Entrez Gene

Basic Information
Gene ID	596
Name	BCL2
Synonymous	B-cell CLL/lymphoma 2;BCL2;B-cell CLL/lymphoma 2
Definition	apoptosis regulator Bcl-2\|protein phosphatase 1, regulatory subunit 50
Position	18q21.3
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
2 Bcl-2(h) <==> Bcl-2(h):Bcl-2(h) (binding)
Bcl-2(h) + Bax(h) <==> Bcl-2(h):Bax(h) (binding)
Bcl-2(h) + Bax(m) <==> Bcl-2(h):Bax(m) (binding)
BimS(m) + Bcl-2(h) <==> BimS(m):Bcl-2(h) (binding)
BimL(m) + Bcl-2(h) <==> BimL(m):Bcl-2(h) (binding)
BimEL(m) + Bcl-2(h) <==> BimEL(m):Bcl-2(h) (binding)
Hrk(h) + Bcl-2(h) <==> Hrk(h):Bcl-2(h) (binding)
DEBCL(d) + Bcl-2(h) <==> DEBCL(d):Bcl-2(h) (binding)
Bcl-2(h) + BimL(m) + LC8(m) <==> Bcl-2(h):BimL(m):LC8(m) (binding)
BAR(h) + Bcl-2(h) <==> BAR(h):Bcl-2(h) (binding)
Bcl-B(h) + Bcl-2(h) <==> Bcl-B(h):Bcl-2(h) (binding)
Bik(m) + Bcl-2(h) <==> Bik(m):Bcl-2(h) (binding)
bag1(m) + Bcl-2(h) <==> bag1(m):Bcl-2(h) (binding)
bag1(m) + Bcl-2(h) + Raf-1(h) <==> bag1(m):Bcl-2(h):Raf-1(h) (binding)
Bcl-2(h) + PS1(h) <==> Bcl-2(h):PS1(h) (binding)
bad(h) + Bcl-2(h) <==> bad(h):Bcl-2(h) (binding)
Bcl-2(h) + Bid(m) <==> Bcl-2(h):Bid(m) (binding)
BimEL(h) + Bcl-2(h) <==> BimEL(h):Bcl-2(h) (binding)
BimS(h) + Bcl-2(h) <==> BimS(h):Bcl-2(h) (binding)
BimAD(h) + Bcl-2(h) <==> BimAD(h):Bcl-2(h) (binding)
Bcl-2(h) --Caspase-3(h)--> protein remnants (processing)
Bcl-2(h) + Bik(h) <==> Bcl-2(h):Bik(h) (binding)
Bcl-2(h) + PUMA(h) <==> Bcl-2(h):PUMA(h) (binding)
BimEL-p22(m) + Bcl-2(h) <==> BimEL-p22(m):Bcl-2(h) (binding)
Bcl-2(h) + ASPP2(h) <==> Bcl-2(h):ASPP2(h) (binding)
p53(h) + Bcl-2(h) <==> p53(h):Bcl-2(h) (binding)
Bcl-2(h) + SMN(h) <==> Bcl-2(h):SMN(h) (binding)
Beclin-1(h) + Bcl-2(h) <==> Beclin-1(h):Bcl-2(h) (binding)
Bcl-2(h) + ATP --> Bcl-2(h){pS} + ADP (phosphorylation)
Bcl-2(h) + ATP --PKCalpha(h)--> Bcl-2(h){pS70} + ADP (phosphorylation)
Bcl-2(h) + ATP --ERK1(h)--> Bcl-2(h){pS70} + ADP (phosphorylation)
Bcl-2(h) + ATP --ERK2(h)--> Bcl-2(h){pS70} + ADP (phosphorylation)
Raf-1(h) + Bcl-2(h) <==> Raf-1(h):Bcl-2(h) (binding)
Bcl-2(h) + bad(m.s.) <==> Bcl-2(h):bad(m.s.) (binding)
Bcl-2(h) + ATP --> Bcl-2(h){p} + ADP (phosphorylation)
Bcl-2(h) --Caspase(h)--> Bcl-2-p23(h) + protein remnants (cleavage)
Bcl-2(h) --Caspase(h)--> protein remnants (cleavage)
Bcl-2(h) --Caspase(ha)--> protein remnants (cleavage)
Bcl-2(h) --Caspase-3(ha)--> protein remnants (cleavage)
Bcl-2(h) --Caspase-8(ha)--> protein remnants (cleavage)
PS2(m.s.) + Bcl-2(h) <==> PS2(m.s.):Bcl-2(h) (binding)
Bcl-2(h) --Caspase-8(h)--> protein remnants (cleavage)
Bcl-2(h) + NAC(h) <==> Bcl-2(h):NAC(h) (binding)
tBid(h) + Bcl-2(h) <==> tBid(h):Bcl-2(h) (binding)
Bcl-2(h) --> ICAD(h) (decrease of cleavage)
Cu-ZnSOD(h) + Bcl-2(h) <==> Cu-ZnSOD(h):Bcl-2(h) (binding)
Cu-ZnSOD(h) + Bcl-2(h) <==> Cu-ZnSOD(h):Bcl-2(h) (binding)
Bcl-2(h) + Beclin-1(h) <==> Bcl-2(h):Beclin-1(h) (binding)
Bcl-2(h) --> bad(m){pS136}{pS155} (decrease of phosphorylation)
Bcl-2(h) + bad(m) <==> Bcl-2(h):bad(m) (binding)
BCL2(h) --> Bcl-2(h) (expression).
