| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6464 |
Name | SHC1 |
Synonymous | SHC (Src homology 2 domain containing) transforming protein 1;SHC1;SHC (Src homology 2 domain containing) transforming protein 1 |
Definition | SH2 domain protein C1|SHC (Src homology 2 domain-containing) transforming protein 1|SHC-transforming protein 1|SHC-transforming protein 3|SHC-transforming protein A |
Position | 1q21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IGF-1R(h){p} + Shc-1-p52(h) <==> IGF-1R(h){p}:Shc-1-p52(h) (binding) | InsR(h){p} + Shc-1-p52(h) <==> InsR(h){p}:Shc-1-p52(h) (binding) | Grb-2(h) + Shc-1-p52(h) <==> Grb-2(h):Shc-1-p52(h) (binding) | huntingtin(h) + Shc-1-p52(h) <==> huntingtin(h):Shc-1-p52(h) (binding) | IRS-1(r) + Shc-1-p52(h) <==> IRS-1(r):Shc-1-p52(h) (binding) | Shc-1-p52(h) + APP(m.s.){pY} <==> Shc-1-p52(h):APP(m.s.){pY} (binding) | Shc-1-p52(h) + ATP --> Shc-1-p52(h){pY} + ADP (phosphorylation) | Shc-1-p52(h) + ErbB2(h){pY} <==> Shc-1-p52(h):ErbB2(h){pY} (binding) | Shc-1-p52(h) + ErbB3(h){pY} <==> Shc-1-p52(h):ErbB3(h){pY} (binding) | Shc-1-p52(h) + ER-alpha(h) <==> Shc-1-p52(h):ER-alpha(h) (binding) | Shc-1-p52(h) + Sos(h) + Grb-2(h) <==> Shc-1-p52(h):Sos(h):Grb-2(h) (binding) | Shc-1-p52(h) + ErbB4(h){pY} <==> Shc-1-p52(h):ErbB4(h){pY} (binding) | Shc-1-p52(h) + ATP --> Shc-1-p52(h){pY317} + ADP (phosphorylation) | Shc-1-p52(h) + PLSCR1(h) <==> Shc-1-p52(h):PLSCR1(h) (binding) | ErbB1(h) + Shc-1-p52(h) <==> ErbB1(h):Shc-1-p52(h) (binding) | shcbp1(m) + Shc-1-p52(h) <==> shcbp1(m):Shc-1-p52(h) (binding) | Shc-1-p52(h) + IL-5Rbeta-isoform1(h){pY593} <==> Shc-1-p52(h):IL-5Rbeta-isoform1(h){pY593} (binding) | Shc-1-p52(h){p} --TC-PTPa(h)--> Shc-1-p52(h) + p (dephosphorylation) | SHC1(h) --> Shc-1-p52(h) (expression). | Grb-2(h) + Shc-1-p46(h) <==> Grb-2(h):Shc-1-p46(h) (binding) | huntingtin(h) + Shc-1-p46(h) <==> huntingtin(h):Shc-1-p46(h) (binding) | Shc-1-p46(h) + APP(m.s.){pY} <==> Shc-1-p46(h):APP(m.s.){pY} (binding) | Shc-1-p46(h) + ATP --> Shc-1-p46(h){pY} + ADP (phosphorylation) | Shc-1-p46(h) + ErbB2(h){pY} <==> Shc-1-p46(h):ErbB2(h){pY} (binding) | ER-alpha(h) + Shc-1-p46(h) <==> ER-alpha(h):Shc-1-p46(h) (binding) | Shc-1-p46(h) + ErbB4(h){pY} <==> Shc-1-p46(h):ErbB4(h){pY} (binding) | Shc-1-p46(h) + PLSCR1(h) <==> Shc-1-p46(h):PLSCR1(h) (binding) | ErbB1(h) + Shc-1-p46(h) <==> ErbB1(h):Shc-1-p46(h) (binding) | SHC1(h) --> Shc-1-p46(h) (expression). | Grb-2(h) + Shc-1-p66(h) <==> Grb-2(h):Shc-1-p66(h) (binding) | Shc-1-p66(h) + ATP --JNK1alpha1(h){p}--> Shc-1-p66(h){pS} + ADP (phosphorylation) | Shc-1-p66(h) + ATP --JNK2alpha-2(h)--> Shc-1-p66(h){pS} + ADP (phosphorylation) | Shc-1-p66(h) + APP(m.s.){pY} <==> Shc-1-p66(h):APP(m.s.){pY} (binding) | Shc-1-p66(h) + ATP --> Shc-1-p66(h){pY} + ADP (phosphorylation) | PLSCR1(h) + Shc-1-p66(h) <==> PLSCR1(h):Shc-1-p66(h) (binding) | ErbB1(h) + Shc-1-p66(h) <==> ErbB1(h):Shc-1-p66(h) (binding) | Grb-2(pg) + Shc-1-p66(h) <==> Grb-2(pg):Shc-1-p66(h) (binding) | Shc-1-p66(h) + SHPS1(pg) <==> Shc-1-p66(h):SHPS1(pg) (binding) | Src(pg) + Shc-1-p66(h) <==> Src(pg):Shc-1-p66(h) (binding) | SHC1(h) --> Shc-1-p66(h) (expression). | c-Kit(h){pY} + Shc-1(h) <==> c-Kit(h){pY}:Shc-1(h) (binding) | Shc-1(h) + SHIP-130(m) <==> Shc-1(h):SHIP-130(m) (binding) | Shc-1(h) + SHIP