Entrez Gene

Basic Information
Gene ID	6464
Name	SHC1
Synonymous	SHC (Src homology 2 domain containing) transforming protein 1;SHC1;SHC (Src homology 2 domain containing) transforming protein 1
Definition	SH2 domain protein C1\|SHC (Src homology 2 domain-containing) transforming protein 1\|SHC-transforming protein 1\|SHC-transforming protein 3\|SHC-transforming protein A
Position	1q21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1379C>T; p.A460V; 1:154963849-154963849	pancreas	carcinoma	Substitution - Missense
c.1379C>T; p.A460V; 1:154963849-154963849	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.982C>T; p.R328W; 1:154966021-154966021	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.982C>T; p.R328W; 1:154966021-154966021	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1204C>A; p.R402R; 1:154965635-154965635	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1066G>A; p.E356K; 1:154965773-154965773	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.873G>A; p.G291G; 1:154966211-154966211	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1261C>T; p.P421S; 1:154965578-154965578	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.78C>G; p.R26R; 1:154970119-154970119	skin	malignant_melanoma	Substitution - coding silent
c.787G>A; p.A263T; 1:154966384-154966384	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.605T>C; p.F202S; 1:154967719-154967719	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.63C>T; p.G21G; 1:154970134-154970134	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1291G>C; p.G431R; 1:154965548-154965548	liver	carcinoma	Substitution - Missense
c.1291G>C; p.G431R; 1:154965548-154965548	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.381C>A; p.S127S; 1:154968534-154968534	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1293T>G; p.G431G; 1:154965546-154965546	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.406G>A; p.A136T; 1:154968509-154968509	thyroid	carcinoma	Substitution - Missense
c.1422G>A; p.L474L; 1:154963806-154963806	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1415G>A; p.R472Q; 1:154963813-154963813	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.420G>T; p.Q140H; 1:154968495-154968495	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.670G>T; p.G224C; 1:154966501-154966501	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.670G>T; p.G224C; 1:154966501-154966501	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.869T>C; p.V290A; 1:154966215-154966215	skin	malignant_melanoma	Substitution - Missense
c.999T>G; p.G333G; 1:154966004-154966004	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1039C>T; p.R347W; 1:154965964-154965964	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1039C>T; p.R347W; 1:154965964-154965964	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.951C>A; p.S317S; 1:154966052-154966052	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.800C>T; p.A267V; 1:154966371-154966371	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.983G>A; p.R328Q; 1:154966020-154966020	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.376G>A; p.V126I; 1:154968539-154968539	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.829C>T; p.P277S; 1:154966342-154966342	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.25G>A; p.G9R; 1:154970172-154970172	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.649G>C; p.D217H; 1:154967675-154967675	prostate	adenoma	Substitution - Missense
c.187C>A; p.L63I; 1:154969427-154969427	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.699G>T; p.E233D; 1:154966472-154966472	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.286A>C; p.T96P; 1:154968785-154968785	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.196delA; p.M66fs*50; 1:154969418-154969418	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.898A>G; p.M300V; 1:154966186-154966186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1200G>A; p.L400L; 1:154965639-154965639	breast	carcinoma	Substitution - coding silent
c.1387G>A; p.E463K; 1:154963841-154963841	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.850T>C; p.L284L; 1:154966321-154966321	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.785_786CC>TT; p.A262V; 1:154966385-154966386	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.729C>A; p.F243L; 1:154966442-154966442	skin	malignant_melanoma	Substitution - Missense
c.889C>T; p.R297C; 1:154966195-154966195	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.106C>T; p.R36W; 1:154970091-154970091	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.919C>G; p.P307A; 1:154966165-154966165	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.950C>G; p.S317C; 1:154966053-154966053	breast	carcinoma	Substitution - Missense
c.721A>T; p.N241Y; 1:154966450-154966450	liver	carcinoma	Substitution - Missense
c.721A>T; p.N241Y; 1:154966450-154966450	liver	carcinoma	Substitution - Missense
c.200G>A; p.R67H; 1:154969414-154969414	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1080C>G; p.R360R; 1:154965759-154965759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.677C>T; p.A226V; 1:154966494-154966494	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.100C>T; p.P34S; 1:154970097-154970097	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.639C>T; p.V213V; 1:154967685-154967685	prostate	carcinoma	Substitution - coding silent
c.538C>G; p.L180V; 1:154967786-154967786	ovary	other; neoplasm	Substitution - Missense
c.1093C>T; p.P365S; 1:154965746-154965746	skin	malignant_melanoma	Substitution - Missense
c.1093C>T; p.P365S; 1:154965746-154965746	skin	malignant_melanoma	Substitution - Missense
c.1155C>G; p.S385R; 1:154965684-154965684	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1366C>T; p.P456S; 1:154963862-154963862	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.637G>C; p.V213L; 1:154967687-154967687	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.73A>C; p.T25P; 1:154970124-154970124	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.73A>C; p.T25P; 1:154970124-154970124	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.73A>C; p.T25P; 1:154970124-154970124	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.73A>C; p.T25P; 1:154970124-154970124	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.73A>C; p.T25P; 1:154970124-154970124	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.755G>T; p.G252V; 1:154966416-154966416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.284C>T; p.A95V; 1:154968787-154968787	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.364A>G; p.I122V; 1:154968551-154968551	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.393C>T; p.L131L; 1:154968522-154968522	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.594C>T; p.F198F; 1:154967730-154967730	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.594C>T; p.F198F; 1:154967730-154967730	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.890G>A; p.R297H; 1:154966194-154966194	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.700C>T; p.P234S; 1:154966471-154966471	skin	malignant_melanoma	Substitution - Missense
c.375C>A; p.T125T; 1:154968540-154968540	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.122C>T; p.P41L; 1:154970075-154970075	skin	malignant_melanoma	Substitution - Missense
c.757_758insG; p.V253fs*62; 1:154966413-154966414	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.757delG; p.V253fs*2; 1:154966414-154966414	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1101G>C; p.S367S; 1:154965738-154965738	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.757delG; p.V253fs*2; 1:154966414-154966414	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.757delG; p.V253fs*2; 1:154966414-154966414	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.757_758insG; p.V253fs*62; 1:154966413-154966414	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.757_758insG; p.V253fs*62; 1:154966413-154966414	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.757delG; p.V253fs*2; 1:154966414-154966414	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.285G>T; p.A95A; 1:154968786-154968786	skin	malignant_melanoma	Substitution - coding silent
c.1089A>C; p.P363P; 1:154965750-154965750	pancreas	carcinoma	Substitution - coding silent
c.1315C>T; p.R439C; 1:154963913-154963913	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1078C>T; p.R360C; 1:154965761-154965761	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]