Bcl-2(h){pS70} --> Bcl-2(h) + p (dephosphorylation)
BDNF(m.s.) --> Bcl-2(h) (increase of abundance)
Cdk5(h) --> Bcl-2(h) (increase of abundance)
AKT-2(m.s.) --> Bcl-2(h) (increase of abundance)
EGF(m.s.) --/ Bcl-2(h) (decrease of abundance)
s100a11(h) --> Bcl-2(h) (increase of abundance)
slc5a3(h) --/ Bcl-2(h) (decrease of abundance)
CHIP(h) --/ Bcl-2(h) (decrease of abundance)
Fam(h) --/ Bcl-2(h) (decrease of abundance)
TIP30(m.s.) --/ Bcl-2(h) (decrease of abundance)
IFNalpha2a(h) --> Bcl-2(h) (increase of abundance)
IFNbeta(m.s.) --> Bcl-2(h) (increase of abundance)
IFNgamma(h) --> Bcl-2(h) (increase of abundance)
opiomelanocortin(m.s.) --> Bcl-2(h) (increase of abundance)
UV --/ Bcl-2(h) (decrease of abundance)
ET-1(m.s.) --> Bcl-2(h) (increase of abundance)
Bcl-2-alpha(h) + IP3R1(m) <==> Bcl-2-alpha(h):IP3R1(m) (binding)
Bcl-2-alpha(h) + IP3R2(m) <==> Bcl-2-alpha(h):IP3R2(m) (binding)
Bcl-2-alpha(h) + IP3R3(m) <==> Bcl-2-alpha(h):IP3R3(m) (binding)
Bcl-2-alpha(h) + IP3R(m) <==> Bcl-2-alpha(h):IP3R(m) (binding)
Bcl-2-alpha(h) + Beclin-1(m) <==> Bcl-2-alpha(h):Beclin-1(m) (binding)
BCL2(h) --> Bcl-2-alpha(h) (expression).
BCL2(h) --> Bcl-2-beta(h) (expression).
BCL2(h) --> BCL2(h) (expression).
hsa-miR-15a --/ BCL2(h) (predicted)
hsa-miR-16 --/ BCL2(h) (predicted)
hsa-miR-15b --/ BCL2(h) (translational repression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
70	Phosphoserine (by PKC) (By similarity).		Swiss-Prot 53.0
74	Phosphothreonine	12039864	Phospho.ELM 6.0
56	Phosphothreonine	12039864	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr18	Promoter: 59137093 - 59139093	Agilent_014791
chr18	Promoter: 59137093 - 59139093	GSE27584
chr18	Promoter: 59137093 - 59139093	GSE27584
chr18	Promoter: 59137093 - 59139093	PMID:16242928
chr18	Promoter: 59137093 - 59139093	PMID:16242928
chr18	Promoter: 59137093 - 59139093	PMID:15569975
chr18	Promoter: 59137093 - 59139093	PMID:15569975
chr18	Promoter: 59137093 - 59139093	PMID:11724359
chr18	Promoter: 59137093 - 59139093	PMID:11724359
chr18	Promoter: 59137093 - 59139093	PMID:15172987
chr18	Promoter: 59137093 - 59139093	PMID:15172987
chr18	Promoter: 59137093 - 59139093	PMID:17139617
chr18	Promoter: 59137093 - 59139093	PMID:17139617

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]