-145(m) <==> Shc-1(h):SHIP-145(m) (binding) | Shc-1(h) + SHIP2-isoform1(h){pY} <==> Shc-1(h):SHIP2-isoform1(h){pY} (binding) | InsR(h){p} + Shc-1(h) <==> InsR(h){p}:Shc-1(h) (binding) | ErbB2(r){pY1227} + Shc-1(h) <==> ErbB2(r){pY1227}:Shc-1(h) (binding) | ErbB2(r){pY1253} + Shc-1(h) <==> ErbB2(r){pY1253}:Shc-1(h) (binding) | Shc-1(h) + Memo(h) <==> Shc-1(h):Memo(h) (binding) | Shc-1(h) + PI3K-C2beta(h) <==> Shc-1(h):PI3K-C2beta(h) (binding) | Jak2(m) + Shc-1(h) <==> Jak2(m):Shc-1(h) (binding) | GHR(m) + Shc-1(h) <==> GHR(m):Shc-1(h) (binding) | Shc-1(h) + ATP --> Shc-1(h){pY} + ADP (phosphorylation) | Ddr2(m.s.){pY} + Shc-1(h) <==> Ddr2(m.s.){pY}:Shc-1(h) (binding) | Shc-1(h) + PTP-PEST(m.s.) <==> Shc-1(h):PTP-PEST(m.s.) (binding) | PTP-PEST(h) + Shc-1(h) <==> PTP-PEST(h):Shc-1(h) (binding) | Shc-1(h) + IGF-1R(h) <==> Shc-1(h):IGF-1R(h) (binding) | Shc-1(h) + Grb-2(h) <==> Shc-1(h):Grb-2(h) (binding) | Shc-1(h) --> ERK1(h){p} (increase of phosphorylation) | Shc-1(h) --> ERK2(h){p} (increase of phosphorylation) | RhoGDI-2(h) + Shc-1(h) <==> Shc-1(h):RhoGDI-2(h) (binding) | Shc-1(h) + Sos(h) <==> Shc-1(h):Sos(h) (binding) | Grb-2(h) + SHIP(h) + Sos(h) + Shc-1(h) <==> Grb-2(h):SHIP(h):Sos(h):Shc-1(h) (binding) | Shc-1(h) + ErbB2(h) <==> Shc-1(h):ErbB2(h) (binding) | Shc-1(h) + ErbB3(h) <==> Shc-1(h):ErbB3(h) (binding) | ErbB1(h){pY1172}{pY1197} + Shc-1(h) <==> ErbB1(h){pY1172}{pY1197}:Shc-1(h) (binding) | ErbB1-p170(h){pY998}{pY1016}{pY1110}{pY1138}{pY1172}{pY1197} + Shc-1(h) <==> Shc-1(h):ErbB1-p170(h){pY998}{pY1016}{pY1110}{pY1138}{pY1172}{pY1197} (binding) | ErbB2(h){pY1196}{pY1221}{pY1222}{pY1248} + Shc-1(h) <==> ErbB2(h){pY1196}{pY1221}{pY1222}{pY1248}:Shc-1(h) (binding) | ErbB3-isoform1(h){pY1276}{pY1289} + Shc-1(h) <==> ErbB3-isoform1(h){pY1276}{pY1289}:Shc-1(h) (binding) | ErbB4(h){pY1188}{pY1284} + Shc-1(h) <==> ErbB4(h){pY1188}{pY1284}:Shc-1(h) (binding) | Shc-1(h) + trkA(m.s.) <==> Shc-1(h):trkA(m.s.) (binding) | ErbB1(h){pY} + Shc-1(h) <==> Shc-1(h):ErbB1(h){pY} (binding) | Shc-1(h) + NDP52(h) <==> Shc-1(h):NDP52(h) (binding) | shcbp1(m) + Shc-1(h) <==> shcbp1(m):Shc-1(h) (binding) | shcbp1(m) + Shc-1(h) <==> shcbp1(m):Shc-1(h) (binding) | alk(h) + Shc-1(h) <==> alk(h):Shc-1(h) (binding) | SHC1(h) --> Shc-1(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 36 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 139 | Phosphoserine. | Swiss-Prot 53.0 | 349 | Phosphotyrosine. | Swiss-Prot 53.0 | 350 | Phosphotyrosine. | Swiss-Prot 53.0 | 427 | Phosphotyrosine. | Swiss-Prot 53.0 | 350 | Phosphotyrosine (Syk;ZAP70;Sr) | 11075717;9121430;9710204;15592455;9927207 | Phospho.ELM 6.0 | 427 | Phosphotyrosine (Fyn;Lck;InsR) | 11075717;9710204;8610109;9741627;12522270;15592455 | Phospho.ELM 6.0 | 349 | Phosphotyrosine (Syk;ZAP70;Sr) | 11075717;9121430;9710204;10891441;11687594;1559245 | Phospho.ELM 6.0 | 36 | Phosphoserine | 15837797 | Phospho.ELM 6.0 | 54 | Phosphoserine | 16251354 | Phospho.ELM 6.0 | 386 | Phosphothreonine | 16251354 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 153209126 - 153211126 | Agilent_014791 |
chr1 |
Promoter: 153212964 - 153214964 | GSE27584 |
chr1 |
Promoter: 153209126 - 153211126 | GSE27584 |
chr1 |
Promoter: 153212964 - 153214964 | E-GEOD-20553 |
chr1 |
Promoter: 153209126 - 153211126 | E-GEOD-20553 |