> CASP2(h) (DNA binding; transactivation).
SREBP-1c(h) --> ins-1(r) (DNA binding).
SREBP-1c(h) --/ IRS2(h) (DNA binding; transrepression).
SREBP-1c(h) --> HK2(h) (DNA binding).
SREBP-1c(h) + HNF-4alpha2(m) <==> SREBP-1c(h):HNF-4alpha2(m) (binding)
SREBP-1c(h) --> Slc2a2(m) (DNA binding; transactivation).
SREBP-1c(h) --> LDLR(m) (DNA binding).
SREBP-1c(h) --> FABP6(h) (DNA binding; transactivation).
SREBP-1c(h) --> Apoa5(h) (DNA binding).
SREBP-1c(h) --> ABCD2(h) (DNA binding; transactivation).
SREBP-1c(h) --> Slc25a1(r) (DNA binding; transactivation).
SREBP-1c(h) --> Cidea(m) (DNA binding; transactivation).
SREBF1(h) --> SREBP-1c(h) (expression).
SREBP-1(h) --/ CAV1(h) (DNA binding; transrepression).
SREBP-1(h) --> ACACB(h) (DNA binding; transactivation).
SREBP-1(h) --> LDLR(h) (DNA binding).
SREBP-1(h) --> SLC2A4(h) (DNA binding; transactivation).
SREBP-1(h) --> HK2(h) (DNA binding).
SREBP-1(h) --> HMGCR(gl) (DNA binding; transactivation).
SREBP-1(h) --> Fdps(r) (DNA binding).
SREBP-1(h) --> SLC25A1(h) (DNA binding; transactivation).
SREBP-1(h) --> CYP51A1(h) (DNA binding).
SREBP-1(h) --> LPIN1(h) (DNA binding; transactivation).
SREBP-1(h) --> Hsd17b7(h) (DNA binding).
SREBF1(h) --> SREBP-1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
1019	Phosphoserine.		Swiss-Prot 53.0
1020	Phosphoserine.		Swiss-Prot 53.0
117	Phosphoserine (MAPK1;MAPK3)	10915800	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr17	Promoter: 17680550 - 17682550	Agilent_014791
chr17	Promoter: 17680550 - 17682550	GSE27584
chr17	Promoter: 17680550 - 17682550	GSE27584

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]